Ketamine salts solubility

[Dresden]

LUCKY 7's
-7,7-dimethyl-N,N-diethyllysergamide
-will not aromatize to the pyridinium cation

MOE

N-methyl: JOE
N-ethyl: MOJO

BI-MDA

N-methyl: BI-ECSTASY
N-ethyl: BI-MDE

HI-GUY

FESTIE PRO

WAKE N BAKE

SPARKLY
1-(3,4-methylenedioxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1-(4-chloro-2,5-dimethoxyphenyl)-2-aminopropane

LYFT
1-phenyl-2-phenyloxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizine

UBER
3-carbomethoxy-N-pentyl-7-oxo-1-phenyl-2-(3,4-methylenedioxyphenyl)oxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizine

SWIFTY
1,9-diphenyl-3,7-dioxo-1,2,3,4,5,6,7,8,9-nonahydroquinolizine

SPUNSOME
1,9-diphenyl-2,8-diphenyloxy-3,7-dicarbomethoxy-1,2,3,4,5,6,7,8,9-nonahydroquinolizine

FANTASMAGORIC
1-(1-pentyl-4-methylindol-3-yl)-1-(1-(2-(3,4-methylenedioxyphenyl)-1-methylethyl)-3-carbomethoxypiperidin-4-yl)methanone

2-BENZYL-DMT
1-(2-benzyl-indol-3-yl)-2-dimethylaminoethane

2-PIPERONYL-PSILOCIN

COCA OPIOID AMPHETAMINE
3,4-diphenylcarbonyloxyl-N-(2-phenyl-1-methylethyl)morphinan

iso-2CD-DMT
1-(dimethylamino)-2-(5-methyl-4,7-dimethoxyindol-3-yl)ethane

5,6-MDO-DMT
1-dimethylamino-2-(5,6-methylenedioxyindol-3-yl)ethane

SILLY CYBIN
1-(4-phenylcarbonyloxyindol-3-yl)-2-dimethylaminoethane

DOCTOR SEUSS
2-piperidin-4-yl-2-(3-methoxyphenyl)cyclohexanone

WINNIE THE POOH
1-(3,4-dioxocyclohexyl)-1-oxo-2-methylaminopropane

TIGA
1-carbomethoxy-1-cyclohexyl-2-methylaminopropane

SOMA
1-(3,4-diphenylcarbonyloxyphenyl)-2-aminoethane

GROOVY
4-methylindol-3-yl piperidin-4-yl ether

THE PIED PIPER
4-carbomethoxypiperidin-4-yl phenyl ether

PAPAVERA
1-(2-phenyl-1-methylethyl)piperidin-4-yl-carbomethoxy-(3,4-methylenedioxyphenyl)ammonia

BARRY
1-(piperidin-4-yl)-1-(4-bromo-2,5-dimethoxyphenyl)methane

SWEET WATER
1-(piperidin-4-yl)-1-(3,4-methylenedioxyphenyl)methanone

THE WILD CHILD
1-carbomethoxy-1-(2-methylthiophen-5-yl)-1-(2-piperidinyl)methane

JACK
N-(2-phenyl-1-methylethyl)piperidin-4-yl phenyl ether

JILL
N-(2-(3,4-methylenedioxyphenyl)-1-methylethyl)piperidin-4-yl 3,4-methylenedioxyphenyl ether

JACQUE
N-(2-(3,4-methylenedioxyphenyl)-1-methylethyl)piperidin-4-yl phenyl ether

ANDRES
N-(2-phenyl-2-carbomethoxy-1-methylethyl)-4-carbomethoxypiperidin-4-yl phenyl ether

STU
pyrrolidin-3-yl phenyl ether

HYBRID
N-(2-(indol-3-yl)ethyl)Pyrrolidin-3-yl phenyl ether

SPACE DUST
N-carbomethoxy-3,4-diphenylcarbonyloxyphenyl-(N-(1-(3-methoxyphenyl)cyclohex-2-oneyl)piperidin-4-yl)amine

BUZZ ALDRICH
1-((3-methoxyphenyl)-cyclohex-2-oneyl)-4-(carbomethoxy)piperidine-4-yl 3,4-diphenylcarbonyloxyphenyl ether

CHEWBAKA
4-methoxy-2-oxaindan-6-yl piperidine-4-yl ether

MARQUIS
1-(3-carbomethoxyphenyl)-2-ethylaminopropane

NINXSXES
N-methyl-1,2,3,4,11,12-hexahydromorphinan

-bare bones opioid
-"So Simple It Hurts."

A Ulysses for the 21st century.

