Caapi alkaloids by Callaway 2005.pdf (1,087,349 bytes)
3 downloads [
Copyrighted?]
Remember, in case you don't want to use this sublingually (my preference) you can always stir your HPBCD DMT once you form it on a spoon in one minute into around 1 oz or 1-shot glass full of hot water, stir it, the water will remain clear, as the HPBCD DMT dissolves instantly. Then add 200mg harmine + 200mg THH to the 1 oz of water, add a pinch of crushed vitamin C so the freebase harmalas will dissolve, stir for a few seconds, then consume all at once just as the Shaman's do for the most powerful experience...45 minutes later the Ayahuasca will begin to work.
Using the HPBCD DMT will make the experience just like if you had used potent Hawaiian psychotria leaf, as the HPBCD DMT is all-encompassing and dissolves 2 to 2.5 times (200 to 250%) better than DMT salts, and there is no gastrointestinal irritation like with normal DMT salts, as the HPBCD not only masks the nasty taste of the DMT as you drink it, but it reduces intestinal irritation from the DMT. The oral bioavailability of the HPBCD is very low (0.1 to 3%) because of their bulky and hydrophilic nature, see below:
I used to use potent psychotria directly from Hawaii for a decade until it became super rare present day, and can no longer be found. You will love the HPBCD DMT as it is just as potent, dream come true. Much of the present day Caapi that is used by the plus hundred retreats in Peru is no longer "older caapi" as it can no longer be found, but "younger caapi" which does not contain quite as much natural tetrahydroharmine, so making and using your own THH is also a dream come true. Much of the older caapi that does remain can only be found by venturing deep into the forest to retrieve:
https://entheonation.com/blog/ayahausca-sustainability-caapi-vine/
"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017:
https://www.ema.europa.eu/en/docume...xcipients-medicinal-products-human-use_en.pdf
Cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes.
Cyclodextrins at high doses can increase drug permeability by direct action on sublingual mucosa by up to 400% or intestinal membranes and enhance drug absorption and/or bioavailability. These effects are possibly caused by solubilization of membrane lipids through inclusion complexation with cyclodextrins and the ability of cyclodextrins to cause perturbation of membrane integrity. However, unlike detergents, cyclodextrins solubilize membrane components without entering into the membrane, therefore the perturbing effects of cyclodextrins are mild and reversible [7].Cyclodextrins are absorbed poorly via mucosal membranes.
The oral bioavailability of cyclodextrins is very low in adult animals and humans (0.1–3%), except for RM-β-CD, which has a bioavailability of 12% in rats. Because of their bulky and hydrophilic nature only insignificant amounts of cyclodextrins are absorbed from the gastrointestinal tract by passive diffusion [33, 27].
1st HPBCD DMT capsule Ayahuasca Journey, April 21, 2021 (2 years ago):
-----------------------------------------------------------------------------------
On my very first 300mg oral THH freebase + 200mg harmine freebase mixed into 60mg HPBCD DMT (60mg DMT complexed to x7 or 420mg HPBCD in 6 drops boiling hot water in 1 minute on a spoon) journey with 2 more 100mg harmine + 60mg HPBCD DMT capsule re-doses at each 1.5 hour mark:
...all the way from 8 pm till 1 am in the morning (5 hours) I was seeing closed eye visions of slow and high speed movies...I saw brightly colored serpents, dungeons I traveled thru, many Mesoamerican pyramids, women of incredible beauty, Japanese landscapes, dancing geometrics, many different animals on a rotating globe, walking on the planet-like globe as it spun, hundreds of visions like slow and high-speed movies over the course of many hours.
I wore headphones and listened to music the whole time, as the music sounded just like if I had taken a very strong cactus tea.
I saw the interiors of many magnificent homes, exposed like a camera flash went off, then off to the next home interior, bizarre alien looking creatures, I saw ancient ruins but they were seen as they were before they fell apart. All sorts of architectural wonders appeared that I could not make out exactly what time period they were from.
All the visions were enchanting & manifested incredible beauty. The multi-colored beautiful serpents kept appearing several times in different forms, as if they have some prominence to do with it all, two of them had shining skin covered in gold scales and intertwined like DNA, reminds me of the Aztec quetzalcoatl myth, the "serpent of precious feathers."
