so under the for professionals information on modafinil it says
"PROVIGIL is readily absorbed after oral administration, with peak plasma concentrations occurring at 2-4 hours. The bioavailability of PROVIGIL tablets is approximately equal to that of an aqueous suspension. The absolute oral bioavailability was not determined due to the aqueous insolubility ( < 1 mg/mL) of modafinil, which precluded intravenous administration. Food has no effect on overall PROVIGIL bioavailability; however, time to reach peak concentration (tmax) may be delayed by approximately one hour if taken with food."
Is this a joke? How could they just say well its not dissolving so lets skip bioavailability for a fda approved drug?? And how do they know eating doesnt influence bioavailability of they never measured bioavailability just because the cmax is the same? So for all I know the bioavailability could be 1% and with or without food it doesnt matter because its basically zero. Or it could be like 100 percent.
"PROVIGIL is readily absorbed after oral administration, with peak plasma concentrations occurring at 2-4 hours. The bioavailability of PROVIGIL tablets is approximately equal to that of an aqueous suspension. The absolute oral bioavailability was not determined due to the aqueous insolubility ( < 1 mg/mL) of modafinil, which precluded intravenous administration. Food has no effect on overall PROVIGIL bioavailability; however, time to reach peak concentration (tmax) may be delayed by approximately one hour if taken with food."
Is this a joke? How could they just say well its not dissolving so lets skip bioavailability for a fda approved drug?? And how do they know eating doesnt influence bioavailability of they never measured bioavailability just because the cmax is the same? So for all I know the bioavailability could be 1% and with or without food it doesnt matter because its basically zero. Or it could be like 100 percent.