 

[S.J.B.]

Salvindolin elicits opioid system-mediated antinociceptive and antidepressant-like activities
Corresponding author: James O. Fajemiroye (Department of Pharmacology, Federal University of Goiás, Goiânia, Brazil)
Journal of Psychopharmacology 2019, Volume 33, Issue 7, Pages 865-881
Published online June 13th, 2019
https://doi.org/10.1177/0269881119849821

Background:

Salvinorin A is known as a highly selective kappa opioid receptor agonist with antinociceptive but mostly pro-depressive effects.

Aims:

In this article, we present its new semisynthetic analog with preferential mu opioid affinity, and promising antinociceptive, as well as antidepressant-like activities.

Methods:

Competitive binding studies were performed for salvindolin with kappa opioid and mu opioid. The mouse model of nociception (acetic-acid-induced writhing, formalin, and hot plate tests), depression (forced swim and tail suspension tests), and the open field test, were used to evaluate antinociceptive, antidepressant-like, and locomotion effects, respectively, of salvindolin. We built a 3-D molecular model of the kappa opioid receptor, using a mu opioid X-ray crystal structure as a template, and docked salvindolin into the two proteins.

Results/outcomes:

Salvindolin showed affinity towards kappa opioid and mu opioid receptors but with 100-fold mu opioid preference. Tests of salvindolin in mice revealed good oral bioavailability, antinociceptive, and antidepressive-like effects, without locomotor incoordination. Docking of salvindolin showed strong interactions with the mu opioid receptor which matched well with experimental binding data. Salvindolin-induced behavioral changes in the hot plate and forced swim tests were attenuated by naloxone (nonselective opioid receptor antagonist) and/or naloxonazine (selective mu opioid receptor antagonist) but not by nor-binaltorphimine (selective kappa opioid receptor antagonist). In addition, WAY100635 (a selective serotonin 1A receptor antagonist) blocked the antidepressant-like effect of salvindolin.

Conclusions/interpretation:

By simple chemical modification, we were able to modulate the pharmacological profile of salvinorin A, a highly selective kappa opioid receptor agonist, to salvindolin, a ligand with preferential mu opioid receptor affinity and activity on the serotonin 1A receptor. With its significant antinociceptive and antidepressive-like activities, salvindolin has the potential to be an analgesic and/or antidepressant drug candidate.

 

[negrogesic]

NINXSXES
N-methyl-1,2,3,4,11,12-hexahydromorphinan

-bare bones opioid
-"So Simple It Hurts."

A Ulysses for the 21st century.

Dresden, what is the compound that is "motivating" (or, inducing) your prolificity in compound creation, and where can I obtain some?

 

[Dresden]

Come over and hang out? Some kind of very high fine frequency non amphetamine stimulant if I had to guess. I rarely do the same 'research' chemical 2x.

If I had to guess, I would say

CRUNK MUFFIN

But whatever it was, it was more intellectual, chill, introspective, delicate, and intelligent than crunky. No se.

DRUIDY DREW?

werd

Peace Out People.

It's

GROOVY I Guess.

1-(4-carbomethoxyindol-3-yl)-2-dimethylaminoethane

I'm Having Too Much

FUN. I Realized It Last Night!

1-(5-carbomethoxyindol-3-yl)-2-dimethylaminoethane

GIMEL

2-[(aminocarbonyl)oxy]-N,N-dimethyl-1-propanamine

a parasympathetic nootropic

* * *

lLLUMIN
3,4,5-trimethoxyphenyl piperidin-4-yl ether

* * *

FOXY ORTHO CARBOMETHOXY
FOCM
1-(2-carbomethoxyphenyl)-2-aminopropane
CMAP

May be a longshot.

* * *

HARD HEADED
piperidin-4-yl 4-methylphenyl ether

probably strong AF

DAVIS
1-dimethylamino-2-(2-thiaindol-3-yl)ethane

DEBOW
(3-methoxy-4,5-methylenedioxyphenyl) piperidin-4-yl ether

PENNINGTON
48
1-(4-pentylphenyl)-2-methylaminopropane

PURDUE
N-methyl-3,4-di-chloromorphinan

A la recherche du temps purdu: The Raving 1990s.

ECHO
3-chlorophenyl piperidin-4-yl ether
-makes 3's (Sagittarius, Jupiter) "Cee the
L-ight"

The Universe Is Like An Echo.
Eventually, You Get Back What You Give.