...all of these visions were brightly colored due to the oral HPBCD DMT + harmine + THH combo in a single capsule, taking 2 more re-doses all night long..it was one of the most powerful psychedelic experiences of my life...and I've taken Ayahuasca x 90 times, cactus tea 100 times, etc...I have never had over 5 hours of non-stop CEV visions anything close to what I saw that first night.
The visions inspired me to buy a book on the Aztec myth of "Quetzalcoatl, the serpent of precious feathers", as I feel somehow this entity is a "teacher to mankind". I saw the brightly colored serpents many times in the 5 hours of visions, and now I understand why they are so commonly reported in Ayahuasca journeys. They seem to possess divine knowledge that humans were not supposed to have been privileged to, but the serpents gifted this knowledge to humankind.
Recently found a 1.5 hour video on Amazon prime entitled "Ancient Alien Origins" and "Alien gods" 2019 on Amazon prime which is all about this ancient alien flying serpent or dragon entity which is found in all religions of the world & "BAM, Builders of the Ancient Mysteries".
Return of the Serpent & of Eden:
https://earthmedicine2015.wordpress.com/2016/01/29/return-of-the-serpent-of-eden/
Ayahuasca Journey #47 (May-20-2022):
-------------------------------------------------------------------
Dose: 300mg tetrahydroharmine or THH freebase in capsule + 120mg HPBCD DMT covered with x7 or 840mg HPBCD powder, added 12 drops of hot water, mixed and mashed all together using end of another spoon for 1 to 2 minutes) then mixed 200mg harmine into the HPBCD DMT on the spoon and added all this to a single Ayahuasca capsule:
....after 10 minutes of animated super-colorful geometrics, then came the realistic visions: I viewed incredibly beautiful women morphing into other beautiful women, these women changed into nearly 20 different women, completely naked and with animated face changes, infinite beauty, mind blowing CEV's...like the most incredible cartoon renderings of the most beautiful women, they even had geometric swirling pastels on the surface of their bodies...completely blown away. I usually use this capsule ayahuasca at least once a week.
When I say animated, these women smiled and blew kisses and moved into all different positions...like watching a movie. They made intimate eye contact and communicated via physical motions. This was a +5 Shulgin level experience, this felt like direct communication and receiving of important artistic creative feelings and insights into the feminine domain. This is fascinating to me as one of my interest is cartoon drawing and reading cartoon books. Ayahuasca has a tendency to find your interest and show you teaching visions related to them.
I recorded this journey as one of the most visual of my entire life, never have I seen an hour's worth of beautiful women morphing into other women, with swirling geometric pastel patterns on their naked bodies, communicating physically, this is an artist's dream come true, way beyond 4k, visual detail astounding.
I had headphones on, and the music sounded as if I had taken a strong bridgesii cactus tea (18" of bridgesii or around 500mg of mescaline), profound music enhancement, just heavenly, powerful spiritual insights, infinite open eyed beauty and neon colors splashed on all the walls, very powerful experience, it was so strong I started to feel the dmt starting to work in only 30 minutes, incredible blast off, lasted 1.5 hour with very strong trip, with 1 full hour of powerful closed eye visions as stated above. Zero nausea, zero dizziness, zero anxiety.
---------------------------------------------------------------------------------------------------------------
Thank you for likes PsychedelicSummer, OrbitalCombustion, mushinist, bezevo and anonymous user.
Dave Bowman said:
I always thoroughly enjoy your posts, I'll have to try this sooner than later. I'm all for eliminating any of the nausea associated with oral Aya/DMT. Nice work as always.
chris77 said:
Thank you Dave Bowman and chris77 for your kind words, very much appreciated.
L-dreamer is another psychonaut who has worked with this, see his experiences below, he used an earlier method of mine where he would still take 200mg THH orally, but instead of taking 200mg oral harmine along with it in a capsule, he would instead add 30 to 35mg harmine under tongue to use sublingually at exact same time as the sublingual HPBBCD DMT is held under tongue. 30mg sublingual harmine has the potency of x 7 or around 210mg oral harmine, just that the journey or trip is a bit shorter (1 hour) than when using oral harmine. I way prefer using the oral harmine every time now.
