Opioids Short acting opiate reset drug

[Synaps3]

So I've been a daily kratom user for 3 years and I am very happy that the kratom tolerance eventually stops decreasing. It plateaus, so I found that eventually I didn't have to keep using more. Well, then I started using 2map for a month and now it's not very good. After about a week without 2map, the kratom started working OK, but it's still not quite as good.

I was wondering, does anyone know of a substance or supplement that reduces opiate tolerance that is short acting. What I would plan to do is go back to my kratom dosing (which is twice a day - morning and night) and then take this stuff in between doses to reset the tolerance a little each time. So it's got to be something shorter acting (like 4 hours would be good). IDK if naltrexone lasts too long? All I have heard about so far is naltrexone and agmatine. Any other ones?

Also if anyone knows about anything that gets rid of opiate tolerance going back up quickly (hysteresis maybe)? When I say that, I mean the tolerance that shoots back up in a few days. Clearly the brain is able to reset, but it has something else that's not resetting the receptors. Is there any research into this?

Thanks.

 

[nznity]

Ketamine.

 

[Nicocastillo7]

Ketamine

This ^^
Ketamine appears to decrease tolerance to opiates. It is very interesting how ketamine works. You can search the internet for some studies on this, I can't recommend that you use ketamine anyway.
edit:
Some interesting studies

Experience of the use of Ketamine to manage opioid withdrawal in an addicted woman: a case report

Opioids are good painkillers, but many patients treated with opioids as painkillers developed a secondary addiction. These patients need to stop misusing opioids, but the mild-to-severe clinical symptoms associated with opioid withdrawal risk increasing ...

www.ncbi.nlm.nih.gov

Ketamine Attenuates and Reverses Morphine Tolerance in Rodents

Background. The development of tolerance complicates the use of morphine to manage persistent pain. N-methyl-D-aspartate receptor antagonists can attenuate or reverse morphine tolerance. The authors studied ketamine's ability to modulate morphine tolerance.Method. Tolerance was produced in mice...

anesthesiology.pubs.asahq.org

Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol

Review question/objective: The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-b...

www.nursingcenter.com

 

[nznity]

This ^^
Ketamine appears to decrease tolerance to opiates. It is very interesting how ketamine works. You can search the internet for some studies on this, I can't recommend that you use ketamine anyway.
edit:
Some interesting studies

Experience of the use of Ketamine to manage opioid withdrawal in an addicted woman: a case report

Opioids are good painkillers, but many patients treated with opioids as painkillers developed a secondary addiction. These patients need to stop misusing opioids, but the mild-to-severe clinical symptoms associated with opioid withdrawal risk increasing ...

www.ncbi.nlm.nih.gov

Ketamine Attenuates and Reverses Morphine Tolerance in Rodents

Background. The development of tolerance complicates the use of morphine to manage persistent pain. N-methyl-D-aspartate receptor antagonists can attenuate or reverse morphine tolerance. The authors studied ketamine's ability to modulate morphine tolerance.Method. Tolerance was produced in mice...

anesthesiology.pubs.asahq.org

Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol

Review question/objective: The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-b...

www.nursingcenter.com

Now i want some morphine xD

 

[negrogesic]

Black seed oil helps reduce tolerance, and works particularly well for reducing kratom tolerance.

Google Scholar

scholar.google.com

 

[falsifiedhypothesi]

Black seed oil helps reduce tolerance, and works particularly well for reducing kratom tolerance.

Google Scholar

scholar.google.com

Have you tried this yourself? I get jack shit out of kratom anymore

 

[Snafu in the Void]

Black seed oil helps reduce tolerance, and works particularly well for reducing kratom tolerance.

Google Scholar

scholar.google.com

Have you tried this yourself? I get jack shit out of kratom anymore

I tried this a few years ago. Didn't really do much... then again the buzz from kratom is so slight especially with tolerance its hard to even tell.

I tried everything to lower kratom tolerance. Nothing helped except significantly lowering my intake or taking a few days off.

 

[Synaps3]

So does ketamine or black seed work if you don't take it WITH the kratom? Cause I'm not looking for something that just boost the effects, but rather something that is actually lowering my tolerance.

 

[negrogesic]

Have you tried this yourself? I get jack shit out of kratom anymore

Yeah the potentiation is unmistakable. You can even clearly feel black seed oil on its own. Most useful for kratom, less so with other opioids. Its a drug on in its own right. It works indirectly on the opioid system via its ion channel blocking properties. This is particularly relevant with kratom as it is a calcium channel blocker as well. It reduces the kratom withdrawal restlessness significantly.