ECHOLALIA
4-chlorophenyl piperidin-4-yl ether
makes 4's (Aquarius, Ouranos) 'Cee the Light'

SE7EN
-makes 7's see the light
1-dimethylamino-2-(7-chloroindol-3-yl)ethane

SAMMY
13-chloro-N,N-diethyllysergamide
makes the 13th tribe (1st 10 degrees of Scorpio) 'see the light.'
Best taken on Halloween
If that one's inactive, substitute 12-Cl-LSD. Should work fine then.

 

[Dresden]

PINNACLEAR, an antipsychotic.
5-oxa-11-(4-methyl-1-piperazinyl)-8-carbomethoxydibenzo-2,5-diazepine

When Only The Best Will Suffice.

LEAN
5-oxa-11-(2-methyl-2-aminoethyl)-8-carbomethoxydibenzo-2,5-diazepine

Like promethazine, but better.

TOUCAN SAM, a carbamate
N-carbomethoxy-1-phenyl-2-aminopropane


The B-Boys, "Flute Loop:"

PAPAVERAMOS
1,2,3,4-tetrahydro-1-piperonyl-6,7-methylenedioxyisoquinoline
Inspired by papaverine
Probable Erectile Dysfunction Remedy
May be psychoactive as well

SOMAREVAPAP
1,2,3,4-tetrahydro-3-methyl-1-benzylisoquinoline
Possibly A Stimulant

DEV
1-oxo-1-(3,4-methylenedioxyphenyl)-1-(4-oxopiperidin-2-yl)methane

REV
1-phenyl-1-(4-oxopiperidin-2-yl)methanone

TESLA
N-(2-propyl-2-(1-pyrrolidinyl)-1-oxoethyl)-10,11-dihydro-10-oxo-dibenz[b,f]azepine
Inspired by Trileptal (oxcarbazepine)
Intoxicant

 

[negrogesic]

My question is, where are all the psychedelic propylhexedrine analogues?

 

[polymath]

G. E. DiCarlo et al. "Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors", J Clin Invest. 2019. https://doi.org/10.1172/JCI127411.

Abstract

The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT) ensures the phasic nature of the DA signal, which underlies the ability of DA to encode reward prediction error, thereby driving motivation, attention, and behavioral learning. Disruptions to the DA system are implicated in a number of neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD) and, more recently, autism spectrum disorder (ASD). An ASD-associated de novo mutation in the SLC6A3 gene resulting in a threonine-to-methionine substitution at site 356 (DAT T356M) was recently identified and has been shown to drive persistent reverse transport of DA (i.e., anomalous DA efflux) in transfected cells and to drive hyperlocomotion in Drosophila melanogaster. A corresponding mutation in the leucine transporter, a DAT-homologous transporter, promotes an outward-facing transporter conformation upon substrate binding, a conformation possibly underlying anomalous DA efflux. Here, we investigated in vivo the impact of this ASD-associated mutation on DA signaling and ASD-associated behaviors. We found that mice homozygous for this mutation displayed impaired striatal DA neurotransmission and altered DA-dependent behaviors that correspond with some of the behavioral phenotypes observed in ASD.

 

[Dresden]

The Color

MURPLE

1,3,7-triethylxanthine
designer caffeine

OPRAH
1-ethyl-3,7-dimethylxanthine
designer theobromine

STONE
7-ethyl-1,3-dimethylxanthine
designer theophylline

THE MAD HATTER
methyl (4-(2-aminopropyl)phenyl)-mercury

Possible antimicrobial for treatment resistant bacteria
Similar to thimerosal

The Difference Between A Drug And A Poison Is The Dosage.

MODERATORS: Sorry For Posting Another Bulky Pic, But These Molecules Are Hard For Me To Name IUPACically.

Edit: Removed Bulky Pic

Ok, I'm Working On It, And I Am A Can Do!

CAPTAIN.HEROIN
(not an opiate)
N-methyl-7-carbomethoxy-8-azabenzobicyclo[3.2.1]octane

MELINDA
N-methyl-7-carbomethoxy-8-aza(4,5-methylenedioxy)benzobicyclo[3.2.1]octane

In order to use opsin, an iupac-ish name must be assigned. Some molecules such as this one, I cannot figure out how to name iupacishly. Will posting thumbnail sized pics such as the following be acceptable in such
instances?



N-methylbenzomorphan

 

[negrogesic]

How about a ganaxalone analog in homage to negrogesic (though the SAR of these neuroactive steroids is probably pretty esoteric)

 

[Dresden]

I'll see what I can do!

Ok, I'm back. Here goes:

 

[S.J.B.]

