Parnate ( Tranylcypromine)

[Davevanza]

Hi,

I've been taking all sorts of antidepressants, antipsychotics, Mood stabilizers, antianxiety medications since 1994.

Back then in the early 1990's, SSRIs'/ SNRIs were still not in the market here in Australia.

So my Psychiatrist prescribed me with :

-Imipramine ( just took 10mg twice daily, good for Panic disorder maintenance, but, somehow, i just could not tolerate with its side effects)

- Desipramine ( this is an active metabolite of Imipramine actually, with the advantage, that it causes less sedation and anticholinergic effect. But, I couldn't tolerate it, as it made me feel jittery, agitated, and more anxious.)

- Amitriptyline ( Good for sleep, as i am an insomniac. But again, its side effects stopped me from using it further.)

- Nortriptyline ( actually, an active metabolite of Amitriptyline, with less anticholinergic effect.)

BUT BOTH Desipramine and Nortriptyline acts mainly on Noradrenaline.
So unlike their parent drugs, which affects the 3 Neurotransmitters ( Serotonin, Noradrenaline, Dopamine)


- Moclobemide ( it is a MAOI, but type A, meaning that it prevents the oxidation of the 3 Neurotransmitters, and if it's used within the recommended dose, 600mg or below, no dietary restrictions are required. But, it just didn't work for me, the effect is mild, neither sedating nor stimulating, only a bit of restlesness at the first week. It didn't work for my Anxiety, Panic, and Depression problems)


As the SSRIs ( Fluoxetine, Paroxetine, etc), SNRIs ( Venlafaxine, Duloxetine, Milnacipran), and other Antidepressants such as NaSSA ( Mirtazapine, it actually is, 6-aza-Mianserin, an old novel Antidepressants with sedating properties), and others like Atypical Antidepressants/Atypical antipsychotics/Mood stabilisers ( like Neurontin, Pregabalin, Valproate, etc), my Psychiatrist tried me on them , to see which one is suitable for me.



Right now,
I am on :

- Mirtazapine 90mg nocte ( nite)
-Clonazepam 2mg daily
- Tramadol SR occassionally for headache.


The last session i talked to my psychiatrist, I complained about feeling of Lethargy on the next morning after taking Mirtazapine. I also sleep up to 16 hours, during weekend while on it.


So , my Doc, kept in his mind, about the last resort of medication to use.

It is PARNATE ( Tranylcypromine).



My questions are :

1.Has anyone ever taken this?

2. Does it give insomnia?

3. Is it worth to sacrifice food that I like, while on Parnate?

4. If anyone is on it at the present time, do eating out for Dinner as for socialisation, REALLY INCREASE your blood pressure due to the Tyramine?

5. I have done the research, that, somehow, its effect is like amphetamine.
But, my Doc is reluctant to give Ritalin 10mg ( 30 tabs) /Dexamphetamine 5mg (100 tabs) which only costs around $ 20 or below, compared to Modafinil here, which costs around $ 100 for 30 tabs.

Any input is greatly appreciated.

kind regards,
Dave


Any input is greatly appreciated.

Kind Regards,
David

 

[Davevanza]

My Doc is reluctant to give any stimulants such as Ritalin, Dexamphetamine etc

But, he is happy to prescribe me, Parnate.

Parnate's effect, is almost similar to amphetamine, except Parnate is a MAOI.

Anyone ever been on this?

I am so curious, wanting to try its effect, but scared of the hypertensive crisis from the food with high Tyramine.



Anyone has any suggestion?

 

[Mr Blonde]

In case you weren't already aware, tranylcypromine is non-selective irreversible MAO inhibitor so dietary and medication restrictions will apply. It is quite an old anti-depressant, I doubt many here have been on it.

Here is a list of adverse effects from MedScape:

Adverse Effects
Frequency Not Defined
Orthostatic hypotension

Dizziness

Headache

Drowsiness

Sleep disturbance

Fatigue

Weakness

Tremor

Hyperreflexia

Constipation

Dry mouth

Confusion

Decr memory

Nystagmus

Paresthesia

Anorexia

N/V

Impotence

Urinary frequency or retention

Anxiety

Irritation

Hypomania

"Hypermetabolic syndrome" (hyperpyrexia, tachycardia, tachypnea, incr CPK, acidosis)

Arthralgia

Edema

SIADH (rare)

Risk of hypertensive crisis (rare,usu d/t drug interaction)

Ataxia (rare)

Seizure (rare)

Jaundice (rare)

Visual disturbance (rare)

 

[perKeceT]

this drug sounds a bit sketchy. if it works for what you need it for though than good. im from the USA and havent ever heard of this drug.
off topic: what is it with austrailian doctors not wanting to prescribe real drugs that work (like amp/MPH in this post)?
EDIT: just saw the wiki page for this, so its actually a substituted PEA? actually kinda interesting...

