AlsoTapered
Bluelighter
- Joined
- Apr 1, 2023
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Paradoxical Effects of N-Cyanoalkyl Substituents upon the Activities of Several Classes of Opioids
Publication Name: Journal of Medicinal Chemistry
Publication Date: 1979-07-10
PMID: 218015
DOI: 10.1002/chin.197928328
It would appear that while in some cases replacing the N-methyl with a 2-cyanoethyl can increase the analgesic activity of SOME classes of opioid by a factor of 57, it doesn't reverse abstinence syndrome in animals dependent on 'classical' opioids.
My guess is that it produces selective NOP ligands or NOP/DELTA. NOP ligands will eventually replace classical opioids because it isn't dependence forming but back when the paper was written, I don't think 3 subtypes had been identified, let alone NOP (ORL1).
It could be that it's really euphoric and people with no opioid dependence would love it, but it might have no effects apart from analgesia.
Surprised nobody has gone back to look into it.
Publication Name: Journal of Medicinal Chemistry
Publication Date: 1979-07-10
PMID: 218015
DOI: 10.1002/chin.197928328
It would appear that while in some cases replacing the N-methyl with a 2-cyanoethyl can increase the analgesic activity of SOME classes of opioid by a factor of 57, it doesn't reverse abstinence syndrome in animals dependent on 'classical' opioids.
My guess is that it produces selective NOP ligands or NOP/DELTA. NOP ligands will eventually replace classical opioids because it isn't dependence forming but back when the paper was written, I don't think 3 subtypes had been identified, let alone NOP (ORL1).
It could be that it's really euphoric and people with no opioid dependence would love it, but it might have no effects apart from analgesia.
Surprised nobody has gone back to look into it.