Oh yeah, nasty bastards they are, the antipsychotics. I know some/many will disagree with me but I deeply hate them, even got repeated psychotic reactions to risperidone especially, also to chlorprothixene (Truxal, this one less a surprise as it's an anticholinergic) but the risperidone really got me wrong. I was in acute mental hospital care due to an accident (actually just wanted to have my vital signs monitored during the night as I feared to have overdosed on a weird RC, which wasn't the case and would have killed me if it was, as they did not monitor me but think I'd be psychotic, well.. I truly went psychotic after risperidone. Didn't know where I was, who I was, what time it was, and on top of all, I heard voices for the second time in my life. First one was on high dose DXM.)
Two years or so past, again in fucking mental care, they wanted to help me against recurring thoughts and similar stuff, by giving low dose antipsychotic - risperidone 1mg/d. Felt weird. When they upped it to 2mg/d, I began to hear voices in the noise of running water and ventilators, also became very irritable and uneasy when among other people - which you can't avoid in such a setting. Got into a dispute with my teen and pretty immature roommate because of which they threw me out. Best decision, the day after I've stopped the risperidone everything went back to normal.
Just a specific substance intolerance you might say? An unknown, low dose of haloperidol (yay, in parts of Germany it's still used as a first line tranquilizer) made me feel similarly weird, just w/o the voices. An hour or so passed when the cramps set in and I could barely breathe, so after heavy begging I got injected with akineton - made me euphoric and unable to sleep for more than 24h straight. Quetiapine 600mg/d made me panic and nearly collapse.
There are a few more incidences just as weird that I don't remember really anymore because they co-administered benzodiazepines to cover the reactions. Psych docs just don't believe that antipsychotics can be bad. Also I know of a bunch of other people with similarly strange reactions, also some which quality of life had been destroyed by docs forcing them to take antipsychs for years just as precaution for a single, isolated psychotic episode. Besides DXM I don't know of any recreational drug which is as weird by far. Oh, also I tolerate dopaminergics pretty well, even meth. I don't really like it but I tolerate it, it's got nothing psychotic at all.
Mirtazapine, while not a true antipsychotic by itself in that it doesn't share the heavy anti-dopaminergic (side) effects, but nevertheless it's got similarly weird qualities. It was one of the first meds I got, and I remember this strange side effect - you know, when a loud noise or something behind you scares you, and you get the shivers down your spine. Mirtazapine just inserted like a 1,5s delay between the shock and the shivers. Completely conscious, I knew what was going on, just the somatic reaction was delayed. Weird bunch of shit.
But what destroyed my ability to trip was venlafaxine (effexor). I've been on that for most of my adult life, even now I struggle to quit. Brain zaps and dysphoria without end, think I managed it through 3 weeks or so for the longest. They shouldn't say it might make teenies suicidal, but a straight no-go for anyone below 22 years or so. When given while the brain's still developing, it builds a hefty and pretty irreversible tolerance.
Disassocitives help, maybe due to their release of brain growth factor, activation of mTOR or whatever, but unfortunately only for so and so long, usually a few days (span has been longer earlier, when I still got week-long afterglows from that dirty chick of DXM.. nowadays I don't tolerate it anymore, makes me psychotic too. Ket & co aren't a problem at all.)