RCs Is there any safe way to use ODSMT while being on SSRIs?

[Anxiousanxious]

I'm already aware it's serotonin syndrome waiting to happen. Prozac 40. Was given I think at least a gram of ODSMT and the opiate euphoria is calling to me.

Answering my own question seems redundant but is the seizure/death risk really overplayed with tram/odesmethyltram? Or is it super legit and not worth touching at all. Thanks.

 

[falsifiedhypothesi]

You seem to already know the risk and i'm not judging but it seems you are just looking for permission from someone. I don't think anyone here is going to tell you this is a good idea. If you must get high please try to find a different opiate.

 

[Anxiousanxious]

Yeah you're absolutely correct. I don't buy opiates because of expense and high addictive potential but free is for me (only indulge after root canal, medical procedure etc). I was 'gifted' over a gram of something that I believe takes effects at 10-20mg (check before you dose) and I just feel like it's a shame for it to go to waste. It won't last forever , maybe vacuum sealed, but I will NEVER stop taking SSRIs after 20 years on them the withdrawals protracted lasted 16 or 18 months last time I tried to quit with proper taper and life became so unbearable I would have rather have died. Back on the SSRIs it was and I could live again.

word to any parents out there - don't let them bastard shrinks push head meds on your teenage children because of social anxiety. IF only we knew so much better back then, the consequences of these drugs now.

 

[thefirm]

give the gift back or trade them for some other opioid, if you don't want to throw them away, best case scenario you will only have a seizure, worst case scenario you will have a seizure AND SS

 

[Wilson Wilson]

Someone please do correct me if I'm wrong, but O-DSMT has no serotonin reuptake inhibitor effects and therefore should not cause an interaction with an SSRI, right?

Again please do tell me if I'm wrong, but according to Psychonaut Wiki for example:

The two enantiomers of O-DSMT show quite distinct pharmacological profiles; both (+) and (−)-O-DSMT are inactive as serotonin reuptake inhibitors, but (−)-O-DSMT retains activity as a norepinephrine reuptake inhibitor, and so the mix of both the parent compound and metabolites contributes significantly to the complex pharmacological profile of tramadol.

Another site, Drugs Classroom, similarly states:

Tramadol is easily classified as an SNRI because it has core actions of inhibiting serotonin and norepinephrine. This is mostly absent with O-DSMT. Bamigrade (1997) reported R,R-Tramadol significantly blocked serotonin uptake at 5 μM in vitro, while S,S-Tramadol and O-DSMT had no significant impact. Another in vitro study looking at noradrenergic activity showed tramadol significantly increased extracellular norepinephrine levels by 25% at 1 μM, while even at 10 μM O-DSMT only had a weak facilitatory effect of 17% (Driessen, 1993). Given how drastic the potency difference is between opioid activity and monoamine reuptake inhibition activity for O-DSMT, it effectively loses the SNRI characteristic of tramadol.

OP is on fluoxetine which is an SSRI not an SNRI, so there shouldn't be an interaction between the NRI effects of O-DSMT and his medication.

It is well known that NRI opioids carry much much less seizure risk than SNRI opioids - see tramadol vs. tapentadol for instance.

Is there a vital detail I'm missing here that makes this combo more dangerous than I think it is?

OP don't take my comment alone as advice, others are warning against it so strongly so I may well be missing something here, I'm asking people for information as the data I can see suggests O-DSMT should have no effect on serotonin, yet I'm still seeing warnings that it's risky to combo with SSRIs, so I am confused.

 

[Anxiousanxious]

This is the reason for me posting this thread, Wilson. I studied the same results but I don't want to risk guinea pig results. I'm also benzo dependent so this will be future use if ever, I am taking an insane amount of benzos. Please disregard that last statement in terms of original discussion but as always, never mix opiates and benzos.

 

[Phonetap]

Following what has been said above i also think that there wouldn't be a risk of serotonin syndrome like with tramadol due to the absence of SNRI activity

 

[Kelmasterflex]

I'm testing tramadol and 40 mg fluoxetine now

 

[Shall9000]

How does a person get opiates really ? I have a friend who’s just been diagnosed with rheumatoid arthritis, compressed discs in spine, lupus & Sjögren’s syndrome. It took many years. They just made an apt for a pain specialist but can’t get in for about a month. Arizona has the strictest laws on opiates it’s ridiculous. Any doctor is afraid to prescribe them anymore. They don’t know where to go & it’s driving her nuts. They don’t know where to buy them.