In my knowledge ethanol is best known as GABA agonist and NMDA antagonist. After tried several substances with more pronounced NMDA antagonism (ketamine, nitrous, MXE) as GABA agonism, I noticed on low doses they create physical sensation of drunkenness with almost no alteration in cognitive function (body is drunk, mind is sober). GABAergic substances, such as benzodiazepines, do not create pronounced physical effects on me, only a little mental relaxation. Does it mean that feeling "drunk" is the mixture of NMDA antagonism and GABA agonism, or there is action on other receptors also important?
In other words, can this feeling (or extremely similar) be caused only by combining the action of pure NMDA antagonism and GABA agonism?
In other words, can this feeling (or extremely similar) be caused only by combining the action of pure NMDA antagonism and GABA agonism?