Is this a paradoxical feeling like people can sometimes get with narcotics, or making someone who took 200 mg of caffeine sulphate want to lay down and take nap?
Or rebound from the E, maybe enough is being taken to cause a mild abstinence syndrome like with slamming down dihydrocodeine cough syrup* with carisoprodol and tripelennamine every day for a three weeks or about 16 shots of Miss Emma or The Big D through an IV in hospital?
Or is this the neurotransmitter and receptor down-regulation and/or burnout from semi-regular, high dose use? That is the toughest nut to crack and appears to be part of the reason that a lot of E people feel rotten on Mondays and even worse on Tuesdays (or whatever their schedule allows.)
---
* Of course it could also be codeine, dionine (ethylmorphine) , peronine (benzylmorphine), hydrocodone, nicocodeine, nicodicodeine, hydromorphone, opium, tipepidine, methadone, levo-methadone, propoxyphene, levopropoxyphene, dimenoxadole , normethadone, thebacon, dipipanone, acedicon, thebacon, racemethorphan, benzhydrocodone, phenadoxone, noracymethadol, dihydromorphine , . . . or, back in the good old days, heroin (it even came in lozenges for both adults and kids) as well as acetylmorphone, dibenzoylmorphine, and acetylpropionylmorphine and other heroin analogues from the 1920s.