Methylphenidate - other esters?

[i are spectre]

well, ethyl phenidate isnt very hard to make, or come by, at least for now... ritalin will be around for a while... and there's always that H+ and Cl- hangin out in the ol stomach... there's the ritalinic acid already...

i mean, how many esters do people eat a day really. theyre freakin everywhere, you dont need BOOZE, but itd be easier... but ive had some ideas...

anyway, wouldnt propylphenidate or isopropylphenidate have perhaps a little bit longer half life? not sure how it binds... im more of the chem guy, basic a&p... this is all theory... feel free to pm... there are a lot of other... options...

i see ethylphenidate not being shipped to many countries, the list grows rapidly, and it is harder for transactions etc...

anywho, get in touch my thoughtful thinkers... for i love the ethyl ester which has made it all the way to 7:30am and still doing linear algebra...

what if that C went sp3 with two R groups... eh be a little more tough but not that hard... that little hydrogen is safe over there with Mr N on the left butt cheek... wow i need some sleep...

 

[ebola?]

We see a drop in potency moving from methylphenidate to ethylphenidate. Does SAR suggest such to follow further with larger alkyl substitutions?

ebola

 

[sekio]

I believe so, yeah... generally the ester group on cocaine cannot be futzed with too much. By the time you hit a phenyl group the compounds have lost a considerable amount of "fun".

I would like to see an oxazole analog of methylphenidate however

 

[i are spectre]

drop in potency? what are you measuring? from what i hear it stays away from NE a bit and helps dopamine stick around longer, compared to methylphenidate

but the acid is pumped in our stomach in a nutshell, HCl + ritalin gives us the acid, i have no idea the dissassociatiom constants or anything now, dont really have the time to be looking into this now, but winter break...

but some larger groups... wouldnt it hang out longer, as in, longer half life, not so much up down up down...

http://www.clinchem.org/content/56/4/585/F1.large.jpg

http://www.clinchem.org/content/56/4/585/F2.large.jpg

http://www.clinchem.org/content/56/4/585/F4.large.jpg

wasnt aware of this... im quite interested and im not doing my homework!

shit man RA concentrations are way up there compared to the methyl ester... man i cant stop lookign into this stuff

kinda tuff gettin them pdfs right now..

http://www.clinchem.org/content/56/4/585.full but i habvnt slept i gotta get back to my school work... ugh

a lot of hair and oral samples... but it would SEEM like youd want a high pH for more dopamine to stck around and a lower pH for the NE bang... ya

 

[Sprout]

Apologies for necro'ing but this seemed a good place to ask:

Anyone have any recent data on Isopropylphenidate (IPPD)?
It seems to have been studied very briefly without much in the way of actual data.

Should we expect a reduction in potency due to alkyl addition (a la MPD > EPD)?
Obviously, the HL should be extended, but would this render the compound less reinforcing than MPD, as seen in 3,4-CTMP?

 

[SteadyEddie]

http://www.ncbi.nlm.nih.gov/pubmed/24261661

 

[Sprout]

Thanks.
That article suggests pretty much what is expected: preferential DA:NE ratio and extended HL due to alkylation.

I should have this in my possession soon. Anyone see a problem with accurate weighing (lab scale used), and volumetric dosing in dH2O. After allergy tests (note the plural) and titration, a dose of 15-20mg orally should be active, right? Presuming it follows MPD --> EPD potency.