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medfedd

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Jul 19, 2010
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So two years ago I got hit by a car and had a severe closed head trauma, and ever since i've had about 6 or 7 more mild concussions, and I have rolled a few times before and not had a problem, but I ate multiple pills at Global the other day and ever since i've noticed quite a few personality changes and lack of motivation/apathy and a severe headache that kinda follows me around. Now, I dont have health insurance, so i'm just kinda posting around the web asken people opinions as to whether or not i may get back to "normal" at some point. Links to literature is appreciated.
 
So you ate a shit ton of pills at a rave and now you are paying the consequenses.

Nothing in your post sounds out of the odinary to me.
 
Matt's right. Global was only a week ago (if you're referring to the party at redrocks) and it sounds like you're simply having (typical) hangover symptoms. I hope you get to feeling better!! :D
 
well I ate 2, one double stack then a single half way threw, didn't dance all night and stayed hydrated, didn't roll all that hard, but now i've been having adverse effects kinda following me around, I was more asking if anyone knew of any research done with TBI (traumatic brain injury) and PCS (post concussive syndrome) with MDMA ingestion. Yeah i realize a little too late, but still curious.
 
I bet that kind of info is extremely har to find if not nonexistant. that condition is pretty obsure and it would be tough to find a large enough sample population who had the same condition and took MDMA to get any meaningfull data from.

from your last post it sounds like you didn't test the pills and don't know for sure that what you took was MDMA. First, you say "double stack" which means nothing. second taking 3 quality MDMA pills would have most people rolling hard unless your tolerance is ungodly high. I would bet you just over did it or got some sort of cocktail pill causing worse after effects
 
Lol, with multiple pills I was thinking like 15 or something. That dose sounds pretty reasonable, and so it is a little weird to be feeling after effects a week later, but I wouldn't panic just yet.

And sorry don't have any of the information you are looking for mate. I'm curious though, how did you manage to get 7 concussions in 2 years?
 
The news on this doesn't look too friendly...

http://www.physorg.com/news115566047.html

Club drugs inflict damage similar to traumatic brain injury
November 29, 2007

What do suffering a traumatic brain injury and using club drugs have in common? University of Florida researchers say both may trigger a similar chemical chain reaction in the brain, leading to cell death, memory loss and potentially irreversible brain damage.

A series of studies at UF over the past five years has shown using the popular club drug Ecstasy, also called MDMA, and other forms of methamphetamine lead to the same type of brain changes, cell loss and protein fluctuations in the brain that occur after a person endures a sharp blow to the head, according to findings a UF researcher presented at a Society for Neuroscience conference held in San Diego this month.

“Using methamphetamine is like inflicting a traumatic brain injury on yourself,” said Firas Kobeissy, a postdoctoral associate in the College of Medicine department of psychiatry. “We found that a lot of brain cells are being injured by these drugs. That’s alarming to society now. People don’t seem to take club drugs as seriously as drugs such as heroin or cocaine.”

Working with UF researchers Dr. Mark Gold, chief of the division of addiction medicine at UF’s McKnight Brain Institute and one of the country’s leading experts on addiction medicine, and Kevin Wang, director of the UF Center for Neuroproteomics and Biomarkers Research, Kobeissy compared what happened in the brains of rats given large doses of methamphetamine with what happened to those that had suffered a traumatic brain injury.

The group’s research has already shown how traumatic brain injury affects brain cells in rats. They found similar damage in the rats exposed to methamphetamine. In the brain, club drugs set off a chain of events that injures brain cells. The drugs seem to damage certain proteins in the brain, which causes protein levels to fluctuate. When proteins are damaged, brain cells could die. In addition, as some proteins change under the influence of methamphetamine, they also begin to cause inflammation in the brain, which can be deadly, Kobeissy said.

Kobeissy and other researchers in Gold’s lab are using novel protein analysis methods to understand how drug abuse alters the brain. Looking specifically at proteins in the rat cortex, UF researchers discovered that about 12 percent of the proteins in this region of the brain showed the same kinds of changes after either methamphetamine use or traumatic brain injury. There are about 30,000 proteins in the brain so such a significant parallel indicates that a similar mechanism is at work after both traumatic brain injury and methamphetamine abuse, Kobeissy said.