I no longer add the 30mg harmine under the tongue, although it works to activate the DMT sublingually, I prefer to take 200mg harmine orally, as it allows for a long duration 1.5 hour long full strength Ayahuasca trip, as it dampens MAO in the brain for a good several hours, and the strength when used with the sublingual HPBCD DMT is unbeatable.
I also find the HPBCD DMT absorbs at full strength under tongue when there is no harmine mixed in with it sublingually. Either method works however, but I recommend now only using the harmine orally taken at same time in a capsule along with your THH or tetrahydroharmine. Then around 1 hour later, only when you feel the harmalas working, mix and apply the HPBCD DMT under your tongue, and hold for 10 to 15 minutes depending on DMT dosage.
You can re-dose more sublingual HPBCD DMT again 1.5 hour later and it continues to work at full strength, as the THH has a half life of 10.5 hours (peak at 5.25 hours) and the harmine half life is long at 1 to 3 hours, you can even take more oral harmine later (75 to 100mg or so, just experiment) anytime during the night to keep the MAO in the brain dampened all evening long if you prefer, just as normal Ayahuasca drinkers often take a second dose.
I have taken more oral harmine during the night before as explained above and kept tripping for 5 hour straight at full strength! It was a phenomenal journey that was one of the best of my entire life. I love long trips. No need to ever take more oral THH as her half life is 10.5 hours.
I prefer to only use harmine and not harmaline, as harmaline is only found in real Caapi based Ayahuasca in trace amounts (zero to 20mg). Harmaline is nauseating and causes sleepiness and dizziness, I prefer only harmine as it does not cause nausea or dizziness for me, and has a mild stimulation effect.
THH or tetrahydroharmine since she blocks serotonin causes mild stimulation and breaks down the barriers or filters and doors of perception or day to day survival filters so that "mind at large" can be let loose. Serotonin blocking also causes stimulation. THH is extremely important in Ayahuasca, Aldous Huxley on mind at large:
https://en.wikipedia...a Mind at Large.
200mg oral THH + 200mg oral harmine + 60mg sublingual or oral HPBCD DMT feels like 300mg mescaline
200mg oral THH + 200mg oral harmine + 90mg sublingual or oral HPBCD DMT feels like 400mg mescaline
200mg oral THH + 200mg oral harmine + 120mg sublingual or oral HPBCD DMT feels like 500mg mescaline
200mg oral THH + 200mg oral harmine + 150mg sublingual or oral HPBCD DMT feels like 600mg mescaline
--> If using 90mg or less sublingual HPBCD DMT, it all absorbs in around 10 minutes, if using 100 to 150mg DMT, it all absorbs 100% in 15 minutes.
--> when you add the HPBCD on top the DMT freebase, and add the drops of hot water from coffee mug, the HPBCD shrinks down to next to nothing on top the DMT, as it is like a sugar cube when a drop of water is added to it. HPBCD Cyclodextrins are ring-shaped molecules made from cornstarch.
Note: Always DRY THE BOTTOM of your tongue with a tissue before applying the sublingual HPBCD DMT. HPBCD can only complex FREEBASE molecules like DMT freebase, testosterone freebase, pro-hormone freebase, etc, and will not complex drug salts.
Note: Chemist Patrick Arnold make an HPBCD complexed 4-androdiol powder that could be placed under tongue, it dissolved with phenomenal results and gave results comparable to steroids, as 4-androdiol pro-hormone was legal at the time and raised testosterone the same as real testosterone complexed to HPBCD and used under tongue. He was granted patents, and made millions of dollar selling his product "cyclodiol" to athletes, see pic 5 of bottle for 10 years until the Gov't made prohormones illegal as they worked as well as steroids.
Oral Harmine + oral THH + sublingual HPBCD DMT is VERY TRIPPY, so be prepared, but she is nothing like mushrooms...she is crystal clear in clarity like mescaline with infinite beauty and extremely visual with open or closed eyes, audial and colorful with divine healing and spirituality. There is none of the confusion or up and down emotional rollercoaster of mushrooms.