Will posting thumbnail sized pics such as the following be acceptabl

Yeah, that's fine. You will get clearer pictures out of a molecular structure drawing program, however. Try searching for "free ChemDraw alternatives" on Google. I'm sure there's something decent out there.

 

[negrogesic]

I'll see what I can do!

Ok, I'm back. Here goes:

View attachment 13382

If only someone could come up with a steroid that was both GABAergic and highly anabolic. Optimally it would combine in equal measure trenbolone-like roid rage with the GABAergic disinhibition of pentobarbital and turn the mildest mannered of men into rapists.

 

[Dresden]

Viola?!
GABA-T.



The Bottom One--THGHBC--Is Reserved For Stoned, Sloppy Recreational, Or Should I Say Procreational, Purposes!!!!

Though, Strictly Speaking, They Are Both Lactones (in this case, GBL's), Not A GABA Or A GHB.

* * *

Ok, Now You Know I'm Gettin' Silly. (But Not Really.)





Notice That These Last 2 'amino' [A Mean-O] Moieties--MAMOGBLT & MAMOGBLTHC, for short--Are Also PEA's [of sorts]!



HOMO_ERECTUS
possible non binary alkaloidal lactone sex hormone and intoxicant



BLUE_SAPPHIRE

For That Special Lesbian In Your Life!



BIG_T
For Macho, Macho Men!

It Keeps Lasting And Lasting And Lasting!!

 

[negrogesic]

If only you could throw in some PDE5 inhibition you'd have a real party

 

[Dresden]

Sildenafil sold separately. :/

The ROMULAN
1-(3,4-methylenedioxy-5-isopropylphenyl)-2-aminopropane

Inspired by the substitution pattern found in certain fractions of rosemary oil



The ROMULAN: Just wow. Super level headed MDA like stimulus.

CRITTER
1-(3,5-dimethoxy-4-isopropylphenyl)-2-aminoethane

Rehab Is For Critters.

BILLY KLINGON
1-(3,4-methylenedioxy-5-isopropylphenyl)-2-methylaminopropane

CLAY VULCAN
1-(3,4-methylenedioxy-5-isopropylphenyl)-2-ethylaminopropane

2 emcees cannot occupy the same space at the same time. It goes against the universal law of psychics.

SHEILA

WONDER WOMAN
1-(3,4-dideuterophenyl)-2-ethylamino-1,1-dideuteropropane

AENEAS
4-carbomethoxypiperidine-4-yl phenyl ether

EROS
4-carbomethoxypiperidine-4-yl 3,4-methylenedioxyphenyl ether

ESAU
1-(2-(3,4-methylenedioxyphenyl)-1-methylethyl)-4-carbomethoxypiperidine-4-yl 3,4-diacetoxyphenyl ether

COCACATHINONE
2-carbomethoxy-3-(oxobenzyl)tropane

SMOOTH OPERATOR
2-carbomethoxy-3-(benzyloxy)tropane

MORGASM
3,4-dicarbomethoxyphenyl piperidin-4-yl ether

MC ESCHER
3,4,5-tricarbomethoxyphenyl piperidin-4-yl ether

YEH, BABY!
1-carbomethoxy-1-(piperidin-2-yl)-1-(3,4-dicarbomethoxyphenyl)methane

Now We're Talking Recovery.

JACKSON POLLACK No. 5
1-carbomethoxy-1-((4-phenoxy)piperidin-2-yl)-1-(3,4-dicarbomethoxyphenyl)methane


More Will Be Revealed.

For example,

RALPH, my cat.
1 -(3,4-dicarbomethoxyphenyl)-2-methylaminopropane

And Lettuce Not Forget

BAM BAM
1-(2,4,6-tricarbomethoxyphenyl)-2-aminopropane

TRON
1-methylamino-1-(2-chlorophenyl)-2,4,6-tricarbomethoxycyclohexane

Indeed, All The CycloHEXanes Are Witches!

Just To Poly Iterate: I'd Still Rather Have Focalin!

BOB NANCE BENNETT
1-(2,6-dimethoxy-4-bromophenyl)-2-amino-1-methoxypropane

C'est une pipe!

SubGeniuses Aren't Necessarily Smarter Than Other People, JUST BETTER!!!

Praise BOB!

MOONEY Family Values
1-(2,5-dimethoxy-4-(2-carbomethoxyethyl)phenyl)-2-aminopropane

HYACINTH
1-phenyl-1-methoxy-1-(piperidine-2-yl)methane

2-AminoPropane
Not quite sure how that one got there. It might make a nice smelling salt, though!

