Is there cross tolerance between opiates and amphetamines?

[deadendgame]

My tolerance to amphetamines is sky high. I'm trying to turn that shit around and switch to opiates. Would that work?

 

[roi]

No cross tolerance, but vastly different effects.

 

[dopamimetic]

Don't do that. The price you'll have to pay for opiates is far higher & different ... if you're really interested in moderating your tolerance, look into the glutamate pathway and/or the new implications for tolerance ... NMDA antagonists can be a good thing as well as a magnesium supplement with good bioavailability like Mg glycinate, but there's evidence that even N-acetyl cysteine can help when taken rightly.

These things can help with opiate tolerance too, but at least in my eyes if you get to know and love the dissociatives (and stimulants to a lesser extent- when you take the rebound and after effects off the dopaminergics, they are a completely different experience and become much more nootropic-alike), you don't need these nasty opiates really- just let them for those with bad physical pain..