Misc How Many Deaths From Acetaminophen Are There A Year, Really?

[Xorkoth]

Yeah I agree ibuprofen is also unsafe to take daily.

 

[Ne0]

Too much ibuprofen causes kidney failure and too much acetaminophen causes liver failure, nice combination.

 

[ChemicallyEnhanced]

No one in their right mind should be taken that much ibuprofen you think that if you take acetaminophen and ibuprofen in large amounts that it’s not as dangerous as opiates but it is. So tired of doctors thinking that is the answer when it just causes more trouble

Acetaminophen and NSAIDs are both way more damaging than opioids. As long as you don't OD or run out you can take them indefinitely without really doing any harm.

 

[SpunkySkunk347]

newsflash, Ibuprofen is terrible for the liver as well, but someone with only those first two pieces of information might think they are "safe" as long as they don't experience stomach upset etc.

Not like acetaminophen is.
A main metabolite of acetaminophen is toxic to liver tissue on contact. Any amount of acetaminophen damages the liver.

The liver does have enough enzymes for a few grams of acetaminophen to metabolize it and its toxic metabolite, but after about 3-5 grams this enzyme becomes increasingly occupied in a sense, and the liver 'runs out' of it and has to begin making more.

Anything above 4 grams is causing a more substantial level of damage to the liver.

4 grams a day will kill the liver eventually.

6 grams every day will kill the liver a little more rapidly (a year and a half or so).

8 grams a day will kill the liver in less than a year, even just a few months, and can be a lethal single dose

8 grams at once can be lethal, and is approximately where the bell curve for lethal dose becomes apparent

10 grams a day will kill the liver in just a few months, and even from a single use (now substantially on the bell curve for Lethal Dose)

12 grams is well up on the bell curve for Lethal Dose

14 grams is on the other side of the bell curve for Lethal Dose (14 grams will kill most people who take it)

20 grams at once is almost certain death

These numbers are pretty much what most people have stated the dangerous/lethal doses to be over the years, and staying below them has kept many of us alive.

You SHOULD be doing a Cold Water Extraction if you're going to take large amounts of opioids paired with acetaminophen.

Remember, any large single dose of acetaminophen causes long term damage to the liver (4 grams or more, like someone with a tolerance who takes nine 5 mg hydrocodone 500mg acetaminophen pills to get high, which is 4500mg of acetaminophen).

It takes years, even decades, for the liver to recover from the damage that large doses of acetaminophen do to it, If The Liver Can Even Recover At All

Remember, 4 grams a day is different from 4 grams at once.
Taking 4 grams at once every day will kill the liver a LOT sooner than 4 grams taken over the course of each day.

 

[blythe5050]

Acetaminophen and NSAIDs are both way more damaging than opioids. As long as you don't OD or run out you can take them indefinitely without really doing any harm.

Thank u