PEPPERMINT PATTY
1-(3-oxo-4-isopropylcyclohexyl)-2-methylaminopropane

SWEET_WATER_420
5-carbomethoxy-1-methyl-3-(2-hydroxy-4-(ethyloxyethyl)-6-isopropoxyphenyl)cyclohex-1-ene

INSATIABLE SATYR
1-(3,4-methylenedioxyphenyl)1-oxo-2-dicyclopropylaminopentane

FAIR NYMPH
1-phenyl-1-oxo-2-diethylaminopentane

NYMPHOMANIAC
1-(3,4-methylenedioxyphenyl)-1-oxo-2-ethylaminopentane

PIP
1-phenyl-1-oxo-2-(1-piperidinyl)pentane

NOMENCLATURIST
7-chloro-5-(4-methylpiperazinyl)-2-oxo-3-hydroxy-1,3-dihydro-1,4-benzodiazepine!
a major tranquilizer / anti psychotic / sleeping pill

SASQUATCH
7-chloro-5-(4-methylpiperazinyl)-2,3-methylenedioxy-1H-1,4-benzodiazepine
ibid.

'Apollo 69' by the TKK.


Feeling the call of the needle's injection? Try this:

DESIGNER NOVOCAINE/PROCAINE
Phenylcarbonyloxyethyldiethylamine
Novocaine/Procaine minus the aromatic NH3 group.

TAYLOR ROYAL
Phenylcarbonyloxy-2-(1-pyrrolidinyl)propane

DURA CANE
Phenylcarbonyloxy-2-(1-pyrrolidinyl)-1-methylpropane

UNCLE RONNIE
Phenyloxycarbonyl-1-methyl-2-(1-pyrrolidinyl)propane

STEPHANIE AVERA
3,4-methylenedioxyphenyloxycarbonyl-2-(pyrrolidin-1-yl)-1-methylpropane

MACGYVER
1-(2-methylthio-3,4-dichlorophenyl)-2-methylaminopropane

Adding AMP to 3,4-di-Cl-AMP (and also to 2-MeS-3,4-di-Cl-AMP) was a great addition. The nor-methyl homologues were much less stimmy without bare speed. However,
N-methyl-3,4-di-Cl-AMP was incredibly surgey without any adderall. I am cautiously optimistic that the situation will be the same here, i.e. from MEGAN --> MACGYVER.

VENUS APHRODITE LOVE
1-(3,4-di-chlorophenyl)-2-ethylaminopropane

I have done the proverbial lion's share of amp, meth, and coke so far in my lifetime but have only taken a total of 500 or so mg of ethylamphetamine before. Ethamp was stronger, smoother, and I'd say preferable to meth, save for its comedown, which was despairingly *horrendous* imo. Can't wait to taste this bitter beauty!

SUG KNIGHT
3,4,5-trimethoxyphenyl piperidin-4-yl ether

I Have Great Expectations By Charles Dickens For This One. May Cause Nausea By Franz Kafka.

WILSON

All Work And No Play Makes Jack a Dull Boy

CAPTAIN KIRKCUM HARRELSON

"90% Of Success Is Just Showing Up."

EMINEM
3,4-dichlorophenyl piperidin-4yl ether

Betcha Didn't See This One Coming...

SHANA
piperidin-4-yl 3,4,5-trichlorophenylthioether

ARIN
3,4-methylenedioxyphenyl piperidine-4-ylthioether

Nice, Very Nice.

CASSIOPEIA
3,4,5-trimethoxyphenyl piperidin-4-yl thioether

One Of My Angels.

NUT (long U)
3,4-methylenedioxy-5-methoxyphenyl piperidin-4-yl thioether

J.R. BOB DOBBS
piperidin-4-yl 3-methoxy-4-methylphenyl thioether

Church Of The Sub Genius.
Subgenii Are Not Necessarily Smarter Than Other People, Just BETTER.

LARRY WOTAN
1-methyl-4-carbomethoxy-piperidin-4-yl 5-methylindol-3-yl thioether

Looking Away It's Another Day.
And Of Course I Love You!

4REALLYIUM [4'-oxa-cocaine]
2-carbomethoxy-3-(pyrylium-4-yl)tropane

Ah, Clean Burning Tropane!

DESIGNER METHADONE
by AMP
2-dimethylamino-4-(3,4-methylenedioxyphenyl)-4-phenyl-4-carbomethoxybutane

Yall Ain't Seen Nutting Yet...

MWOWM
1-(2-(3-indolyl)ethyl)-4-(N-(1-oxopropyl)anilino)-piperidine

 

[S.J.B.]

