Interesting article.
For me, there is no doubt in my mind that the consumption of mind altering substances - whether they typically induce feelings of euphoria (e.g. Cocaine, Alcohol) or not (SSRIs, Neuroleptics) - can also physically alter the human brain in the long term.
Obviously that's probably not a good thing, yet, what if it is in certain cases? More specifically, what if these alterations may be beneficial to someone who - as an example - is suffering from PTSD due to a traumatic childhood in which he was physically and sexually abused?
The aforementioned possibility of long term benefits from the consumption of certain psychotropic substances should warrant further studies and research of certain 'street drugs' such as MDMA, Ketamine, Psilocybin, THC, and so forth, because I strongly believe that the brain of an adult who grew up experiencing physical and/or emotional trauma (including - again - physical and sexual abuse) has most likely developed abnormally when compared to a child who was never the victim of such inexcusably disgusting treatment.
Although I have no objective evidence to support my suspicions, I believe in the possibility that, an adult's brain which has experienced severe physical and emotion trauma as a child ends up continuously releasing abnormally high amounts of stress hormones such as Cortisol and Epinephrine - as if his brain considers it normal - compared to a 'normal' adult brain which would not react in such a manner given similar circumstances. And as a result, such an individual is probably far more prone to experiencing long term or chronic symptoms of anxiety and/or depression (and possibly a lot worse), and may end up desperately trying to self-medicate in order to be free - even if it's only temporary - from his own sober, lucid state of mind which has been conditioned with a persistent over-the-top flight-or-fight response, but I digress.