Opioids Question on opioid/opiate tolerance

[Insect Calm]

Hi! This is my first post and thread here. Been lurking for a while, but registered now since I couldn't find any answer from googling. Please be nice, couldn't find an appropriate thread to post in so made my own.

I'm not a hugely experienced user when it comes to opioids, I buy a small amount of opioids maybe two times each year (have tried both weaker substances such as codeine, ethyl-morphine and such as well as stronger ones like oxycodone). I like the typical opioid high and have always gotten relatively mild side effects, but for some reason I seem to have an extraordinary tolerance to them.

I recently did 40mg of oxycodone (first time i've taken any opioid for about a year) and the effects werent that powerful, even though I mixed with 0.45mg of flunitrazepam. I've taken rather heavy doses for someone with no tolerance who uses them very seldom and sporadically without getting very strong effects. Only a few times have I gotten strong effects, but have you guys any idea why this might be? For example I don't buy tramadol because the doses I need to get even moderatly high have felt dangerously close to cramping doses (around 500mg+). I've never read about anyone who naturally has such a high tolerance, so i'm curious about your thoughts on the matter.

Since I'm not very experienced with opioids I usually take small doses in intervals and try to work my way up to a pleasurable high, rather like with dissociatives. This is the only reason I can think of, but I don't wait very long between refills if I don't get a strong effect so the concentration should still add up to almost the same as if taken all at once or have I missed something here?
I can also add that I'm a not very heavy (about 65kg and 183cm in length) and haven't got a ''naturally'' high tolerance to any other substances except alcohol (which is because that's what I consume the most).

 

[Keif' Richards]

Hey man, as far as people with innate tolerances to Opioids, I am one such person. I can easily consume 200mg Oxycodone in a sitting. I've done it many times, as I've lived in areas with laissez-faire attitudes towards pharmacy control. It can have to do greatly with an individual's enzyme activity. For instance, Codeine has nil effect upon me. If I take several grams, it can be enough to arrest severe withdrawal symptoms, but that's it. Oxycodone, being a bit stronger, still has little effect upon me.

Morphine and the -Morphones effect me in a more predictable way, although I still have a higher than normal tolerance to them.

Have you experienced positive effects from Oxycodone in the past? You might just need to reach for something different.

 

[jamesBrown]

Natural tolerance. People with natural tolerance to opioids tend to be more likely to become addicted.

I am one of those people.

The VERY FIRST TIME I ever took any opioid was for mild overall body pains from years of athletic activity and related injuries. The drug was hydrocodone. I had heard about my fellow schoolmates and athletes taking hydrocodone for their pains so they could play a game with sprained ankles(I thought they were crazy) so I figured I would give it a try. I needed around 7-8 10mg Vicodin(70-80mgs) to get any pain relief....and at least 100mgs to feel any "good/euphoric" feelings. I found this odd because everyone else was only taking 5-20 mgs for pain relief or even to get high.

That intrigued me, so I did some research and came to the conclusion that I must have been born with a naturally high tolerance. I soon learned that my tolerance applied to ALL opiod medications/drugs....so it wasn't just a weird thing with me and hydrocodone alone.

It didn't take long for me to become dependent...then addicted...then I found myself reaching for the needle. So fast. So if someone thinks they have a natural tolerance...beware.

 

[MDPV_Psychosis]

I'm not sure why people with a natural high tolerance would be more prone to addiction? I think human beings, in general, are often just prone to addiction regardless of their natural tolerance level.

I quickly became addicted and I had a very low natural tolerance to begin with. I remember 5mg of Vicodin completely rocking my world the first time I tried it.