Everything shines and shimmers with a diamondlike brilliance & divine inner light from within and colored moving energy fields like a rainbow aura can be seen surrounding everything. Every trip I see neon colors that do not belong on this earth like neon purple-yellows, red-greens, orange-blues.
Colored geometrics fill the walls and surfaces, colored laser like scans can be seen on the walls along with the geometrics, tracers are extreme and like lightening strikes.
Visions with closed eyes start with colored intricate geometrics, hundreds and hundreds of them in variety of neon colors, lots of yellow, blue, red, green, violet, pink....these geometries progress to real visions like in one of my 200mg oral harmine + 300mg oral THH + 120mg sublingual HPBCD DMT journeys where the geometrics gave way at their intersections to naked Egyptian Cat-women and Indian goddesses, I was blown away.
I've flow over medieval landscapes, seen naked women dancing around rotating stone pillars with gold masks held in front of their faces, hundreds of incredible visions over my 2 years of using this sublingual HPBCD over 50 times. I could fill pages with all the visions.
Music lovers like myself will bask in the hours of extreme music enhancement, every sound in the music is literally "epic". Best part is it's cheap but extremely profound. You can save a ton of money using this. 170 grams of bark yields 2.4 grams DMT every time, if you need help easily.
I find it the most potent psychedelic on earth and I've taken LSD hundreds of times, cactus tea over 100 times, and regular oral Ayahuasca over 90 times in 2 decades.
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Compilation of L-dreamer's comments:
"Making this thread so that I can post my thoughts on the dosing method described in tregar's thread
My few experiences have consisted of about 60 mg of freebase DMT dissolved in 500 mg of HPBCD, with 250-300 mg of THH, and about 35 mg of sublingual harmala/harmaline
From the start I want to say that sublingual DMT with oral THH is everything I wanted ayahuasca/pharmahuasca to be. And I think it is also the best way for someone to be introduced to DMT
Where do I start with the pros:
- no nausea at all, even if you take sublingual harmine/harmaline with it. It is such an odd and pleasant feeling to not have to fight constant nausea and vomit inducing dizziness. I literally don't have to worry about having a handy throwup bucket like I did with typical oral DMT.
- just the right kind of duration, it never overstays it's welcome, in about an hour you will get whatever you had to receive. No need for a bedridden 2+ h long comedown
- crisp, clear headspace. Previous oral DMT experiences have always given me this pinch of delirium and sleepiness to my mental state. But with this combo and I am fully present in it
- no come-up anxiety, the transition is gradual and smooth
- the DMT visuals are there, and in one experience they seemed even more glowing, or with actual real-life landscapes or persons assembling before my vision instead of the usual DMT geometry
- your body will love to move to the music you are listening
- let's say you accidental swallow the DMT solution or the saliva build-up becomes unbearable - you will still have a pharmahuasca experience with less if not any nausea. And also this form of oral DMT seems to absorb way better than a typical pharmahuasca
- you need less DMT than the typical pharmahuasca
- if you aborted the experience (saliva build-up that you spit out) you will know in about 25-30 minutes for sure, and then you can try again with the same DMT dosage, it won't stack like in pharmahuasca where it can sometimes take even 2 hours to enter fully
I still can't believe people aren't all over this method, especially beginners. It is so versatile and maybe even "comfortable". It is worth experimenting only on it for me, goodbye throw bucket and tissues next to my bed, goodbye retching and holding in the taste of earthy vomit, goodbye 5 hour long sedation and diziness that takes up your entire day.
I predict in a short time sublingual DMT will have it's separate section on forums.
--------------------------------------------------------------------------------
L-dreamer, post #372:
Had another try today.
Tregar was not kidding with the images of beautiful women. Today I had a vision of a naked blonde with the body of a literal Goddess opening my mind's eye like you would a zipper at the beggining. The perfection of the female form in full display with a glistening astral skin. And it wasn't any libido increase, just a sense of witnessing beauty.
This effect is so peculiar to me, tregar mentioned about certain adrenergic receptors that THH touches like mescaline does, but I could not find a source on how these receptors are actually involved in "Aesthetic perception"
--------------------------------------------------------------------------------
L-dreamer, post #401:
no need to worry, the THH I have is 100% legit. It's just that sublingual DMT requires harmine or harmaline (sublingual or oral) to activate from my testing. At this point I am trying to see how exactly it works and what kind of harmalas are needed. Sublingual DMT isn't like vaped DMT where you don't need harmine or harmaline IMO.
