floopysnow
Greenlighter
- Joined
- Jan 23, 2020
- Messages
- 2
An experiment into rectal administration of diazapam
I have included my own trip report, but for the adventurous you may consider the following as a guide on how to do it yourself, although please adjust the dose to fit your tolerance/experience.
I have wanted to try both volumetric dosing and rectal administration of diazapam for quite some time as I have heard through various sources that despite diazapam already has a good bioavailibility, it does in fact have a higher rectal bioavailibility, as well as a much faster onset of action, and decided to conduct an experiment of my own, as there seems to limited information on the use of rectal diazapam. The few of posts I found on bluelight and /r/drugs were not particularly informative.
For volumetric dosing where you intend on using the oral route of administration, I must recommend using propylene glycol, as diazapam's solubility is almost three times than with vodka. I have not done any tests on rectal administration of propylene glycol/diazapam, but I plan to experiment with this further in the future.
15ml ethanol dissolves 1000mg of diazapam (Source: HSDB)
Vodka is typically 37.5-40% ethanol
1ml of vodka contains 0.375-0.400ml
1ml of vodka can dissolve 23.8-26.7mg of diazapam
I planned to take 80mg rectally - I wanna say now that I have naturally high tolerance, and I've been taking about 20-30mg each day for the last week or two, so I do not recommend this as a normal test dose to anyone. I wanted the effects of the test dose to be strong enough so that I could notice and document each effect as they manifested. Sources are at the bottom of the report. If anyone else is considering attempting what is written here, please adjust the dosage to fit your tolerance and be careful - better safe than sorry. To a first timer I would recommend 10-20mg maximum.
THE TEST
[T-00:10] For my test dose I needed at least 3.36ml of vodka to dissolve 80 mg, I dissolved 80mg of diazapam in little blue tablet form, '10mg' a tablet, in 4ml of vodka just to be sure. I would be using 2ml rather thin oral syringes
[T-00:00] Time of dosing: about 22:00
I set up my patch on the floor to begin the experiment, with a pillow for company I lay on my side and lift my leg slightly to make it easier to insert the syringe. Once in almost as far as it could go (syringe roughly 2-3 inches in length), I pushed down on the plunger quickly, which was immediately proceeded by a mild burning sensation up my abdomen which indicated a successful dosing and that the vodka/diazapam solution has been dispersed along rectum and sigmoid colon. The syringe was then washed and this step was then repeated for the remaining 2ml of vodka solution.
[T+00:02] I would continue to lay on my side and then my front as I gave the vodka/diazapam solution time to absorb, and could already begin to feel a heaviness and calmness starting to spread throughout my body, seemingly originating from my abdomen which was still burning slightly, though fading slowly. I also used this time to pour a small amount of cider into the shot glass I had used to mix the vodka and diazapam pills where there was still some residue blue sludge, which I drank down with the cider (let none go to waste!)
[T+00:05] The previously stated feelings continued to build in intensity during this time. After five minutes, the mild burning in my abdomen was completely gone and I felt comfortable enough about not 'spilling' to stand up and make my way to the bath room.
Immediately I noticed drastic decrease in motor control, my mind was blissfully blank, and not subjected at all to my usual anxiety-induced thought loops and feeling of impending doom. I got to the bathroom to clean up and was pleased to see no blue residue on my toilet paper, meaning I hadn't 'lost' any (the vodka/diazapam solution had been made with these little blue 10mg pills, and so the resulting solution was pretty blue).
[T+00:30] At this point I am in divine comfort, I feel as if was peaking on at least 4-5mg of Xanax, but with that beautiful diazapam muscle relaxation. I'm just sitting here in pure contentedness, playing Killing Floor for some shits and giggles, and it was actual a blast - I used to play invite sniper/scout for TF2, so I am pretty good with FPSs - time felt slightly slowed and I felt like I was hitting more headshots due to my patience in aiming.
[T+01:30] I now just feel like I normally would if I have just taken the diazapam dose normally, but with the added feeling of having had a couple of drinks on top.
I completely forget to take my antidepressant/sleep aid 15mg Mirtazapine that night, not that I needed it.
[T+11:00] The next day at 9:00, which is early for me, I wake up still feeling relaxed and content, and feeling more refreshed than usual! I go and make myself a coffee. I feel content and non-anxious for most the day. I would normally take a 10mg diazapam tablet when I wake up, but I didn't feel the need this time, and ended up only using a half tablet, 5mg around 22:00 as I heard of some news that was difficult to cope with, and then about an hour later I took my usual 15mg Mirtazapine before getting into bed
SUMMARY / TL|DR
Rectal administration of diazapam in a vodka solution (for all intents and purposes: 37.5-40.0% ethanol with the remaining water) provided a significantly faster onset than orally administered diazapam with minimal discomfort and had a length of duration the same as orally administered diazapam.
Also anyone who is worried about boofing alcohol, in the volumes used there is no risk of overdosing on 2ml or 4ml of vodka! (Other than it might dry out your butt a bit... although I experienced minimal discomfort).
