Stimulants The Science of Meth Neurotoxicity and Strategies for Prevention and Treatment (2021 version)

[Jabberwocky]

I don’t recall seeing this article posted previously.

The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment

Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the accurate mechanism of toxic effect of the drug on central nervous system (CNS) has not yet been completely deciphered...

www.frontiersin.org

It seems an excellent summary and provides evidence for various personl remedies recommended in other good threads on this topic like this one from 2 years ago:

Stimulants - Meth neurotoxicity and my loud pill box of meds and remedies!

Methamphetamine is a serious neurotoxic substance so is not silly to tackle this problem to reduce harmful tragedies at the end of the road! So I have two boxes fill with great psychotropic that I love or just need. The first one is an small wooden box that I have all my stimulant, psychedelic...

www.bluelight.org

 

[Skorpio]

A bit of a dig, but I would be remiss to not link the 3 classic Epsilon Alpha threads going into amphetamine tolerance and neurotoxicity mitigation.

Amphetamine Neurotoxicity and Tolerance Reduction/Prevention

Hello, I'm Delta Gamma from Imminst, a while back I made a thread about preventing some of the negative consequences of amphetamine use particularly at AD(H)D dosage patterns which can be found via the link below. I believe that this information may be more appreciated by this audience. NOTE: I...

www.bluelight.org

Amphetamine Neurotoxicity and Tolerance Reduction/Prevention II

Link to previous thread: http://www.bluelight.ru/vb/threads/577851-Amphetamine-Neurotoxicity-and-Tolerance-Reduction-Prevention The Basic Stack. - ~250mg elemental magnesium at bed. Why: magnesium deficiency is extremely common and known to worsen neurotoxic measures in mouse models. May also...

www.bluelight.org

Amphetamine Neurotoxicity and Tolerance Reduction/Prevention III

Links to previous versions: Amphetamine Neurotoxicity and Tolerance Reduction/Prevention Amphetamine Neurotoxicity and Tolerance Reduction/Prevention II Amphetamine Induced Changes in Protein Degradation and Apoptosis: PKCδ as a Central Regulator Introduction: Amphetamine (AMP) and...

www.bluelight.org

These threads really cover some theoretical ground but have really valuable discussion of a lot of papers included.

 

[Jabberwocky]

A bit of a dig, but I would be remiss to not link the 3 classic Epsilon Alpha threads going into amphetamine tolerance and neurotoxicity mitigation.

I don’t mind the dig and I’m really glad you posted the links to those threads. I’ve actually searched a few times for what we have on stimulant neurotoxicity, including today before I posted the paper above, and those 3 Epsilon Alpha threads never appeared in the results that I can recall.

At any rate though, i don’t think there is any harm in having this thread in Other Drugs while the earlier ones are in in NPD. I don’t know to what extent these sub-forums get the same readers but OD still does get a lot of basic questions about meth damage and mitigation.

Thanks for the leads.