The reasons I know my THH is legit are:
- had actual visions on it+DMT+ sublingual harmalas (even 35 mg can work). Visions of incredibly beautiful women (think Greek goddesses archetypes) are for me one of the hallmarks of THH
- enhances music
- leads to slight dizziness at that dosage but no actual nausea
- powerful mood enhancement for days after I have taken it: less anxiety, and less neuroticism
--------------------------------------------------------------------------------
L-dreamer, post #411:
Writing this post 30 minutes after another sublingual DMT experience. Someone was asking me why am I hoarding grams of DMT. And the reply is that I want to have as many sublingual DMT experiences.
Finally got the pure harmine and the difference is night and day from the harmaline. Way more sharper thought space without the tinges of delirium harmaline brought me, I'm not going back.
I tried two times pharmahuasca but I puked two hours in each time, so the experiences ended way sooner.
I will say that the pharmahuasca is more suited, at least in the dosages I take the DMT with, for self-assessment. It just makes me think about me, my life, and my relationships with others. A lot of times there is barely any fancy light show going on but I am fed spikes of what I feel are insight, that stay with me long after the experience is over. One of the trips dealt with the theme of my parents and brothers, the blood lineage that ties us and the affection that binds a family in cohesion.
Sublingual DMT on the other hand is way more euphoric, sharp and energetic. Pharmahuasca is the boring tea you have to sip that does not taste good, while sublingual DMT is that can of energy drink you just want to gulp in one go.
I have a vape mod but I can honestly say that I am too scared to smoke DMT in any significant dosage. And the lack of harmalas gives the pure DMT landscape a vibe that I consider too chaotic and useless, like those post-modern "pain-t(h)ings" were people just smear paint and call it a day.
Dosage: 120 mg of DMT (without the RE-x), 50 mg of sublingual harmine, 300 mg of THH an hour before. The HPBCD was added according to the instructions of tregar
Held the cotton with the liquid for 8 minutes, all the saliva built up was spit into a cup after. I have to say that, like tregar mentioned, the harmine added to HPBCD alleviated the DMT sting a bit.
Comeup began as soon as I put my sleep mask on. What followed could be described as a display of a dance show. Walls of different chambers were morphing and dancing to the music I was listening. They changed into different body parts such as legs and arms (all with womanly proportions) and were in an perpetual fluidity. Plenty of women figures under disguise, at some point I saw a roman chamber with a white statue morphing. Near the end of the trip a vision of a forest sprang up.
The trip duration was literally to the length of this playlist I was listening during.
https://www.youtube....lgsjV0H9Vmhrbk
10/10 would recommend again."
12 reasons pure THH or tetrahydroharmine rocks:
----------------------------------------------------------------------------------------
0. THH is not an MAOI or a RIMA but a psychedelic serotonin reuptake inhibitor (SRI) found in caapi with many similarities to mescaline. She is a feminine teaching spirit.
There is no tetrahydroharmine in rue seeds, only traditionally used Vegetal Caapi brew in same amounts as harmine usually, but she can be made from harmaline in rue seeds in around 1.5 hour.
1. Post #13 of this paper
https://mycotopia.ne...e-under-tongue/ shows how to convert harmaline to pure THH in 1.5 hour for the first time (very fast) with 75% yield. TIHKAL THH entry also achieved 75% yield. Post also shows how to dip a cue tip in vinegar to wet, take up a bit of the THH, smear on a paper plate to check the blue glow under blacklight to make sure it is pure. Any green in the glow means you still have un-converted harmaline, but follow instructions and you won't have any unconverted.
--> Please do this UV check even if you source THH from China (liftmode paperwork indicates Chinese made), as there have been a few reports of it glowing green and not pure light blue with the vinegar swabbed UV check, indicating there is still harmaline in the THH, it would not be a good idea to take even light amounts of harmaline with your Ayahuasca unless you like nausea, dizziness, you want only pure THH...either make it yourself or source it from a reputable supplier. THH is an SRI and harmaline is a RIMA, completely different substances <--
1. Dennis Mckenna Ph.D: page 67:
https://www.heffter.org/wp-content/uploads/2020/04/chapter10.pdf
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.
