You kinda misread my question there. Its that 'would using larger amounts, less often, as shots, be the longer iasting tool for avoidance of withdrawal, or would taking periodic little nibbles using a pipe? For a given quantity of gear.
On the one hand it's easier
to make adjustments, when smoking and it doesn't commit the gear like a shot, once a shot is prepped, drawn up, and the needle inserted into a vein, it's going
to be injected, not like I'm going to change my mind and a/b it to get one prepped shot back to smoke after is it?.
I don't take methadone on a detox basis, I'm scripted morphine and oxy. And, while I've none of the oxy, I do have most of a half 8th of good gear, that hasn't seen too many pairs of hands left, after buying an 8th yesterday (and an actual 8th, weight on, not some shitty excuse from an average dealer with his dick up his nostrils and spunk dribbling out of his ears from the inside of his skull.)
And don't give me no bollocks about how it isn't harm reduction.
For one, it is-opioid withdrawal is harmful. Ergo, avoiding it, is reducing harm by preventing occurance of that harmful event. If you do not believe it to be harm, then will you voluntarily permit me to, after forcing on you, fentanyl (in clinical doses, of a medical grade, known concentration), sufficient to keep you unconscious bar intermediate rousals for the purpose of intake of food and fluid, and to make trips to the toilet to remove waste.
And after six months, to inject you with a 500mg dose of naltrexone every six hours?
I didn't think so, somehow. And if I did do this, involuntarily, you would certainly consider yourself to have been harmed, wouldn't you not?
(this is to be taken entirely as a thought-exercise, and not in the very tinest bit, as a threat, or indeed actual suggestion that this be done; only to be spoken of, and considered of course)
And B: I'm not facing withdrawal, not as such. If I don't take opioids I will alright, that is for sure, the question is, how to make the 250mg of methadone, total, and the H I have, last the longest, when the purpose is not to get shitfaced high, that, I could manage on my own good self without too much difficulty, I do so believe
But to spin it out, and avoid withdrawal, feel fine, without getting high, using whatever ROA for the gear is most advantageous to further the purpose of doing so, for as long as possible. I.e, which ROA as suggested, will permit this to be done longest?
Given the posts that are looked on as being just fine on BL, don't single me out. There are plenty posts on BL about ROAs, plenty that have fuck all to do with harm reduction WHATSOEVER, such as 'should I take the acid first, or the MDMA first for the best candyflip' or 'how often do you change the brillo pad in your crack pipe', all manner of psychedelic, entactogen, weed, steroid, etc. etc. etc. etc. posts which have as much to do with HR as I have to do with helping the pope shag 10-year-old choirboys after he gets so geriatric and palsied he can barely lift his favourite crucifix-shaped papal noncing dildo.
My post has a lot more to do with HR than does many posts which are considered just fine here.
As for krokodil....EWWW!! jesus christ. I wouldn't fucking dream of making krokodil. Thats just nasty!
Desomorphine on the other hand, is different, and does not have the whole flesh rotting 'make sure you either burn them or destroy the brain!' factor to it, it's just another, albeit reportedly extremely euphoric, and highly potent opioid (not too potent however, 1mg desomorphine-D is apparently equal to 10mg morphine if both are used IV, although desomorphine is shorter acting)
Krokodil is the nasty russian slop that results from a Nagai reduction being used, along with no proper cleanup of the resulting shite, AFAIK after use of SOCl2 to chlorinate codeine and make alpha-chlorocodide. Then this is, to the best of my knowledge, subjected to the Nagai, and the product used once the reduction has been performed; without proper cleanup.
Even WITH proper cleaning, the Nagai reduction is just too damn harsh for use on phenanthrene opioids (it's the same process as used to make meth from pseudoephedrine or ephedrine, red phosphorus and iodine), Sure, I have a couple of kg of red phosphorus hanging around, and plenty I2, but you don't bloody think I'm going to use the damn Nagai reduction like the russians do to make the same sort of disgusting, flesh-necrotizing rusty coathanger abortion of a clusterfuck excuse for a dirty helping of sewage that might, just might, have a bit of desomorphine in there, do you? Fucking hell.
Alpha-chloromorphide, rather than the chlorocodide will bee the intermediate, and pharmaceutical morphine the starting material, once rigorously cleaned of all the sulfate ion (SO4- is a known catalyst poison for precious metal hydrogenation catalysts), and after the chloromorphide is in hand, catalytic hydrogenation employing Pd/C will be the route, or perhaps palladium black. One cannot in this, substitute platinum, BTW, as it's too active a catalytic metal and will lead to a tetrahydrodesomorphine product instead. Doubtful as to whether it is toxic, but also, probably not particularly active.
Alpha-chloromorphide, I have experience with, BTW. Quite a peculiar drug. I never got to reduce it the first time, as I ended up exploring it's bioactivity in it's own right, as there were no reports of this having been done. Morphine was chlorinated using thionyl chloride, in anhydrous acetone as the solvent for each, the SOCl2 being added dropwise to an acetone solution of morphine sulfate cooled in an ice-salt-methanol-ethylene glycol bath using a suspension of sodium carbonate as a base to scrub the formed SO2 and HCl.
After workup, it was then tested, once the PH had been adjusted, melting points taken and what have you, until fit for in-vivo use.
Turned out to be a peculiar psychostimulant. Odd in that it was devoid of peripheral sympathomimetic type effects or anything noradrenergic feeling centrally, nothing whatsoever like an amphetamine or mixed DA/NE reuptake inhibitor such as methylphenidate or triple reuptake inhibitor like cocaine.
Rather, it was a curious enlivening of the mental processes, with colour enhancement visually, a sparkle to it although not in a way suggesting it may have in common, any activity with serotonergic psychedelics. And it didn't relieve opioid withdrawal either, it mildly ameliorated morphine/oxy WD when tested to see if it would substitute for conventional opioids. It did not. At any dose tested (I forget the doses now, I no longer have the notes, after a HD failure unfortunately). Dose was the limiting factor in it's exploration, because at the highest doses tested, clonus of the extremities began to occur. And I am in little doubt that in excess, an overdose of the drug would prove to be a convulsant. Below such levels however, it was a most interesting substance to explore.
Unfortunately, the studies in-vivo, that time, used up all the alpha-chloromorphide I had. So, I'm saving some more morphine up, and going to have another shot at it. NOT, I repeat NOT krokodil, but desoxymorphine-D,
