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Ketamine salts solubility

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I'm not quite sure hw to put this, but show me these compounds in PubChem.

Aminorex and ring-substituted aminorex derivatives exist as zwitterions. That's why the subjective effects of 3,4-methylendioxiy aminorex is MORE active than MDA or MDMA and it longer acting and metabolism is predicable.

Example 13 of the original George Ireland Poos 1963 patent descries it in detail.

If I may suggest, I think people would appreciate someone detailing why the ring-substituted 4MAR derivatives are a LOT more toxic han the simple PEAs.

Even before we made example 13, I E-mailed David Nichols and his response was BRIEF. He said 'don't make the alpha methyl derivatives, they are really toxic.

Why? Because guanidine derivatives cause severe hypertension.

Fast and Bulbous suggested a homologue, we made it, it's like MDMA on steroids.


ibb.co

z hosted at ImgBB

Image z hosted in ImgBB
ibb.co ibb.co


We studied the QSAR of the aminorex series and found:

-5HT2a affinity is not a parctical target i.e. one cannot produce 2,5-dimthoxy-4-<(pseudo)halogen> for psychedelic activity.
-4-methyl-aminorex derivatives have significant 5HT2b activity. Dr. David Nichols specifically suggested NOT tp test it or ring-substituted examples.

p-(pseudo)halogen examples ARE more potent BUT duration of action is VERY long.

Replacing the aromatic with a benzofuran or a benzothiophene are as active as the ring-substituted benzene examples. Be clear, Nichols knows the law which is why an O or an S it part of the aromatic system - they are NOT substituted enzene rings containing O or Substituents.

BTW read PiHKAL. Shlgins recognized the key moities of ring-substitution.
 
1-(2-bromo-4,5-methylenedioxyphenyl)-2-amino-1-carbomethoxypropane.png


MIKE
1-(2-bromo-4,5-methylenedioxyphenyl)-2-amino-1-carbomethoxypropane

1-(2-bromo-4,5-methylenedioxyphenyl)-2-methylamino-1-carbomethoxypropane.png


MARCUS
1-(2-bromo-4,5-methylenedioxyphenyl)-2-methylamino-1-carbomethoxypropane

1-(2-bromo-4,5-methylenedioxyphenyl)-2-ethylamino-1-carbomethoxypropane.png


QUETTA
1-(2-bromo-4,5-methylenedioxyphenyl)-2-ethylamino-1-carbomethoxypropane

1-(2-bromo-4,5-methylenedioxyphenyl)-2-propylamino-1-carbomethoxypropane.png


STEPHANIE
1-(2-bromo-4,5-methylenedioxyphenyl)-2-propylamino-1-carbomethoxypropane

1-(2-bromo-4,5-methylenedioxyphenyl)-2-allylamino-1-carbomethoxypropane.png


ANDROO
1-(2-bromo-4,5-methylenedioxyphenyl)-2-allylamino-1-carbomethoxypropane

1-(naphth-2-yl)-1-carbomethoxy-2-aminopropane.png


ANDERSON_VANDERBILT_COOPER
1-(naphth-2-yl)-1-carbomethoxy-2-aminopropane

In Case The 1st Five Don't Work.
 
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1-(3,4-dimethylphenyl)-1-carbomethoxy-2-methylaminopropane.png


TONY_THE_TIGER
1-(3,4-dimethylphenyl)-1-carbomethoxy-2-methylaminopropane

1-(3,4-dimethylphenyl)-1-carboethoxy-2-methylaminopropane.png


ZOOSIE_SUSIE
1-(3,4-dimethylphenyl)-1-carboethoxy-2-methylaminopropane

1-(3,4-dimethylphenyl)-1-carboethoxy-2-ethylaminopropane.png


ERIN_AARON
1-(3,4-dimethylphenyl)-1-carboethoxy-2-ethylaminopropane

1-(3-methyl-4-(1-oxoethyl)-phenyl)-1-carbomethoxy-1-(2-piperidinyl)-methane.png


HONEYSUCKLE_COCA_PUFF_DADDY_AMINE
1-(3-methyl-4-(1-oxoethyl)-phenyl)-1-carbomethoxy-1-(2-piperidinyl)-methane
 
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1-(2-methylphenyl)-1-carbomethoxy-2-aminopropane.png


ALLEN
1-(2-methylphenyl)-1-carbomethoxy-2-aminopropane

1-(2-methoxyphenyl)-1-carbomethoxy-2-aminopropane.png


SHANNON
1-(2-methoxyphenyl)-1-carbomethoxy-2-aminopropane

1-(3-methylphenyl)-1-ethylaminocyclohexane.png


THANATOPSIS
1-(3-methylphenyl)-1-ethylaminocyclohexane

1-methylamino-1-(naphthalene-2-yl)-cyclohexane.png


CASIE_M_LAIRD
1-methylamino-1-(naphthalene-2-yl)-cyclohexane

aka "DISCO_DISSO!"

Yeah, Baby!!
 