Novel Dimethyltyrosine–Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism
Corresponding author: Henry I. Mosberg (Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, United States)
ACS Chemical Neuroscience 2019, Volume 10, Issue 8, Pages 3682-3689
Published online June 14th, 2019
https://doi.org/10.1021/acschemneuro.9b00250

The dimethyltyrosine–tetrahydroisoquinoline (Dmt-Tiq) scaffold was originally developed in the production of selective delta opioid receptor (DOR) antagonists. Installation of a 7-benzyl pendant on the tetrahydroisoquinoline core of this classic opioid scaffold introduced kappa opioid receptor (KOR) agonism. Further modification of this pendant resulted in retention of KOR agonism and the addition of mu opioid receptor (MOR) partial agonism, a bifunctional profile with potential to be used in the treatment of cocaine addiction.

The following compound was the most potent mu agonist in the paper:

 

[negrogesic]

I feel like one in homage to the late jeff Epstein would be fitting (although he and his investigator, Attorney General Barr, already share their names with the illustrious human herpes virus 4, Epstein-Barr).

Perhaps a diphenylprolinol derivative, "Espteinol" given the diphenyl (he seemed like the kind of guy who was a "DP" enthusiast).)

 

[Rectify]

ESPTEINOL
1,1-diphenyl-1-methoxy-1-(2-pyrrolidinyl)-methane

HARLEY DAVIDSON
1-(3,4,5-trinitrophenyl)-2-aminoethane

CHRIS BOBSON
1-(3,4,5-tribromophenyl)-2-aminoethane

I Never Said That Drugs Were Healthy.

DESIGNER B3
N,N-diethyl-3-pyridinecarboxamide

SONDRA
1-phenyl-1-methoxy-1-(2-piperidinyl)methane

DAVE
1-methoxy-1-(2-pyrrolidinyl)-1-phenylmethane

The Pyrrolidinyl Drugs Are Subtle But Exquisite With Less Bass In Your Face Central Nervous System Stimulation Than The Piperidines Have.

JHVH-1
1-phenyl-1-carbomethoxy-1-(azepane-2-yl)methane

Terra Incognita

MARCUS
1-phenyl-1-(piperazin-1-yl)methanone

CASEY
1-phenyl-1-(piperidine-4-yl)methanone

CYNTHIA
benzyl piperidin-4yl ether

CINDY
piperonyl piperidin-4yl ether

LOGICAL
1-Phenyl-1-oxa-2-(4-piperidinyl)propane

PROGRESSION
1-(3,4-methylenedioxyphenyl)-1-oxa-2-(4-piperidinyl)propane

May Cause Vertical Nystagmus:

MARK
1-(4-methylindol-3-yl)-2-aminopropane

ANDREW
phenyl piperidin-4-yl ether

DESIGNER ASPIRIN
potassium 4-acetoxybenzoate

STAC(I/EY/Y)
1-(3-chloro-4,5-methylenedioxyphenyl)-2-ethylaminopropane

EPIMETHEUS
2-methyl-4-(2-methylaminopropyl)-thieno[2,3-b][1,5]benzodiazepine

OLLIE
2-methyl-4-(1-carbomethoxy-1-(2-piperidinyl)methyl)-thieno[2,3-b][1,5]benzodiazepine

LEVIATHAN
2-methyl-4-(1-oxo-2-(1-pyrrolidinyl)pentyl)-thieno[2,3-b][1,5]benzodiazepine

KING SOLOMON
2-methyl-4-(2-dimethylaminoethyl)-thieno[2,3-b][1,5]benzodiazepine

And Visions Of

SUGAR PLUMs
1-(2-methylthio-3,4-methylenedioxyphenyl)-2-aminopropane

Danced In Their Heads.

EINSTEIN
3,5-dicarbomethoxy-piperidine-4-yl benzyl ether

MICHAEL
4-propylthio-3-methoxyphenyl piperidine-4-yl ether

Achtung, baby!

Cynthia & Druidy Drew Are Good To The Last
D
R
O
P
!

* * *

This Next Series I Have Dubbed, THE HEAVENLY BLUES:

HARVARD
6-azuleneyl-amphetamine aka
6-(2-aminopropyl)-azulene

HOGAN
6-(2-methylaminopropyl)-azulene

LOGAN
6-(2-ethylaminopropyl)-azulene

STALLONE
1-(azulene-6-yl)-1-carbomethoxy-1-(2-piperidinyl)-methane

SCHWARZENEGGER
1-(azulene-6-yl)-1-carbomethoxy-1-(2-pyrrolidinyl)-methane

DOOLEY
1-(azulene-6-yl)-1-oxo-2-(1-pyrrolidinyl)pentane

BOLIVIAN MARCHING POWDER
3-((azulene-6-yl)carbonyloxy)-2-carbomethoxytropane

MOTHER'S LITTLE HELPER
4-methyl-8-(2-chlorophenyl)-5-oxo-2-methyl-4,7-diaza-azulene

GARGAMEL
3-(2-dimethylaminoethyl)-1-aza-azulene

AZRAEL
3-(2-aminopropyl)-1-aza-azulene

I'm Azrael!