 

[DeathDomokun]

I'm just gonna copy this from another post I made
Now MAOI's, first off there are reversible maoi's and irreversible maoi's. Shit like tobacco and harmaline, the shit syrian rue for example is reversible; basically this means that most of the dietary restrictions involved with maoi's and what not don't matter as much. Just thought I'd mention that because thats a huge myth around taking harmaline to potentiate psychedelics, that "if you have a beer or eat Parmesan cheese YOU WILL DIE". If you're on an maoi for depression purposes or anxiety, I'm pretty sure a majority of them are irreversible, so make sure you learn what you can and cannot take food and drug wise.
The idea here is different to SSRI's. The idea is that depression is related to Serotonin, but instead of leaving it in the synaptic gap and preventing it from going back into our old friend A the axon, it prevents the things that break it down. Monoamine oxidase is what nerds call MAO. This is the mother fucker that destroys the left overs in there when that serotonin (and others! dopamine and a bunch ofthers!) are in that synaptic gap.
Theres MAO-A and MAO-B, iirc MAO-A is the cool, important one generally, in terms of 'feeling happy' because that one deals with Serotonin and a most others, dopamine is both, i don't remember if its equal between MAO-B and MAO-A but its at least close.
MAO-B does some shit, I forget what. Fuck MAO-B, I think it mainly is just helpful because it helps with the Dopamine and some other shit but I totally forget what thats related to. Maybe PEA? I forget how to spell it, phenethylalamine? Maybe? I know it has something to do with mood, but I forget how significantly.
Now, MAOI's! The I stands for 'Inhibitor.' The idea is to stop MAO-A and/or MAO-B (lets say A and B for this) from fucking up all that serotonin and all the other nice neurotransmitters.
MAOI's can inhibit A or B equally, or some are designed to target one over the other.
A is a cool guy because now theres more serotonin and friends, but he also is kind of fucking us because he also breaks down this shit called Tyramine. Tyramine is in foods and stuff, like, a lot of fucking foods, and delicious ones too. When A isn't around so much, that tyramine builds up and then you fucking die. [don't do that]
B helps with dopamine but isn't even touching the tyramine, so if the medication only involves B, dietary problems are gone totally.
Now, generally, MAOI's are shitty, don't work as well as SSRI's, and have dangerous side effects.
I know it was a shitty explanation but I felt it need to be said.
You will die from shitty diet and drug intake.

 

[Mr Blonde]

^ Well, that was interesting.

For anyone not interested in reading that shit, the difference between MAO-A and MAO-B is this: MAO-A breaks down dopamine, serotonin, norepinephrine and norepinephrine. MAO-B breaks down dopamine and phenethylamine (and benzylamine). Breakdown of dopamine is usually split equally between these two MAOs, but this can vary from individual to individual.

There are selective MAOIs, but the MAOIs selective for B haven't found that much use in medicine yet. They have been used in depression and Parkinson's.

I won't go into the but about the dietary restrictions because that has already been mentioned. Man, what a post to copy for us to read. 8)

 

[Davevanza]

Hi,

Yeah...

I just have no idea why, even my Psychiatrist who has the Authority to prescribe Ritalin ( Methylphenidate) and Dexamphetamine, is reluctant.

He said that, ( well, it's his opinion) , they are very very dangerous medications when used as an augmentation to Antidepressants.

But I replied, that, in the States, most Psychiatrist even prescribe them ( Adderall-a mix of several different amphetamine salts form, Vyvansa- a pro drug that is converted into amphetamine in our bodies, Ritalin - even 9 yrs old child is taking it like candies up to 50mg, Concerta- a long acting form of Methylphenidate).


Too bad.

He said, man, this is Australia, not USA.

The only thing he is willing to prescribe is Parnate ( Tranylcypromine), which resembles like amphetamine.

Eldepryl ( Selegiline) in the States is used as an antidepressant under the name of Emsam.
I just have no idea about Psychiatrist here.


