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This is by no means the simplest nor the cheapest ketamine/methoxetamine analogue but I've put up the Roche patents on the 2-chloro-5-methoxy substitution being twice the potency of the m-methoxy (MXE) ring substitution and thus about seven times the potency of ketamine. The thianes are much more active than their cyclohexane counterparts and N-ethyl proves to give an appropriate balance of NMDA and dopamine activity. BUT given that the NMDA activity will be higher, maybe the N-methyl would be more appropriate. The N-isopropyl is also interesting (it was the most potent monosubstitution when PCP analogues were investigated) so that would also be worth looking at...
But it's a solid but novel design and given that K sells for £50/g, something that's x7 more potent would, I presume, fetch seven times the price IF it were sold as K. Goodness knows what one would choose to cut it with and I hate the idea of cutting a perfectly good drug but it seems that people prefer to pay £50/gram for a nice white powder than £350 or to pay £50 for 140mg. MAYBE £30 a point... but buyers seem to be at home with round numbers for round amounts.
Also, given the way things are going, their will be someone issuing a patent for α-Methyl sufentanil. From patent data, it would appear that the racemate is about x15 fentanyl i.e. x1200 M. BUT the key things are that it's TI is truly huge (>12000), it's duration is 4-6 hours, it's orally active and it's amenable to sustained release formulations (so one pill ever 12 or 24 hours) and to depot injections that would last for 28 days.
I also spent a few weeks looking at benzodiazepines. I found one that has a potency x10 that of flunitrazolam, a prodrug that would allow sustained release formulations (a pill every 12 or 24 hours) and once again, to depot injections that last 28 days. It's not some HUGE secret and most of it is known but nobody has put the ideas together, sadly/gladly.
If I had the money, I would patent the concepts and I feel certain that the drug research companies are JUST waking up to the fentanyl disaster and so in a year or two, they will wake up to the benzodiazepine disaster... but it will all be too late.
I COULD have samples made but that would be illegal and I don't 'do' illegal.