I've read where some believe and others don't about there being any differences in prescription meds. I can assure you that there is absolutely no question that exists that Mallinckrodt Methadone is substantially better than Roxanne. Also, when Sandoz was manufacturing Ritalin sr it worked a great deal better than any other Ritalin sr or er and also worked at least 2 hours longer. Just as well with Klonopin, the blue ones work much better than the green or yellow ones. Someone said there was no difference because the FDA required manufacturers to use the same " ingredients" or formula. Well that's not exactly true. The FDA requires manufacturers' formula to be 95% consistent and you can rest assured manufacturers take advantage of the 5% they have. Another thing is the FDA does not require whatsoever that manufacturers use the same bonding agents to hold their medicine together in the shape of a caplet, tablet, or disket. Therefore some of the bonding agents used by some manufacturers can actually dilute the potency of their medication but they do so anyway to help prevent and make it more difficult for those who crush their medicines for the purpose of sniffing it or shooting it. This is so it is much more difficult to grind it to a powder that can be comfortably sniffed or pass through a needle of a syringe. So in closing; there is a significant difference between a number of prescription medications.