I tried RIMA ( Reversible Inhibitor of Monoamine-A), called Moclobemide.
When used within therapeutic range ( 600mg is the max) , it inhibits the oxidation of mainly Serotonin-Noradrenaline-Dopamine ( about 80%), and Phenylethylamine about 20%.

Eldepryl ( Selegiline) here is only prescribed for Parkinson's Disease.
It is a MAOI-B.
Mainly it inhibits the oxidation od Dopamine and Phenylethylamine.
Even though the half life is 2.5 hours, its effect ( as it is actually irreversible) lasts up to 3 -4 days.
And it has an active metabolite, Amphetamine, but, mainly only works peripherally, not on our CNS.
So, there is no feeling of " well-being-euphoria", in fact, making us feel more agitated, restless, etc.......

Well, has anyone been using Parnate? i just want to know the effect, as some people on the other forums said that, once they are on it, they feel motivated, euphoric, etc..( amphetamine-like effects)


Kind regards
Dave

 

[Davevanza]

Well, I guess not many people taking Parnate.

As I am still waiting for those who are on it.

 

[Mr Blonde]

^ I doubt there are many on it at all. This is only the second time I've heard of it, and though it is listed on the PBS, doctors these days are wary of prescribing irreversible MAOI's.

 

[Azron]

Have used will write more after me largy shuffle

 

[Azron]

The food restrictions really arn't that bad, It's more to avoid them not 'Never eat a banana again' for eg.(talk to your dr.) my major problem was the contraindication with stimulants I ended up using again(The reason I stopped Parnate).

I drank beer reasonably heavily whilst being treated with it but not recomended obviously.

I found that at first there was slight insomnia, but personally nothing to worry about as its effectiveness tired me through the day.

I found Nardil to be more stimulating in my experience but more insomnia and agitation/irratabilty type side effects.

I am a bit confused here.....What do you really want here? An anti-depressant or a stimulant?

Over all easily the most effective AD iv'e used to treat anxiety/depression. (Still a bit of a wank tho like newer AD's)

 

[Azron]

Foods to avoid

Avocados, Bananas, Figs, Raisins, and Sauerkraut

Beef or Chicken liver, Fish, Meats prepared with tenderizer, Bologna, Pepperoni, Salami, Summer sausage, Game meat, Meat extracts, Caviar, Dried fish, Herring, and Shrimp paste

Beer, Red wine (especially Chianti), Sherry, Vermouth, and other distilled spirits

Caffeine (including coffee, tea, coke) and

Cheeses, including American, blue, Boursault, Brick, Brie, Camembert, Cheddar, Emmenthaler, Gruyere, Mozzarella, Parmesan, Romano, Roquefort, Stilton, and Swiss

Chocolate

Ginseng

Sour cream and Yogurt

Soy sauce, Miso soup, Bean curd, Fava beans or yeast extracts.

Unless your a foreign cheese, chocolate and sausage fanatic, i found it easy to minimize the amounts of foods rich in Tyramine.

 

[Dunno]

Is this stuff any good for Anxiety, Panic attacks? How does it compare as a replacement for Alprazolam?

 

[Azron]

yes.. very good for anxiety and depression espesially both.... works on them main 3 n.transmaitters almost evenly. Did me well for anxiety.. Unused alot thesedays due to dietary restrictions which are potentially deadly, and these are non- reversible maoi's. Not for every one. I found sucess but then did i really as im still on high dose clonaz. Talk to dr. but unlikely to be rx'd but yeah im drunk... better than a xanax habbit but then what would i know... Talk to dr

 

[Davevanza]

Well i bring back the topic left 4yrs ago.
I ve gone thru many meds.

I got phobias, social anxieties.
my psych prescribes oxazepam .
I got nervous tension that my neurulogist gives me tramadol.
I got insomnia that is given mirtazapine.

Now.... the problem here in syd...even the 2 specialists are reluctant to add on with dexamphetamine/MPH even Modafinil or even vyvanse. I got severe lethargic ....struggle...like hell....tired....no motivation....everytime i wake up.
Thats the reason why i consider Parnate ( tranylcypromine)

No matter how i convince my specialists they wont prescribe amph/MPH etc....as an add on.

In usa i guess pdoc would willingly mix the meds which ease my anxiety....headache....but also add with meds that help with my tiredness...lethargy...hypersomnia ....everytime i get up from bed.

Any suggestion that anyone who happen 2be in sydney being prescribe with these meds?

(If no other way..the only thing is Parnate. But i see how it interact with tyramine?