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(RS)-N,N-Dimethyl-1-%5b(2-methylphenyl)-phenyl-methoxy%5d-propan-2-amine.png


ORPHENADREST
(R,S)-N,N-dimethyl-1-(2-methylphenyl)-phenyl-methoxy-propan-2-amine
 
1-phenyl-1-carbomethoxy-2-aminopropane.png


ADROIT
1-phenyl-1-carbomethoxy-2-aminopropane

1-phenyl-1-hydroxy-2-aminopropane.png


PPA_A_PRECURSOR
1-phenyl-1-hydroxy-2-aminopropane -->

1-phenyl-1-chloro-2-aminopropane.png


INTERMEDIATE 1
1-phenyl-1-chloro-2-aminopropane -->

1-phenyl-1-cyano-2-aminopropane.png


CYANO_INTERMEDIATE_2
1-phenyl-1-cyano-2-aminopropane

1-phenyl-1-carboxyl-2-aminopropane.png


INTERMEDIATE_3_CARBOXYLATE
1-phenyl-1-carboxyl-2-aminopropane
 
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1,2-dihydroxybenzene.png


CATECHOL
1,2-dihydroxybenzene

-->

1,3-benzodioxole.png


1,3-BDO
1,3-benzodioxole

-->

1-(1,3-benzodioxole-5-yl)-1-oxopropane.png


OXOPROPINTERMEDIATE
1-(1,3-benzodioxole-5-yl)-1-oxopropane

-->

1-(1,3-benzodioxole-5-yl)-1-oxo-2-bromopropane.png


BROMOPROPOINTERMEDIATE
1-(1,3-benzodioxole-5-yl)-1-oxo-2-bromopropane

-->

1-(1,3-benzodioxole-5-yl)-1-oxo-2-methylaminopropane.png


METHYLONE
1-(1,3-benzodioxole-5-yl)-1-oxo-2-methylaminopropane

-->

1-(1,3-benzodioxole-5-yl)-1-hydroxy-2-methylaminopropane.png


HYDROXY-X-INTERMEDIATE
1-(1,3-benzodioxole-5-yl)-1-hydroxy-2-methylaminopropane

-->

1-(1,3-benzodioxole-5-yl)-1-chloro-2-methylaminopropane.png


X-CHLOR-INTERMEDIATE
1-(1,3-benzodioxole-5-yl)-1-chloro-2-methylaminopropane

-->

1-(1,3-benzodioxole-5-yl)-1-cyano-2-methylaminopropane.png


X-CYANO-INTERMEDIATE
1-(1,3-benzodioxole-5-yl)-1-cyano-2-methylaminopropane

-->

1-(1,3-benzodioxole-5-yl)-1-carboxyl-2-methylaminopropane.png


CARBO-XYX-INTERMEDIATE
1-(1,3-benzodioxole-5-yl)-1-carboxyl-2-methylaminopropane

-->

1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-2-methylaminopropane.png


CARBOXY-X
1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-2-methylaminopropane
 
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geminal diamines tend to lose ammoinia to form imines.
imines in turn readily hydrolyse to carbonyl compounds.
your compounds are both geminal diamines, so the pharmacology you would expect to see is essentially the pharmacology of benzylmethylketone
 
N-allyl-1-phenyl-1-carbomethoxy-2-aminopropane.png


FRED_EVANS
N-allyl-1-phenyl-1-carbomethoxy-2-aminopropane

N-allyl-1-(4-methoxyphenyl)-1-carbomethoxy-2-aminopropane.png


MICHAEL_BALLARD
N-allyl-1-(4-methoxyphenyl)-1-carbomethoxy-2-aminopropane

N-allyl-1-(3,4-dichlorophenyl)-1-carbomethoxy-2-aminopropane.png


MILO_STAPLETON
N-allyl-1-(3,4-dichlorophenyl)-1-carbomethoxy-2-aminopropane
 
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1-(4-chlorophenyl)-1-(2-pyridinyl)-3-dimethylaminopropane.png


CHLORPHENIRAMINE
1-(4-chlorophenyl)-1-(2-pyridinyl)-3-dimethylaminopropane

antihistamine
 
(6aR,9R)-9-(2-ethyl-2-azabutyl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo-%5b4,3-fg%5d-quinoline.png


DEREK
(6aR,9R)-9-(2-ethyl-2-azabutyl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo-[4,3-fg]-quinoline

LSD-025 + THF + LiAlH4 --> (6aR,9R)-9-(2-ethyl-2-azabutyl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo-[4,3-fg]-quinoline

aka DESOXOLSD-025.
 
Do Not Eat x-CYANO-intermediate. It could be deadly.

1-(3,4-dimethylphenyl)-1-methyl-1-(2-piperidinyl)methane.png


SMOOTH_OPERATOR
1-(3,4-dimethylphenyl)-1-methyl-1-(2-piperidinyl)methane
 
someguyontheinternet said:
You'll want to look up solubilities for any substance you plan on using. I was able to get like 15mg/spray with both MDA and MDMA solutions using 0.9% irrigation saline

In hindsight it was probably a bad idea to use saline, I should have used distilled water. Always boil the water for a few minutes before making your solution, there might be bacteria in the bottles as well. The sprays will probably be good for 15-30 days before you start getting contamination and risking sinus infections
Click to expand...

Well I'm more concerned about the countless different inactive ingredients used as binders and fillers in the tablets I plan to use to make a nasal spray solution out of?
 
If you're crushing the pills then soaking in liquid to dissolve the active just filter and I don't think you'll have any issues. Syringe filters would work well for this purpose
 
4-isobutyl-1-((1-carbomethoxy)ethyl)benzene.png


FRUITY_PEBBLES
4-isobutyl-1-((1-carbomethoxy)ethyl)benzene

Advanced Medicine For Pain.
 
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