4-MMCAT
1-(4-methylphenyl)-2-methylamino-1-oxopropane

Meow! [Cat language for, 'Please!']

BRITNEY
N-(2-hydroxyethyl)-1-phenyl-2-aminopropane

Verdict: BRITNEY IS OFF THE CHARTS.

Although this last one is a somewhat admittedly nebulous ideation, if she works I think Imma gonna love it!

HANK AARONSON
N-hydroxy-1-phenyl-2-propylaminopropane

K-FED
N-(2-hydroxyethyl)-1-(3,4-methylenedioxyphenyl)-2-aminopropane

LICKER
1-(1-pentylindol-3-yl)-1-(2-hydroxyethyl-3-methylpiperidin-4-yl)methanone

CANDY IS DANDY, BUT LICKER IS QUICKER.

DAFFY
N,N-di-(2-hydroxyethyl)-1-(indole-3-yl)-2-amino-2-oxoethane

NEW EBENEEZER
N,N-di-(2-hydroxyethyl)lysergamide

QUICK TRIP, a carbamate.
1-(3-indolyl)-2-dimethylamino-1-oxa-2-oxoethane

LIL INDRA
N-(2-hydroxyethyl)-1-(3,4-dichlorophenyl)-2-aminopropane
The Little Injun That Can!

CADDY
N-(2-hydroxyethyl)-1-(2-methoxy-3,4-dichlorophenyl)-2-amino-1-methoxypropane

When I Smoked Your Dro, I Was in The Caddy, Bro.

ISAIAH
1-(4-iodophenyl)-2-(2-hydroxyethylamino)propane

AMOS
1-(4-methoxyphenyl)-2-(2-hydroxyethylamino)propane

AMOS IS SOMA SPELLED BACKWARDS.

BARNEY
1-(4-methylphenyl)-2-(2-hydroxyethylamino)propane

Scratch all yesterday's novel
R-NH-CH2CH3-OH amphetamines (and presumably, tryptamines). While not completely inactive or weak, they seem to be difficult to qualitatively categorize effectively with words and are not super rewarding in my humble opinion.

 

[sekio]

J Ethnopharmacol. 2019 Nov 15;244:112151. doi: 10.1016/j.jep.2019.112151. Epub 2019 Aug 9.
Sagas of the Solanaceae: Speculative ethnobotanical perspectives on the Norse berserkers.
Fatur K

ETHNOPHARMACOLOGICAL RELEVANCE:

The Norse berserkers were wild warriors of Scandinavia known to enter a trance-like state that allowed them to fight with increased strength and a rage that granted them immunity to many forms of harm in battle. Though many theories have been advanced as to the cause of this state, the most widely believed is that the intoxicating mushroom Amanita muscaria was used.

AIM OF THE STUDY:

The following article underlines the issues with this theory and provides an alternate intoxicant that fits with the reports of berserker behaviour much better: Hyoscyamus niger.

MATERIALS AND METHODS:

Literature from a variety of disciplines pertaining to history, toxicology, pharmacology, and botany was compiled to frame and support the argument.

RESULTS:

H. niger proved to be a more likely intoxicant used to induce the berserker rage state.

CONCLUSIONS:

With its anticholinergic tropane alkaloids and symptom profile, H. niger is a much more likely cause of the berserker state than A muscaria. Though there is not enough archaeological and historical evidence to prove or disprove this theory, it provides a novel explanation that is at present the most viable means of understanding the berserkers' trance.

My love for you is like a truck, Berserker
Would you like some making fuck, Berserker

 

[Rectify]

Awakening The Giants:

CRONOS
N-(piperidine-4-yl)aniline
ein bitte amine

RHEA
3,4-methylenedioxy-N-(piperidine-4-yl)aniline

Nothing's Gonna Stop Tha Flo O Oh...

It's Only Right That You Pay Homage To Those That Are About To Blow Like The Stuff Up Your Nose!

HELIOS
4-methoxy-N-(piperidine-4-yl)-N-carbomethoxyaniline

These Smiling Eyes Are Just A Mirror For The Sun.

