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Tramadol and MDMA, lost magic?

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D0CT0R

Greenlighter
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Mar 30, 2016
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Do you know does tramadol do same type of "damage to brain" that MDMA does. And I mean that you loose the magic from MDMA, can you loose the MDMA magic with tramadol? 8(
 
D0CT0R said:
Do you know does tramadol do same type of "damage to brain" that MDMA does. And I mean that you loose the magic from MDMA, can you loose the MDMA magic with tramadol? 8(
Click to expand...


Tramadol while being used for pain, is also surprisingly a serotonin reuptake inhibitor.

That method of action is believed to be why many persons on SSRI medications have a much lessened or even almost no effects from MDMA.

You likely need a long term (several weeks) washout period without using tramadol to properly experience MDMA, if the re-uptake inhibition is causing the issue.


Because tramadol is a re-uptake inhibitor -- it should never be taken WITH a serotonin releasing drug (like MDMA) -- it runs the risk of serotonin syndrome (which has occurred with tramadol use)
 
Tramadol has many ways of acting. At first it is a serotonin-RELEASER, a norepinephrine-reuptake-inhibitor, an (weak) opioid and a NMDA-Antagonist. But in my experience the magic feeling of tramadol gets less after a longer period of everyday use, but not in the way that you don't feel any effects, it's just not as energizing anymore. And after a break it hits you nearly like in the first time.
 
Amml said:
Tramadol has many ways of acting. At first it is a serotonin-RELEASER, a norepinephrine-reuptake-inhibitor, an (weak) opioid and a NMDA-Antagonist. But in my experience the magic feeling of tramadol gets less after a longer period of everyday use, but not in the way that you don't feel any effects, it's just not as energizing anymore. And after a break it hits you nearly like in the first time.
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No , it is a reuptake inhibitor of serotonin.


  • Tramadol is a mu-opioid receptor agonist as well as an inhibitor of the reuptake of norepinephrine and serotonin in the central nervous system (CNS).


http://www.ebmconsult.com/articles/tramadol-interaction-ssri-serotonin-syndrome-mechanism

In terms of specific neurotransmitter effects, at the central level, tramadol is a mu-opioid receptor agonist. The affinity of tramadol for mu-opioid receptors (analgesic effect) is 10-fold less than codeine. However, the active metabolite of tramadol, o-desmethyltramadol, has a far greater affinity (up to 200-fold) than the parent compound. In addition to its central effects on mu receptors, at the peripheral level, tramadol inhibits serotonin and norepinephrine reuptake.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/


It is NOT a RELEASER
 
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