“Sometimes people go to the clubs and take three tablets of Ecstasy or speed,” Kobeissy said. “That may be a toxic dose for them. Toxic effects can be seen for methamphetamine, Ecstasy and traumatic injury in different areas of the brain.”

About 1.3 million people over the age of 12 reported using methamphetamine in the previous month, according to the 2006 National Survey on Drug Use and Health. In 2004, more than 12 million Americans reported having tried the drug, the survey’s findings show.

People often think the effects of drugs of abuse wear off in the body the same way common medications do, but that may not be the case, Gold said.

“These data and the previous four years of data suggest some drugs, especially methamphetamine, cause changes that are not readily reversible,” Gold said. “Future research is necessary for us to determine when or if methamphetamine-related brain changes reverse themselves.”

Gold and Dennis Steindler, director of UF’s McKnight Brain Institute and an expert on stem cells, are planning studies to find out if stem cells can be applied to repair drug-related brain damage.

UF researchers are also trying to uncover all the various ways drugs damage and kill brain cells. During their protein analysis, researchers discovered that oxidation was damaging some proteins, throwing the molecules chemically off balance.

“When proteins are oxidized they are not functional,” Kobeissy said. “When proteins are not working, the cell cannot function.”

Neurologist Dr. Jean Lud Cadet, chief of the molecular neuropsychiatry branch of the National Institute on Drug Abuse, said analyzing proteins is important to understanding how drugs such as methamphetamine affect the brain.

“I think saying the results of methamphetamine abuse are comparable to the results of a traumatic brain injury is a new idea,” Cadet said. “I agree with (the findings). Our own work shows that methamphetamine is pretty toxic to the brains of animals. In humans, imaging studies of patients who use methamphetamine chronically show abnormalities in the brain.

“Abuse of methamphetamine is very dangerous.”

Source: University of Florida
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Yikes, that doesn't sound too friendly. As for how I keep bangen my head around, I'm not quite certain how I keep managing to hit my head but I have quite the knack for it. In a 3 month period I had 3 concussions, one of which left me with 12 staples and 8 stitches in my head. From what I've read around the net there isn't much of a treatment for PCS, and I was feeling quite healthy when I went to global so decided to see how it went, but now I'm just having a tough time grounding my head again, quite still spaced. Guess all there is to do is take it easy from now on.
 
And yeah I had no idea what was in the pills, I had heard it was just MDMA pressed with caffeine, but I didn't get em tested so I cant be certain
 
medfedd said:
Yikes, that doesn't sound too friendly. As for how I keep bangen my head around, I'm not quite certain how I keep managing to hit my head but I have quite the knack for it. In a 3 month period I had 3 concussions, one of which left me with 12 staples and 8 stitches in my head. From what I've read around the net there isn't much of a treatment for PCS, and I was feeling quite healthy when I went to global so decided to see how it went, but now I'm just having a tough time grounding my head again, quite still spaced. Guess all there is to do is take it easy from now on.
Click to expand...

Fuck. The reason I asked was just because I wanted to make sure you actually remember getting injuries, you haven't been blacking out and potentially having seizures or anything like that?
 
naw, nothing like that...I blacked out last time I hit my head a few weeks ago, but other then that been pretty normal...just super spaced, memories a bit spotty.
 
I'm definitely not a health care professional, but my *guess* is that this is most likely not something permanant, and will probably go away within the next couple weeks. Some people will get depressed for a few weeks after rolling, esp. a heavy amount. I HIGHLY highly highly doubt it is anything permanant, so I would try not to worry too much although I'm sure that is much easier said than done.

I would probably be very, very careful rolling after your accident though, because you just never know if it could be possibly effected. I would recommend not taking very high doses anymore, for anybody that isn't a good idea, but esp. sine you have had a severe head injury and after experiencing this. Personally with e, I find less is usually more. I don't find that taking a shit ton of it really gets me any higher necessarily, but it does enhance the side effects,that's for sure. Be careful and I hope you start feeling better soon!! :)
 
Hey guys I've been lookin across the net to see if it would be a bad idea to roll after a light concussion last week plzzzz anyone? ?
 
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