(Source: HSDB) https://pubchem.ncbi.nlm.nih.gov/compound/Diazepam#section=Solubility
I have included my own trip report, but for the adventurous you may consider the following as a guide on how to do it yourself, although please adjust the dose to fit your tolerance/experience.
I have wanted to try both volumetric dosing and rectal administration of diazapam for quite some time as I have heard through various sources that despite diazapam already has a good bioavailibility, it does in fact have a higher rectal bioavailibility, as well as a much faster onset of action, and decided to conduct an experiment of my own, as there seems to limited information on the use of rectal diazapam. The few of posts I found on bluelight and /r/drugs were not particularly informative.
For volumetric dosing where you intend on using the oral route of administration, I must recommend using propylene glycol, as diazapam's solubility is almost three times than with vodka. I have not done any tests on rectal administration of propylene glycol/diazapam, but I plan to experiment with this further in the future.
15ml ethanol dissolves 1000mg of diazapam (Source: HSDB)
Vodka is typically 37.5-40% ethanol
1ml of vodka contains 0.375-0.400ml
1ml of vodka can dissolve 23.8-26.7mg of diazapam
I planned to take 80mg rectally - I wanna say now that I have naturally high tolerance, and I've been taking about 20-30mg each day for the last week or two, so I do not recommend this as a normal test dose to anyone. I wanted the effects of the test dose to be strong enough so that I could notice and document each effect as they manifested. Sources are at the bottom of the report. If anyone else is considering attempting what is written here, please adjust the dosage to fit your tolerance and be careful - better safe than sorry. To a first timer I would recommend 10-20mg maximum.
THE TEST
[T-00:10] For my test dose I needed at least 3.36ml of vodka to dissolve 80 mg, I dissolved 80mg of diazapam in little blue tablet form, '10mg' a tablet, in 4ml of vodka just to be sure. I would be using 2ml rather thin oral syringes
[T-00:00] Time of dosing: about 22:00
I set up my patch on the floor to begin the experiment, with a pillow for company I lay on my side and lift my leg slightly to make it easier to insert the syringe. Once in almost as far as it could go (syringe roughly 2-3 inches in length), I pushed down on the plunger quickly, which was immediately proceeded by a mild burning sensation up my abdomen which indicated a successful dosing and that the vodka/diazapam solution has been dispersed along rectum and sigmoid colon. The syringe was then washed and this step was then repeated for the remaining 2ml of vodka solution.
[T+00:02] I would continue to lay on my side and then my front as I gave the vodka/diazapam solution time to absorb, and could already begin to feel a heaviness and calmness starting to spread throughout my body, seemingly originating from my abdomen which was still burning slightly, though fading slowly. I also used this time to pour a small amount of cider into the shot glass I had used to mix the vodka and diazapam pills where there was still some residue blue sludge, which I drank down with the cider (let none go to waste!)
[T+00:05] The previously stated feelings continued to build in intensity during this time. After five minutes, the mild burning in my abdomen was completely gone and I felt comfortable enough about not 'spilling' to stand up and make my way to the bath room.
Immediately I noticed drastic decrease in motor control, my mind was blissfully blank, and not subjected at all to my usual anxiety-induced thought loops and feeling of impending doom. I got to the bathroom to clean up and was pleased to see no blue residue on my toilet paper, meaning I hadn't 'lost' any (the vodka/diazapam solution had been made with these little blue 10mg pills, and so the resulting solution was pretty blue).
[T+00:30] At this point I am in divine comfort, I feel as if was peaking on at least 4-5mg of Xanax, but with that beautiful diazapam muscle relaxation. I'm just sitting here in pure contentedness, playing Killing Floor for some shits and giggles, and it was actual a blast - I used to play invite sniper/scout for TF2, so I am pretty good with FPSs - time felt slightly slowed and I felt like I was hitting more headshots due to my patience in aiming.
[T+01:30] I now just feel like I normally would if I have just taken the diazapam dose normally, but with the added feeling of having had a couple of drinks on top.
I completely forget to take my antidepressant/sleep aid 15mg Mirtazapine that night, not that I needed it.
[T+11:00] The next day at 9:00, which is early for me, I wake up still feeling relaxed and content, and feeling more refreshed than usual! I go and make myself a coffee. I feel content and non-anxious for most the day. I would normally take a 10mg diazapam tablet when I wake up, but I didn't feel the need this time, and ended up only using a half tablet, 5mg around 22:00 as I heard of some news that was difficult to cope with, and then about an hour later I took my usual 15mg Mirtazapine before getting into bed
SUMMARY / TL|DR
Rectal administration of diazapam in a vodka solution (for all intents and purposes: 37.5-40.0% ethanol with the remaining water) provided a significantly faster onset than orally administered diazapam with minimal discomfort and had a length of duration the same as orally administered diazapam.
Also anyone who is worried about boofing alcohol, in the volumes used there is no risk of overdosing on 2ml or 4ml of vodka! (Other than it might dry out your butt a bit... although I experienced minimal discomfort).
(Source: HSDB) https://pubchem.ncbi.nlm.nih.gov/compound/Diazepam#section=Solubility
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