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Psychedelics and Prozac

ros18167

Greenlighter
Joined
Nov 30, 2015
Messages
17
Does Prozac (and other SSRIs) interfere with the action of psychedelics? My friend took 200ug of acid, 50mg of 4aco and 50mg of 2cb but wasn't tripping.

Thanks
 
SSRIs typically dampen the effects of psychedelics, and Fluoxetine also has some activity as a 5HT2C antagonist (so it might potentially block psychedelics at that receptor subtype, although I'm not sure how high its binding affinity actually is)... still, 200µg of acid should have gotten you tripping unless you have serious tolerance or you were taking other drugs that antagonize serotonin receptors.
 
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