Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,082
despite the conflicting scientific reports, many people swear by High quality HGH as a miracle fat burner superior to anything else they’ve ever tried. biologically, this makes sense as GH directly stimulates lipolysis as well as increasing fat tissue sensitivity to the lipolytic affects of catecholamines. it simultaneously decreases fatty acid reuptake into adipose tissue whilst conversely increasing fatty acid uptake in muscle, where they are more likely to be burnt rather than stored. however, I feel that GH induced insulin resistance may be a unique, important and very beneficial component of the fat loss equation that sets it apart from all other known fat burners. as you probably already know, insulin is the most powerful fat storage hormone and some research suggests High levels of insulin are needed to maintain body fat mass in the obese state. interestingly, The mechanism of insulin resistance produced by GH is poorly understood, but is thought to be explained by a combination of enhanced peripheral fatty acid uptake/oxidation at the expense of glucose, upstream inhibition of AKT and thus inhibition of insulin stimulated glucose uptake via upregulation of P85Alpha in muscle and fat tissue and both direct and indirect inhibition of pyruvate dehydrogenase via PDK4 and Direct binding respectively. this is where things get interesting. GH induced insulin resistance doesn’t only lead to enhanced lipolysis but also to a glucose conserving affect as the bodies muscles are encouraged to use fat as the preferred fuel. This is important when dieting because long-term hypoglycaemia, even when harmless or beneficial produces symptoms of weakness, low mood/energy, agitation and strong cravings/hunger. personally, I believe low blood sugar is The biggest cause of Weight loss diet failure for most people. with this in mind, taking GH when in a calorie deficit may directly promote fat loss through lipolysis and fatty acid oxidation by muscle, but also indirectly by maintaining blood glucose levels, thus keeping energy levels, Mood and satiety in the optimum range. we mustn’t forget, GH is actually a counterregulatory hormone, Whose function was to protect against starvation induced hypoglycaemia by fighting against the actions of insulin while simultaneously preserving lean body mass.
Because of the many unwanted side-effects of GH supplementation, certain peptide fragments of the GH molecule have been developed, with the most well-known being the IOD series if I remember correctly. proponents boast about The strong lipolytic effects of these peptides, but also about the lack of mitogenic and insulin antagonistic effects. removing the mitogenic effect makes absolute sense as it’s linked to the most serious GH side-effects, including bone overgrowth and damage. nevertheless, the biggest marketing point for these peptides seems to be that they don’t interfere with glucose metabolism or that they may even help lower blood glucose levels. for the above-mentioned reasons, you can see why I don’t like these peptides as the loss of the anti-insulin effect is in my opinion, the loss of a huge portion of the fat fighting affect. listening to a few YouTube videos and Reading online reviews seem to back up my theory. not with direct evidence, but those I’ve listened to suggest The peptide fragments aren’t particularly effective and of those that are, they don’t come close to real full length GH. this is interesting, because some of these peptides are actually more stable than the GH molecule itself and one analog can even be ingested orally.
I understand why people fear high glucose levels, but in most cases, this fear is unjustified. GH induced insulin resistance is rapidly reversible and elevated blood glucose is only harmful in the long-term.
Please let me know what you think.
Because of the many unwanted side-effects of GH supplementation, certain peptide fragments of the GH molecule have been developed, with the most well-known being the IOD series if I remember correctly. proponents boast about The strong lipolytic effects of these peptides, but also about the lack of mitogenic and insulin antagonistic effects. removing the mitogenic effect makes absolute sense as it’s linked to the most serious GH side-effects, including bone overgrowth and damage. nevertheless, the biggest marketing point for these peptides seems to be that they don’t interfere with glucose metabolism or that they may even help lower blood glucose levels. for the above-mentioned reasons, you can see why I don’t like these peptides as the loss of the anti-insulin effect is in my opinion, the loss of a huge portion of the fat fighting affect. listening to a few YouTube videos and Reading online reviews seem to back up my theory. not with direct evidence, but those I’ve listened to suggest The peptide fragments aren’t particularly effective and of those that are, they don’t come close to real full length GH. this is interesting, because some of these peptides are actually more stable than the GH molecule itself and one analog can even be ingested orally.
I understand why people fear high glucose levels, but in most cases, this fear is unjustified. GH induced insulin resistance is rapidly reversible and elevated blood glucose is only harmful in the long-term.
Please let me know what you think.
