Has anyone come across a method to racemize the title compound? I have noted that the (S) isomers of phenylaminpentane, diphenidine & ephenidine are vastly more active. Besides doubling the potency, the ADME cycle will be significantly changed. Now, as I have said, isophenidine is by far the most K-like and it's water-soluble so you can snort it (the sulfate salt of diphenidine is also water soluble but the cretins who scaled this one found different addition salts far, far too much like hard work. But as pure (D) meth has a much bigger kick than the racemate, I suspect that (S) isophenidine will be MUCH more like K.
I should add that isophenidine didn't get made because the same idiots were removing H2O from the reaction thermally. Now, I accept that TiCl4 isn't fun BUT I found a lovely route that used isopropyl amine with KOH removing the H2O but guess what? Even that was beyond them.
So, any thoughts?
I should add that isophenidine didn't get made because the same idiots were removing H2O from the reaction thermally. Now, I accept that TiCl4 isn't fun BUT I found a lovely route that used isopropyl amine with KOH removing the H2O but guess what? Even that was beyond them.
So, any thoughts?