V
Valdoxan
Guest
Have done some quick research into this relatively new melatonergic AD, and my pharma knowledge is not what it should be unfortunately. A search of BL has produced a couple of threads, but not enough for me to be able to happily and confidently UNTZ on recreational drugs (in moderation of course) whilst taking this for delayed sleep phase syndrome. I figured that as more people are going to be prescribed this in the coming weeks, months etc. that a thread covering the basics would be a good idea.
"Agomelatine is a melatonergic agonist (MT1 (Ki=0.10nM±0.01nM) and MT2 receptors (Ki=0.12nM±0.02nM)) and 5-HT2C antagonist (IC50=270nM; pKi=6.15±0.04). Binding studies indicate that it has no effect on monoamine uptake and no affinity for adrenergic, histaminergic, cholinergic, dopaminergic and benzodiazepine receptors, nor other serotonergic receptors."
http://en.wikipedia.org/wiki/Agomelatine
So, the basics: MDMA, cocaine, psychs, stims etc. etc.
What is safe to indulge in, what is not, and to what degree is this known?
"Agomelatine is a melatonergic agonist (MT1 (Ki=0.10nM±0.01nM) and MT2 receptors (Ki=0.12nM±0.02nM)) and 5-HT2C antagonist (IC50=270nM; pKi=6.15±0.04). Binding studies indicate that it has no effect on monoamine uptake and no affinity for adrenergic, histaminergic, cholinergic, dopaminergic and benzodiazepine receptors, nor other serotonergic receptors."
http://en.wikipedia.org/wiki/Agomelatine
So, the basics: MDMA, cocaine, psychs, stims etc. etc.
What is safe to indulge in, what is not, and to what degree is this known?