Back in my early days of taking psychedelic RCs, I would puke like 10+ times every time during the come-up of 2C-I, 2C-T-2, and 2C-E. So much nausea, head over the toilet while the world is exploding in fractals and the walls are breathing. Weirdly, over time I completely stopped getting even remotely nauseous from psychedelics, not even the slightest hint of it anymore, ever. It's been who even knows how many years since I puked from drugs, even alcohol. I used to puke a lot from alcohol though, when I was younger.