slimvictor
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Researchers unveiled a breakthrough imaging technique Thursday that show what blood flow in the brain looks like on cocaine.
For the first time, researchers have been able to prove “cocaine induced microischemia,” a precursor to stroke that arises when blood flow shuts down. The experiment was conducted on mice via cocaine injections. The results were published in the journal Biomedical Optics Express.
The method means that we can finally see tiny vessels called capillaries, which form the brain’s circulation network.
The new technique grew out of optical coherence Doppler tomography, or ODT, which previously revolutionized imaging for the eyes. Originating in the early 1990s, ODT works by hitting moving blood cells with lasers and then measuring the frequency of the light that bounces back. It essentially quantifies blood flow through recording speed and volume.
The methodology was developed by biomedical Engineers at Stony Brook University and the National Institutes of Health. According to co-author of the report Yingtian Pan, ODT now incorporates “a new processing method called phase summation” that makes the equipment able to detect very low blood speeds and visualize capillaries.
cont at
http://www.pbs.org/newshour/rundown/brains-blood-cocaine/
Article they cite: http://www.osa.org/en-us/about_osa/.../this_is_your_brain_s_blood_vessels_on_drugs/
Original Scientific article:http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-5-9-3217
Abstract
Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold; in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular/arteriolar flows. ODT was able to identify cocaine-elicited microischemia and quantify CBFv disruption in branch vessels and capillaries that otherwise would have not been possible.
For the first time, researchers have been able to prove “cocaine induced microischemia,” a precursor to stroke that arises when blood flow shuts down. The experiment was conducted on mice via cocaine injections. The results were published in the journal Biomedical Optics Express.
The method means that we can finally see tiny vessels called capillaries, which form the brain’s circulation network.
The new technique grew out of optical coherence Doppler tomography, or ODT, which previously revolutionized imaging for the eyes. Originating in the early 1990s, ODT works by hitting moving blood cells with lasers and then measuring the frequency of the light that bounces back. It essentially quantifies blood flow through recording speed and volume.
The methodology was developed by biomedical Engineers at Stony Brook University and the National Institutes of Health. According to co-author of the report Yingtian Pan, ODT now incorporates “a new processing method called phase summation” that makes the equipment able to detect very low blood speeds and visualize capillaries.
cont at
http://www.pbs.org/newshour/rundown/brains-blood-cocaine/
Article they cite: http://www.osa.org/en-us/about_osa/.../this_is_your_brain_s_blood_vessels_on_drugs/
Original Scientific article:http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-5-9-3217
Abstract
Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold; in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular/arteriolar flows. ODT was able to identify cocaine-elicited microischemia and quantify CBFv disruption in branch vessels and capillaries that otherwise would have not been possible.
