Foreigner
Bluelighter
- Joined
- Mar 18, 2009
- Messages
- 8,300
A friend of mine does LSD once a month as a migraine preventative. It's the only thing that works for her. No pharmaceuticals do the job. There used to be an ergotamine suppository on the market called Cafergot but it has since been discontinued and replaced with a myriad of drugs that don't work.
My observation is that migraines in general seem to be a product of some kind of over-sensitivity. The triggers that migraine sufferers have tend to be things that don't bother other people, but for them trigger instant migraine onset... such as cologne, tannins, sudden atmospheric pressure changes, etc.
I researched LSD and found that, along with ergotamine, it's a non-specific ergoloid that acts as an agonist on the entire 5ht system. Other pharmaceuticals target maybe one or two receptor sub-categories, but ergoloids just go for the whole shabang. Somehow this agonism downregulates the receptors from being overactive/oversensitive and thus prevents vasoconstriction and in turn migraines from being triggered.
I'm wondering if anyone here has more specific information aside from what I just wrote, since it could shed more light on this problem for me. My friend doesn't seem bothered that she has to do LSD regularly to treat this problem, but for someone like me, doing LSD that often would cause psychological problems. She insists that it has to be an hallucinogenic dose for it to work, and threshold doses don't cut it.
I would love to discover some kind of generalized 5ht agonist like the ergoloid family, but so far my research has turned up nothing. Maybe if I knew more about the mechanism of LSD I could do more investigating.
Thoughts on this?
My observation is that migraines in general seem to be a product of some kind of over-sensitivity. The triggers that migraine sufferers have tend to be things that don't bother other people, but for them trigger instant migraine onset... such as cologne, tannins, sudden atmospheric pressure changes, etc.
I researched LSD and found that, along with ergotamine, it's a non-specific ergoloid that acts as an agonist on the entire 5ht system. Other pharmaceuticals target maybe one or two receptor sub-categories, but ergoloids just go for the whole shabang. Somehow this agonism downregulates the receptors from being overactive/oversensitive and thus prevents vasoconstriction and in turn migraines from being triggered.
I'm wondering if anyone here has more specific information aside from what I just wrote, since it could shed more light on this problem for me. My friend doesn't seem bothered that she has to do LSD regularly to treat this problem, but for someone like me, doing LSD that often would cause psychological problems. She insists that it has to be an hallucinogenic dose for it to work, and threshold doses don't cut it.
I would love to discover some kind of generalized 5ht agonist like the ergoloid family, but so far my research has turned up nothing. Maybe if I knew more about the mechanism of LSD I could do more investigating.
Thoughts on this?