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  • BDD Moderators: Keif’ Richards | negrogesic

Stimulants Meth - interactions with anti-psychotics vs tolerance effects

Jabberwocky

Frumious Bandersnatch
Joined
Nov 3, 1999
Messages
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Although I’m trying to quit shooting meth I’ve been wondering about this because my very rapidly increasing use of meth coincided with being put on higher (20 mg) dose of Abilify.

When I first started (IV) I would receive a euphoric 6 hour high that usually involved high horniness and extreme mental alterness from a one point shot. I had little desire or need to redose quickly,

My pattern of usage was 24 hours on followed by 2-3 days break which I maintained for a few months with a one month break due to intermational travel. I would redose once in 24 hours at this time. Sometimes I would use seroquel to sleep and reduce comedown effects.

After about 3 months of this pattern I had ceased using seroquel and was taking Abilify and catapres every night and my shots had grown to 2+ points and I no longer experienced euphoria but still got super horny. I was also redosing every 4-6 hours and using a gram each time I used. Most importantly, the rush and cough were still there but it simply felt like a wave of heat across my body and brain. I felt ‘normal’ within an hour of a shot - usually less. At this point I was also able to sleep lightly 6 hours after my last shot. My comedowns were noticeably mild - low level depression and high level of laziness and just wanting to stay in bed for a day.

Meth remained enjoyable but only about 20 % as enjoyable as peak goodness when I first started. I wondered whether euphoria might still be there at a 3 point shot or higher but I was mostly too scared to go there so can’t say.

So even though everybody is unique my question here is whether the rapid loss of euphoria and the shortening of the time I was energised (methergised?) was more likely the meds which I began at the same time or just fast increase in tolerance?

Also this heat flush rush - is that common with either meds or with tolerance?

Finally, Is the sleepiness a sign of ‘over-amping’ in general and A sign I’d just had too much?

I neither want to quit my meds or save up my dopamine to have another shot in a month to test where the answer might be....I mainly want to stay off meth but am curious about how meds & tolerance interact.
 
What was the abilify prescribed for out of curiosity?
 
I no longer experienced euphoria but still got super horny.

Abilify's actions on (against) dopamine are more extensive than they are on norepinephrine, so i would guess this is why you may experience more prosexual effects than euphoric. Its antiserotonergic effects may play a role as well.

Not sure i read the question carefully enough but yes, aripiprazole will diminish the effects of methamphetamine, and in some ways more than others.
 
How bad is your bipolar? Maybe its hard to tell the effects of stims if your already manic.
 
I'm on an antipsychotic and mood stabilizer and used to use meth.

Not sure about the tolerance, but i did get a "heat rush", and never got psychotic.
 
Do you really want to use the meth or do you just end up taking the meth because you want to take meth and the mania makes you unable to inhibit your actions?

I think this is a subtle but big difference. I think its pretty significant that you only use it when manic.

For example, the difference between i like porn and want to watch it. So, i watch for like 20 minutes feel satisfied then move on because my rational brain knows if i just watch it all day that will cause issues in my life.

Vs.

I like porn. I want to watch porn. I feel manic. No matter how much porn i watch i never feel satisfied. Its like i cant pull the breaks and reign in my behavior.

Idk if that made sense. I just really am concerned maybe your meth use may be tied more to your manic episodes then what you want. And, possibly also why your never satisfied.

Im not bashing drug use it just seems suspicious to me you only want it while pretty manic.
 
Do you really want to use the meth or do you just end up taking the meth because you want to take meth and the mania makes you unable to inhibit your actions?

Idk if that made sense. I just really am concerned maybe your meth use may be tied more to your manic episodes then what you want. And, possibly also why your never satisfied.

Im not bashing drug use it just seems suspicious to me you only want it while pretty manic.

Thanks. I think you are largely correct. I actually don’t want to take drugs and especially don’t want to take meth. However, every few years when I have a major manic episode I find myself back on them. My last run with meth started just a few months after I stopped taking my bi-polar meds.

I’ve enjoyed drugs in the past and also had problems with them (always stims) but have other priorities in life at the moment that meth is beginning to impede quite a bit.

I suspect I need rehab that specialises in dual-diagnosis i.e drug addict + bi-polar (and ADHD). At the moment I’m focussed on staying off the meth long enough for my meds to take effect properly - one problem with meth is that it is caused by mania but thereafter becomes fuel for the mania
 
I dont have "bipolar" but i am on some meds used for bipolar lithium and depakote and i can see how easy it is to stop meds.

Like for me especially mood stabilizers like depakote and lithium i swallow them and absolutely nothing happens. Like im used to drugs i take them and something happens i associate the good feeling or awakeness then i use that to reason why im taking it. So, i often think to myself man these arent important why do the blood work, doctors, ect im fine....

Then thankfully i think wait thats right im not in a hospital or psych work since ive been on these because i havent been acting crazy. and almost every year up to the point of taking them i have ended up in a hospital or psych word. Soo i should prob take them

Maybe thats just me idk sorry im rambling
 
staying on subject — is there known interactions with cymbalta (fuck that shit. harder to detox off of than heroin)
 
Pretty sure your supposed to taper off with a doctor to make sure you dont get depressed or the discontination syndrome.

Also, im just giving you a heads up. Id be careful making statements like x drug is worse or harder than y drug. I dont think any rules are against it but it might get people upset or start a arguement. Again im not even a moderator and think its ok to say. But i just think you dont mean i that way and if i said something that could be misinterpreted id appreciate someone saying something.
 
I was on arapiprazole for a while, didn't have a chance to add n-methylamp to the mix: but I have mixed some SSRIs in large doses like fluoxetine, 80mg a day, and had major psychotic episodes. 500mg seratraline faired better but SamE, which works great for me, also gave psychosis as a result with n-methylamp. Which I concede gives psychosis well enough on its own. Considering all the things you could mix it with Arapiprazole diminishing it's effect has to be the furthest from a lead worry of contraindications there.
 
I just found this study that suggests Abilify actually potentiates meth and makes it more effective (though study used very low doses of meth). If that is true then my problem is just tolerance. However, if I understand it correctly, Abilify also increases desire for methamphetamine when combined with small doses. Several other earlier studies say the complete opposite though.

 
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