Anandamide (with its relatives) and many synthetic cannabinoids (say, indazole-3-carboxamides), some FAAH inhibitors, some mu-opioid agonists (fentanyls, moramide, phenampromide), many nootropics, all peptides (e.g. endorphins) and a great number of GABAA receptor positive allosteric modulators (benzodiazepines, Z-drugs, barbiturates, glutethimide etc.).Yea I suppose beyond lysergamides, what other well known psychoactive amides are there? If any..
-GC
Does anyone actually know when exactly the term "acid" was first used for LSD?
Nikethamide, racetam class drugs, zolpidem, methaqualone, bucinnazine, efavirenz, adrafinil, brorphine, orphine, chlorphine, gaboxadol, dare I mention caffeine?Yea I suppose beyond lysergamides, what other well known psychoactive amides are there? If any..
-GC
Can't say for certain. It's a dumb term though, LSD isn't even an acid, it's a base.Does anyone actually know when exactly the term "acid" was first used for LSD?
the indole amine isn't basic, the its the tertiary amine. tertiary amines are more nucleophilic than secondary or primary amines.Amides are generally weakly acidic... but tertiary amides are almost neutral. It's not important, because clearly LSD HAS an amine but once again it's tertiary. But the indole has a secondary amine (they are usually the most basic. I think the pKa for LSD is 7.8 so ALMOST neutral.
'Hey man, y'got any neutral.'
this guy drugsNikethamide, racetam class drugs, zolpidem, methaqualone, bucinnazine, efavirenz, adrafinil, brorphine, orphine, chlorphine, gaboxadol, dare I mention caffeine?
The conjugated spine, right up to the carboxamide group, from the indole nucleus, keep the molecule planar, which is the gold standard for 5HT2a receptor agonists (why bromodragonfly is so silly potent). The amide group has some effects, hence why LSZ is so similar - all to do with the amide adopting the lowest energy, gull wing shape.There are many 5HT2a ligands that are amines, DMT being the most famous. DMT is simply a fragment of the LSD scaffold. I presume the rest of the scaffold is there to keep the inolethylamine in the receptor..... oh, and to improve pharmakinetics and LogP.
F&B would know more - he's studied it for decades from what I know.
It's because saure is German for acid (hence words like sour) and Albert Hoffman was Swiss with German as his mother tongue (and it's the diethylamide of lysergic acid)Can't say for certain. It's a dumb term though, LSD isn't even an acid, it's a base.