Hey there. So I have some 4mg Hydromorphone pills. I have read that the oral bioavailability of the medication is very low. Since this is the case, how many MG would be to much? When I take Oxycodone I take about 40mg and when it comes to Hydrocodone I have taken up to 70mg. Per a few sources anything over 10mg is a heavy dose of Hydromorphone. Yesterday I took 12mg but it was on a full stomach and spaced out over an hour. Does anyone know what a safe dose would be for this stuff? I read its mostly used IV and that is not something I plan to do. Any advise on a safe oral dose to get some effects?