^That's hard to say. I would really say that you would have to take Etizolam or any short-acting Benzodiazepine at least once per day to actually produce some tolerance. If you were taking a longer-acting Benzodiazepine like Chlordiazepoxide (Librium), Diazepam (Valium) or even Clonazepam (Klonopin), this might be different, as there will be carry over from the previous day due to the long half-lives of these drugs.
I'm not a doctor. Just an addict with a lot of experience in the field, so take my advice with a grain of salt. I feel the ideal situation, if you choose to use Benzodiazepines, would be to limit your use to at most, every other day. If you find that this is not possible, make it once per day, at the time when you need it the most. If you begin taking Etizolam more frequently than once per day, you are running the risk of developing tolerance and dependence.
Don't escalate your dosage, ever. Get by with as little as possible. If you follow these rules, you can avoid addiction, tolerance and depedence and you can retain the effectiveness of the Etizolam at the same time. It's a win-win. If you get to a point where your initial dosage is no longer effective, this is an indication of tolerance. It is important that you approach this in a smart way. If you escalate the dosage, you are starting down a dangerous path. What you should do, is take a short break from the medication to, at least partially, reset your tolerance.