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  • BDD Moderators: Keif’ Richards | negrogesic

Is the "drunk" feeling the combination of NMDA antagonism and GABA agonism?

Renald

Bluelighter
Joined
Jul 8, 2015
Messages
222
In my knowledge ethanol is best known as GABA agonist and NMDA antagonist. After tried several substances with more pronounced NMDA antagonism (ketamine, nitrous, MXE) as GABA agonism, I noticed on low doses they create physical sensation of drunkenness with almost no alteration in cognitive function (body is drunk, mind is sober). GABAergic substances, such as benzodiazepines, do not create pronounced physical effects on me, only a little mental relaxation. Does it mean that feeling "drunk" is the mixture of NMDA antagonism and GABA agonism, or there is action on other receptors also important?
In other words, can this feeling (or extremely similar) be caused only by combining the action of pure NMDA antagonism and GABA agonism?
 
Alcohol is kind of a shotgun drug, even opoids play a big role in subjective effects, especially rewarding effects. Idk how much a role the NMDA antagonism is playing in the subjective effects but I know NMDA receptors are playing a role in withdrawal.
 
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