In my experience, THH doubles the half-life of DMT, so when used sublingually or orally, you get a full strong 90 minutes out of it with long afterglow.
2. She is in the same beta-carboline family as ibogaine. She is the 2nd highest alkaloid in Caapi. She has a 10.5 hour half-life with peak at 5.25 hours.
3. DMT only colors are subdued and dark, but THH brightens the DMT visuals: out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + moderate dose 60 to 70mg+ sublingual or oral HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.
4. DMT does not block serotonin on it's own, but THH does...this results in not only stimulation but euphoria in combo with the DMT: and real Ayahuasca visions become apparent...important teamwork. Ibogaine, LSD, mescaline, shrooms, 5-meo-dmt, bufotenin in Amazonian snuffs, all block serotonin, THH blocks serotonin.
5. THH has numerous similarities to mescaline, she is like the beta-carboline version of mescaline, few people have used her over 100mg. I have seen the receptorome chart for THH vs. mescaline. She not only blocks serotonin like mescaline, but agonizes all 3 adrenal receptors A1-A3 associated with beauty and aesthetic enhancement, just like mescaline. Beauty enhancement is "over the top" when THH is included, she is diamondlike shimmering in her beauty.
Actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the THH. Researchers have called THH the "tryptamine of the beta-carboline world" and rightly so.
6. THH is found in average 150mg in a cup of Caapi based Ayahuasca tea, when 2 cups are drank by some of the more advanced members for evening at the vegetals (UDV, Santo Daime, Shuar Indian) people are consuming around 300mg of THH.
7. Music will only sound bad-ass incredible if you include from 150mg to 300mg oral THH with your sublingual or oral DMT. Listening to music on THH + DMT is like listening to music on high dose cactus tea: heavenly, infinitely beautiful music enhancement, every voice and instrument stands out on it's own, like hearing a song for the very first time.
8. This pure THH at 300mg all by herself is extremely visual, she's an isomer of a hormone like substance made in the brain naturally.
9. The entry in TIHKAL for 300mg THH is completely wrong, where the unexperienced person compares it to the effects of 100mg harmaline. She is nothing at all like harmaline, and like 69ron once said about the person's comment in TIHKAL, he or she would not be able to tell their ass from their elbow. I agree, what complete nonsense. Dr. Shulgin wrote that he never got the chance to try THH, but wrote that more studies on it are "badly needed."
10. professor8 (found here from 11/1/2010 he writes like a poet w/special powers of imagination & expression):
A while back I read a very good explanation of the different effects of Harmalas that has stuck with me. I believe it was 69ron that said: ‘Harmine is the Coffee of the harmalas & Harmaline is the Weed and when it comes to THH (tetrahydroharmine) you have The Light.'
While very similar in molecular structure, THH has a completely different personality to Harmine & Harmaline. Calling it The Light of the harmalas is very appropriate. IMHO, it is the Holy Grail of The Harmalas. I have found Harmine very, very helpful in Meditation & Yoga. It energises your Light Body and allows you to see your Chakras & Auric fields; very helpful in a biofeedback sorta way.
Personally, Harmaline is too heavy & stony for me but I do respect its power and personality, kinda like a big shaggy & lovable dog.
Tetrahydroharmine (THH) has the ability to raise your vibration in a most powerful, yet subtle way. It brings a crystalline prismy texture to spice and adds a super clear watery dimension to Aya, like looking down through 10meters of shimmering Caribbean Sea on clear blue day. It brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order. If one is not accustomed to perceiving these experiences with a spiritual perspective most of the nuances & subtleties THH brings on are overlooked and remain unseen and one would better enjoy Harmaline as a house painter chooses a roller over a brush, its about preference & choice..
Espiridion:
Tetrahydroharmine is much more like mescaline.
11. Trips (from here on 12/2/2011):
As to how the THH altered the experience -> I find rue extract+DMT to be very similar to mushrooms. I found the THH added to the rue+DMT to shift the experience to a state much closer to that provided by LSD. It was more clear, more energetic, more focused, more euphoric, and when confusion struck it was definitely more "acid-like".
