Phenylethylamine (PEA) and MAO-A Inhibitor safety?

[Ventrusii]

I was considering getting some Phenylethylamine (PEA henceforth) and ran into some interesting problems/questions.

Since MAO-A inhibitors increase the potency of PEA-derivatives, wouldn't they also increase the potency of PEA itself, and because such, would a RIMA be okay to add to a stack with PEA, like a MAO-B inhibitor would be?

Would doing that increase the potency but not the length, or both? Or neither? Has anyone tried this?

 

[Slow_Mobius]

Yes maois are often used to potentiate PEA, but from what I've gathered, it's a fleeting, uncomfortable stimulant.

What is a RIMA btw?

 

[Ventrusii]

Reversable Inhibitor of Mono-amine oxidase A​

 

[Slow_Mobius]

Yes taking an MAO-A inhibitor should increase the potency of PEA and the MOA-B inhibitor would significantly increase its potency. I have no idea how safe it is to take both MAOIs with PEA, but I think it would be fine if you carefully manage your dosing... It'll certainly depend on your doses.

I'm sure people have done this before, so might look for reports with a Google search.

 

[d1nach]

I though phenylethylamine had such a short half life it wasnt a effective stimulant. Like minutes. Have you had different results?

 

[CmonYouShouldKnowBetter]

I though phenylethylamine had such a short half life it wasnt a effective stimulant. Like minutes. Have you had different results?

Taking it with an MAOb inhibitor should elongate the effects, no? Unless there are other enzymes that also work on PEA

 

[bluecollartweeker]

back when I was like 18 maybe 17, id mix about 1-2g of PEA with hordenine 30 minutes after strong cup cup of green tea, used to be my favorite. id get a euphoric tingly numb rush and lightheaded, thoughtless, spun rush. It took almost 3g with this method while chewing nicotine gum and vomited pretty bad once though. Literally the only rush or euphoric feelings I've had from any stimulant, even from shooing up phenmetrazines or snorting meth (I do have ADD so my experiences with stims are a bit weird) . but at that age I had only used caffeine and ephedrine I think.
I haven't been able to recreate that feeling with PEA in the present, and its not a useful stimulant and it was very short-lived, with diminishing returns. In my experience.

 

[CmonYouShouldKnowBetter]

back when I was like 18 maybe 17, id mix about 1-2g of PEA with hordenine 30 minutes after strong cup cup of green tea, used to be my favorite. id get a euphoric tingly numb rush and lightheaded, thoughtless, spun rush. It took almost 3g with this method while chewing nicotine gum and vomited pretty bad once though. Literally the only rush or euphoric feelings I've had from any stimulant, even from shooing up phenmetrazines or snorting meth (I do have ADD so my experiences with stims are a bit weird) . but at that age I had only used caffeine and ephedrine I think.
I haven't been able to recreate that feeling with PEA in the present, and its not a useful stimulant and it was very short-lived, with diminishing returns. In my experience.

I would venture to say that the hordenine would have helped elongate the effects by way of MAOb inhibition IF you had taken it like 25 minutes before the PEA

Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat - PubMed

The selectivity of the naturally occurring amine, N,N-dimethyltyramine (hordenine) for monoamine oxidase (MAO) and its action upon isolated vasa deferentia of the rat was investigated. Hordenine was deaminated by rat liver MAO with a Michaelis constant of 479 microM and maximum velocity of 128...

pubmed.ncbi.nlm.nih.gov