TCMVegas
Bluelighter
- Joined
- Nov 22, 2012
- Messages
- 147
Compd[9]_ DAT (Ki) _DA (IC50)_ NET (Ki) _NE (IC50)
D-TMP ____161 _____23 _______206 ______39
L-TMP ____2250 ____1600 ______>10K ____980
DL-TMP ____121 _____20 _______51 ______788
How can the IC50 of DL-TMP (racemic methylphenidate) POSSIBLY be more than double that of D-TMP? This would imply that L-TMP lowers the efficacy of d-TMP, possibly by binding competitively to NET, and thus displacing d-TMP.
But that wouldn't make sense, due to the Ki values in the table showing that L-TMP has no affinity for NET.
Shouldn't racemic TMP be at least as half as potent on NET as d-TMP is, provided that l-TMP is not a competitive ligand?
D-TMP ____161 _____23 _______206 ______39
L-TMP ____2250 ____1600 ______>10K ____980
DL-TMP ____121 _____20 _______51 ______788
How can the IC50 of DL-TMP (racemic methylphenidate) POSSIBLY be more than double that of D-TMP? This would imply that L-TMP lowers the efficacy of d-TMP, possibly by binding competitively to NET, and thus displacing d-TMP.
But that wouldn't make sense, due to the Ki values in the table showing that L-TMP has no affinity for NET.
Shouldn't racemic TMP be at least as half as potent on NET as d-TMP is, provided that l-TMP is not a competitive ligand?
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