Benzos How do benzo's (particularly Diazepam) and Antipsychotics Interact?

[ChemicallyEnhanced]

Would my chlorpromaine (low dose, 50mg a few times a day) or Quetiapine (the occasional 25mg) negate or take away from the enjoyment of the Valium or would it have a potentiating effect like other sedative (alcohol, opioids..)?

 

[Survived Abortion]

Chlorpromazine is a pretty powerful first-generation anti-psychotic, and it will completely swallow the effect of the diazepam. Not that you won’t feel the combined effect of both, but the chlorpromazine will overwhelm it. I would expect seroquel to act similarly.

Maybe the diazepam will somewhat reduce the akathisia from the anti-psychotic and make it slightly less anhedonic. But I wouldn’t risk a benzo addiction for that purpose.

To be fair, both Thorazine and Seroquel should be sedating/anxiolytics enough on their own. Depending on indication, I would suggest only one or the other, as both at the same time is probably unnecessary.

 

[ChemicallyEnhanced]

Chlorpromazine is a pretty powerful first-generation anti-psychotic, and it will completely swallow the effect of the diazepam. Not that you won’t feel the combined effect of both, but the chlorpromazine will overwhelm it. I would expect seroquel to act similarly.

Maybe the diazepam will somewhat reduce the akathisia from the anti-psychotic and make it slightly less anhedonic. But I wouldn’t risk a benzo addiction for that purpose.

To be fair, both Thorazine and Seroquel should be sedating/anxiolytics enough on their own. Depending on indication, I would suggest only one or the other, as both at the same time is probably unnecessary.

I wasn't gonna take benzos FOR that reason. I'm prescribed the antipsychotics and sometimes I take them, sometimes I don't/
I just recently started using Valium again for unrelated reasons.