Study says MPH is neurotoxic, too!

[glab]

That's kinda worrying. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033693

 

[d1nach]

10 mg per kg is enormous im 220 pounds or 100 kilos so thats like a gram a day youd die before gou notice long term damage to your brain .

 

[glab]

But they also say that therapeutic doses may also be damaging.

 

[d1nach]

According to them injecting 5 mg per kg in a rat is representive of a typical theraputic dose ? Atless rats have some bizzare metabolism ivdont see how thats remotely close. And, they only had a small but statistically significant effect at 10 mg per kg. If you are using it in theraputic doses i dont think because injecting the intenstinal track with 10 mg kg of methylphenidate has a higher probability then chance of causing a slight increase in oxidative stress of the basal ganglia which may cause parkinsons despite the cause of parkinsons being unknown is cause for concern just further research. I could publish a paper on how water causes brain oxidation when injected at high amounts

 

[d1nach]

Plus, when you look at there chart they knly show statistical significance in the highest dose group and only in the 1 mg per kg when they add mptp a actual toxin. I think a key sentence that describes their motives is "methylphenidate causes elevations of dopamine which is problematic." All they did was crank the doses to crazy amounts until they found something.