Stimulants physical tolerance

[Zonxx]

How long do you guys suppose built up physical tolerance to stimulants such as coke/ amphetamines lasts, as in the cardivascular tolerance etc if one were to suddenly stop using stims would tolerance rapidly drop or not so quick?

 

[CFC]

Cardiovascular tolerance rapidly drops yes. Maybe just a handful of days for a significant reset? Sadly there's not a lot of research on this.

 

[Nicomorphinist]

I would be inclined to think that 6-10 days may be a good starting point and may do the trick completely. My main experiences are with ephedrine, methylphenidate, and phenmetrazine at any great length and the tolerance build up was different for each drug. Since washing out tolerance essentially re-steepens the dose-response curve, potentiation with a chemically dissimilar stimulant can help to do the same thing afterwards so the tolerance slows down a bit next time.