The world is moving in the direction of the Left Brain: technology and science. What the world needs is to move in the direction of Right Brain development: empathy, spirituality, connectedness. Compounds like tetrahydroharmine in Caapi could be said to improve emotional intelligence. Is this component of caapi a smart-nutrient for the right side of the brain? you be the judge.
At 300mg of THH all by itself, there are heavy open-eyed tracers like lightening flashes, and hours of teaching closed eye visions that start with colored sparkles and fireworks (red, green, yellow, blue) that dart around and progress into full-fledged way-beyond 4k visions with eyes closed that are not only static but often animated like slow and high speed movies, but all one monochrome color like green or blue for me, when you add DMT, the visions then become colored and patterning on animals for example will display their associated colors, DMT also adds on to or builds on top the THH visions, expanding them, but the teachings and insights & visions are credited to the Vine, just as Gayle Highpine writes in linked paper:
12. Gayle Highpine (Ayahuasca researcher):
http://www.ayahuasca...n-of-ayahuasca/
The vine carries the content of the message, the teaching, and the insight. The purpose of drinking Ayahuasca is to receive the message the vine imparts.
Page 154 of "Various Alkaloid Profiles in Decoctions of Banisteriopsis Caapi, 2005":
https://kodu.ut.ee/~...allaway2005.pdf
The average ratio of THH to harmine in the vegetals (traditional brews) was consistently near 1:1, from all sources (table 2), while this ratio was closer to 1:5 in a large survey of source plant material. It is presently unclear whether harmaline is being chemically reduced to THH during the acidic process of decoction.
Dr. Callaway wrote in "The Entheogen Review":
However, in a broad (as yet unpublished) survey of Banisteriopsis caapi, Psychotria viridis and subsequent teas, which included phytochemical analyses of all, plus subjective ratings of the teas, a strong correlation was found with teas that contained high amounts of THH and not DMT! This rating was from a large body of experienced users (regular União).
HH blocks serotonin, just like all the major natural oral psychedelics, serotonin blocking results in stimulation, breaking down of barriers and filters, direct access to divine spiritual world, increased visionary power, major beauty, color and music enhancement, euphoria in combo with the DMT. DMT does not block serotonin but requires THH in combo to do this, important teamwork.
5-ht1a agonism is inhibitory and results in serotonin blockage (over 80% of brain 5-ht). Thomas S. Ray's study shows a value of 3.57 at SERT for Ibogaine (4.00 is max). Ibogaine has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine inhibits both serotonin and dopamine reuptake transporters, it is an SDRI or serotonin & dopamine reuptake inhibitor. THH or tetrahydroharmine also inhibits the serotonin reuptake transporter (SERT).
In contrast, as an example, Cocaethylene (coca leaf tea bags soaked in wine, the orally active & potent ingredient formed in the liver from cocaine + ethanol in the 1860's "Vin Mariani" wine popular with both Popes, Thomas Edison and scores of other famous people) increases the levels of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain by inhibiting the action of the serotonin transporter, norepinephrine transporter, and dopamine transporter. These pharmacological properties make cocaethylene a serotonin-norepinephrine-dopamine reuptake inhibitor [SNDRI; also known as a "triple reuptake inhibitor"].
Dr. Narang:
https://innovareacademics.in/journal/ijpps/Vol3Suppl2/1092.pdf
The absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Sublingual mucosa under tongue is only 100 to 200 microns thick.
Sublingual administration from wikipedia:
https://en.wikipedia.org/wiki/Sublingual_administration
This route translates the chemical directly to the brain, where most psychoactives act. When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation.[1] In contrast, substances absorbed in the intestines are subject to first-pass metabolism in the liver before entering the general circulation.
Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, by either stomach acid or bile, or by enzymes such as monoamine oxidase (MAO). Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines, the oral route is unsuitable for certain substances, such as salvinorin A.
MESO-Rx, "Ask Patrick Arnold #10", April 15, 1999 By Chemist & bodybuilder Patrick Arnold:
Sublingual hydroxypropylbetacyclodextrin (HPBCD) complexed testosterone has a very high bioavailabilty however as the peak blood levels are seen rather quickly (20 to 40 minutes). These peaks are quite high however and the drop off is substantially gradual as in the EMU study testosterone levels of greater than 60% over baseline were still measured after 2 hours.
