• N&PD Moderators: Skorpio | thegreenhand

  • Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

Pharming and Opiates

S

shadowhigh

Greenlighter
Joined
Jun 18, 2022
Messages
14
I'm currently on slow realise Morphine - 40mg in the morning, 40mg at night. I take it for chronic pain - Crohn's, Ehlers-Danlos, slipped desk, osteoporosis etc.

Would I get better pain relief if I switched to Dihydrocodine with an agonist like promethazine?
 
Is that basically just codeine and promethazine??? I think it'll just make you more sleepy tbh might not do more for pain because wat your on is much stronger
 
shadowhigh said:
I'm currently on slow realise Morphine - 40mg in the morning, 40mg at night. I take it for chronic pain - Crohn's, Ehlers-Danlos, slipped desk, osteoporosis etc.

Would I get better pain relief if I switched to Dihydrocodine with an agonist like promethazine?
Click to expand...
Ever try methodone?
 
I'll try to get the videos from my girlfriend, but there is a well known pain specialist who suggest things like duloxetine, gabapentin, I the NMDA antagonists like memantine (not saying that he suggest that drug, just that class similar to that drug) as medications that can help pain treatment.
 
WOAH!! lemme help here!!

No! You don't want to ask your doctor to switch you from morphine to DHC. Promethazine is simply an antihistamine and benadryl will accomplish the same task! and other guy NO DHC is not prometh and codeine; that is "lean". Dihydrocodeine is much better than codeine. Add prometh or benadryl as you wish; but stay safe!!

Morphine is the gold standard of opiates! Before even thinking of making such a request make sure you have looked at an opioid conversion chart so you know how much of whatever you ask for is equipotent to 80mg morphine daily....To be honest you should probably also try it for a week or so before even asking to switch; I had an aunt that switched from morphine to methadone and almost threw the methadones in the garbage they were so "different" and in her opinion inferior. And it does become pretty subjective. (id take the morphine myself)

40 mg twice a day extended release....do you mind me asking what shape and color they are? Most ER morphine can be made into instant release morphine simply by chewing the pill up. If so that is a good start.

duluxetine, gabapentin, memantine......well I am almost positive they throw those at people to avoid scripting opi's. They aint gunna cut it for pain, PERIOD.

If your current dose of medication is not covering your pain; if I were you; I would tell your doctor that you need either a higher dose or an additional instant release opi for "breakthrough pain".

I would look at opi's with similar potency to morphine but a higher oral bioavailability (percent that gets into your blood, with morphine oral it is around 33% whereas say oxycodone is somewhere near 80%.
That doesn't necessarily mean you want to switch to oxy though, think of them as flavors of ice cream; you may not appreciate the next one; or it may be your holy grail.
 
As said before. No don't do that, seems like step backwards.

Maybe add it in on top on the really bad days if you think your tolerance will be ok. It sounds like it might. Maybe just the prometh first. If you're in UK then DHC can be bought and easily washed off the paracetamol they insist on bashing it with.

But as earlier poster said if you meds aren't suiting your needs best speak to your doctor and seeking their advice.

But to answer your ultimate question, no I don't think you would get better relief.

Hope you find some better relief soon,

BB
 
Good deal. So like if you got cold water and the necessary funding (which gets to be alot id imagine) you are pretty much set for any bad days. Stateside closest we got is kratom, some would argue immodium; but not I. However ketamine and mdma therapy are now available. Mushrooms legal in a couple states and at least one with legal dmt.

Refresh my memory how many mg of DHC is decent buzz for; lets say a opi naive person? And how much do you get in an otc box. (don't worry im not going to the UK for otc dhc.....just interesting comparing situations in different places. Canada has OTC codeine w/ tyleol. India has a maximum price they are allowed to sell etizolam for stated on the box lol. Mexico seems to vary widely between how well you speak the language of the game. Haha my friend who went told me blow is 12 US dollars a gram in belize; though not legal.

Portugal it is legal to have 'small amounts' of any drug on you (I forget how they describe it exactly.
Did Mexico go back to there strange "handful" of any drug for personal law or did they fold and stay folded on that?
I think you can get some Opis OTC in france but im not positive, there was a real smart user here from there; idk if hes round here nemore
 
shadowhigh said:
I'm currently on slow realise Morphine - 40mg in the morning, 40mg at night. I take it for chronic pain - Crohn's, Ehlers-Danlos, slipped desk, osteoporosis etc.

Would I get better pain relief if I switched to Dihydrocodine with an agonist like promethazine?
Click to expand...
My pain is due to muscular tension, but I find that promethazine is useless combined with any opiate. Not much experience with DHC but morphine is stronger.
 
anterogradient said:
I'll try to get the videos from my girlfriend, but there is a well known pain specialist who suggest things like duloxetine, gabapentin, I the NMDA antagonists like memantine (not saying that he suggest that drug, just that class similar to that drug) as medications that can help pain treatment.
Click to expand...

Just want to throw out a little anecdote, my mother (and me and my brother of course, yay!) have Ehlers-Danlos. My mother does take duloxetine and gabapentin for her pain. The duloxetine might have worked a tiny bit early on, and the gabapentin seems to have a much more definitive effect on her pain, but there is tolerance with it. You're going to keep trying to escalate on the dose, but it's not actually going to make it much better after a certain point (research on gabapentin is out there that shows the ceiling dose on its therapeutic effects is way lower than the maximum daily dose). As long as you need constant pain management, rather than periodic help with pain, this is not going to cut it. I think this is especially true in this case since it seems they've got a lot more going on than just Ehlers-Danlos.

Maybe they could benefit from using these on top of the opiates, but not instead of them.
 
You must log in or register to reply here.
Top