How so ?
"Roads" goes on to state in 9b) Antagonism of the 5-HT2c serotonin receptor results in a disinhibition of that dopamine in the nucleus accumbens, ventral tegmental area and other parts of the mesolimbic and mesocorticol reward pathways. This leads Mirtazapine to produce more stimulant effects the higher the dosage used; especially after histamine receptors down regulate following a few weeks of daily administration. SWIM no longer takes his Remeron at night, but in the morning due to this exact reason. SWIM almost always gets a nice "head buzz" for a few hours after taking Remeron. The increased dopamine production/release in the reward pathways may help explain the mild euphoric properties; especially in high doses (90-120mg+).
Dopamine in the Nucleus Accumbens and the Ventral striatal zone serve to fulfill reward seeking and to prevent apathy, Abulia, Anergia, depression and anxiety. The Caudate acts as the Brains " Gear shifter" to the Orbito Pre-frontal cortex and then back to regulate/modulate through the Caudate > Putamen> Globus Pallidus and then to other areas of need. This is the Frontal Striatal circuit, which is largely innervated with Dopamine, originating from the Substantia Nigra proper.
9a) probably was copied or presented Incorrectly , as was most likely intended to read as " To Block RE-UPTAKE of Dopamnine and Norepinephrine" meaning there's a more steady and abundant supply.
See down further he states :
Furthermore, the aforementioned blockade of 5-HT2c serotonin receptors disinhibits dopamine in the most important cerebral parts to us SWIMmers: The Mesolimbic dopamine pathway. The pleasure center baby! SWIM theorizes that this disinhibition allows amphetamine to not only have access to more stores of dopamine, but to allow it to release more and at a higher rate when it does open those depots.
Disinhibits means does not Inhibit or Block!
101- Keep in mind his post is regarding his Hypothesis that adding Mirtazapine can potentiate his Stimulant Medication.