Straight testosterone or prohormones do not have very good absorption under the tongue. When complexed with cyclodextrin the properties change to enable it to absorb extremely well. It would be a long and detailed explanation but that is the jist of it.
DMT is very similar to pro-hormones, poor absorption under tongue, but when complexed to HPBCD, it absorb's extremely well, studies show up to 400% increased penetration. Chemist Patrick Arnold taught me how to complex pro-hormones in my 20's:
https://thinksteroid...rick-arnold-11/
Patrick Arnold's latest project:
https://www.news-gaz...60a6be31c8.html
Does ayahuasca produce tolerance?
https://thethirdwave...lics/ayahuasca/
Ayahuasca tolerance is very mild and you can take another dose within a day without significantly reduced effects. It also does not produce tolerance to other psychedelics.
To test this, after 3 hours of tripping hard during afternoon on 200mg oral harmine + 200mg oral THH + 120mg sublingual HPBCD DMT dosed at 1 hour after oral harmalas, then again more sublingual HPBCD DMT at 1.5 hour later...I then took 3 hits of LSD at night, and tripped the rest of the night as if I had not taken anything during the day. The LSD had lost nothing in potency! This statement is true from thethirdwave.
Music lovers will love Sublingual DMT with oral harmine + THH, other worldly music enhancement, every sound in the music is literally "epic". Like hearing any track for the very first time.
https://jaytechmusic.podbean.com/
https://www.friskyradio.com/
https://soundcloud.com/
Pic 1: sublingual mucosa under tongue only 100 to 200 microns thick:
https://innovareacad...Suppl2/1092.pdf
Pic 2: upper top: 200mg of THH freebase to take orally, 200mg of harmine freebase to take orally, 120mg of DMT to complex to the x7 or 840mg HPBCD with 10 drops of hot water added from a pipette, keep a microwaved coffee mug nearby to add the boiling hot water drops.
Pic 3: capsules containing 200mg harmine + 200mg THH or tetrahydroharmine to take orally around 1 hour before using the sublingual. On spoon: 120mg DMT freebase complexed to x 7 or 840mg HPBCD in 10 drops hot water on a spoon using the end of another spoon to mix and crush it all together. Then place bottom side of tongue onto spoon, the psychedelic complex will all adhere as HPBCD forms sticky complexes that improve absorption of the DMT into the sublingual mucosa under tongue by a whopping 400%. There is a mild menthol-like sting but it is so worth the 10 to 15 minute sublingual absorb wait time depending on DMT dosage. Note: If using 120 to 150mg DMT, use 12 drops of boiling hot water to complex to the HPBCD.
Pic 4: 1:1 molar ratio of HPBCD to DMT is used
Pic 5: The HPBCD tornado like cone complexes to the DMT making it not only water soluble but absorbs 400% better into the sublingual mucosa under tongue, DMT salts do not work when applied under tongue.
Pic 6: The HPBCD DMT complex can be stored forever by removing the plunger from a 3ml syringe (100 of these 3ml syringes with storage caps can be ordered for less than $12) and backfilling or pouring the contents from the spoon into the syringe, then replacing plunger, then freeze in freezer, will keep indefinately, when ready to use, simply remove syringe from freezer, dunk into a cup of warm water with the cap still on the syringe bottom, it will defrost in 30 seconds, then remove cap and shoot contents directly under tongue, super easy to use or re-dose at any time during the night so you don't have to stop to make it.
Pic 7: Serpents are the manifest Spirit of Ayahuasca, many times I have viewed feminine spirit teaching Serpents during my sublingual Ayahausca journeys:
https://earthmedicin...erpent-of-eden/
Pic 8: Notice the force with which DMT hits 20% of the brain receptors in this receptorome or radioligand chart, also note it does not block serotonin or agonize the 80% of 5-ht1a receptors which cause serotonin blocking (inhibitory) when agonized but requires THH or tetrahydroharmine to do this, important teamwork.
cause I can't stay up to watch movies.
