Cool. It's really neat how psychedelics have unveiled so much about how the brain works historically (ie I believe LSD led to the understanding of there being receptor sites at all, or at least the existence of serotonin sites), and continue to do so. I wish I understood the implications of this better though. Can anyone explain this "toggle switch" they're talking about?
Is it like this: there's some kind of toggle switch within the receptor site that is either activated or not, and that agonists that bind to the site are activating the "switch" or displacing the tryptophan that's sitting in there, and causing the neuron to be excited, whereas a non-agonizing chemical that binds to the receptor site without activating that switch? Am I on the right track?