OURANOS
3,4,5-trimethoxy-N-(piperidine-4-yl)aniline

World, Hold On. Someday You Will Have To Answer To The Children Of The Sky.

BEVERLY
piperidin-4-yl toluene

HILTON
piperidin-4-yl 3,4-methylenedioxy toluene

Smooth & Sleek.

RUSSELL CROWEACINAMINE
1-(2-methoxy-3,4-methylenedioxyphenyl)-2-aminopropane

CROWEACIN
2-methoxy-3,4-methylenedioxy-1-allylbenzene



:NH3

AMEN RA
ammonia

SAFROLE
3,4-methylenedioxy-1-allylbenzene
aka
5-allyl-1,3-benzodioxole

The DECEPTICON
N,N-di-cyclopropylmethyl-1-(3,4-methylenedioxyphenyl)-1-oxo-2-aminohexane

SHARDY SHARDS
recrystallized (2S)-2-methylamino-1-phenylpropane hydrochloride

DENNY'S BENNY
1-phenyl-1-oxo-2-(1-pyrrolidinyl)propane

KATE'S GR8
1-(3,4-methylenedioxyphenyl)-1-oxo-2-(1-pyrrolidinyl)propane

PROLETARIAT ('PRO-LITERATE')
1-phenyl-2-(pyrrolidin-1-yl)propane

FIDGETTY
1-carbomethoxy-1-phenyl-2-(pyrrolidin-1-yl)propane

RICO SUAVE
1-(3,4-methylenedioxyphenyl)-2-(pyrrolidin-1-yl)propane

PARA-BENZOQUINONE
1,4-di-oxo-cyclo-2,5-dieneylhexane

HYDROQUINONE
1,4-dihydroxybenzene

PIPERONAL
5-methanonyl-1,3-benzodioxole

Great Expectations by Charles Dickens

PYRROLIDINE
1-azacyclopentane

PIPERIDINE
1-aza-cyclohexane

MDPV-fentanyl
N-phenyl-N-(1-oxopropyl)-N-((1-propyl-2-(3,4-methylenedioxyphenyl)-2-oxoethyl)piperidine-4-yl) amine

N,N-DiMethylTryptamine_DMT: The Spirit Molecule.
1-(indole-3-yl)-2-dimethylaminoethane

Mimosa hostilis

Good Night!

DEEP
N,N-diphenyl-(1-((4-methylindole-3-yl)-ethyl)-4-carbomethoxypiperidine-4-yl)amine

Whatsapp?

KHATSUP

BART(HOLOMEW) SIMPSON
1-(3,4,5-tribromophenyl)-1-methoxy-2-aminopropane

STU(ART) GRIFFIN
1-(4,5-dibromo-2-methoxyphenyl)-1-methoxy-2-aminopropane

How Great Thou



I Ride Around Town On My Low Rider Tricycle.

NORTH DRUID HILLS
1-(2-hydroxy-4-pentyl-6-methoxyphenyl)-2-aminopropane

Ahh...Clean Burning Propane!

In other news, is it just me or is this one not

OBVIOUS?
N,N-di-(2-hydroxyethyl)-lysergamide

ANANDAMIDE
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide

CHANEL No. Z
(5Z,8Z,11Z,14Z)-N,N-diethylicosa-5,8,11,14-tetraenamide

ARMANI A/X
(5Z,8Z,11Z,14Z)-N,N-di-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide

Intelligent Design

JUAN
1-(1-pentylindol-3-yl)-1-(diethylamino)methanone

MARY
1-(4-piperidinyl)-1-(4-methylindol-3-yl)methanone

delta-9-THC = MARY i JUAN a
"Mary & John"

Like Maxwell House, I Am Good To The Last

DROP
1-(5-oxo-imidazo [1,2-a]pyridin-3-yl)-2-dimethylaminoethane

MAURICE
1-(1-piperazinyl)-1-(3-methoxyphenyl)cyclohexane

It's A Hex!

EL SHAOSHYANT
3-ethyl-8-methoxy-1,2,3,4,5,6,7,N-octahydroindolo[2,3-a]quinolizin-2-yl phenyl ether
(designer mitragynine)

Eureka!!!

DOPAMINE
1-(3,4-dihydroxyphenyl)-2-aminoethane

The Gate Way Drug!!!!

People, How You Doing?! It's A Brand New Morning!

NOVACANE (song/drug) by BECK
2-(dimethylamino)ethylbenzoate

Not to be confused with NOVACAINE (procaine).