Well, 10 of them is 3,250mg of acetaminophen (325 x 10), so doing this once in a while will be fine. However it's healthier (even if only doing it once in a while but certainly very important if doing it regularly) to do a cold water extraction on the pills. To do that, crush them all up and put them in a glass of cold water, and stir for a good 5 minutes. Then let it rest for 10-15 minutes. You will notice at the bottom of the glass is a bunch of white powder. That is the acetaminophen, it is not water soluble. however the hydrocodone is, and will be in the water. You can proceed to drink the water and leave the powder on the bottom. You can use a coffee filter to get all the hydrocodone water and none of the acetaminophen powder.