Bupe Half Life differences between IV / Sublingual? 3 hours to 24-37? Am I detoxing myself?

[CantTrustEM]

So for the past week I've been IVing 4-8 mg of suboxone a day, instead of my typical either intranasal or sublingual routes.

I just looked up the half life for IV bupe and I found it to be 3-4 hours. the past week I have ONLY iv'd my suboxone,

So what I'm getting at is... am I wasting my suboxone by shooting because of such the drastic half life difference?

Is it actually worth saving my amounts and sublingual use over shooting it for benefit of lower doses lasting longer in my body?

This morning I shot a 4 mg piece, and now I almost feel sick and it almost makes sense why now... does any of this make sense to you people ?

 

[Nagelfar]

How do you shoot it without becoming sick immediately?

 

[CantTrustEM]

How do you shoot it without becoming sick immediately?

I don't have any full agonists in my system ... ?

That's a myth that naloxone is active when IV, at least for bupe's sake. It does nothing to me IVing it.

 

[catbird]

Why do you think the half life is different when iv’d?

 

[CantTrustEM]

Why do you think the half life is different when iv’d?

" The terminal half-life ranges from three hours after intravenous administration to 28 to 37 hours after sublingual administration.10 It is unclear why there is such a difference in half life depending on the route of administration but this may be related to sequestring of buprenorphine in the oral mucosa. Most of the buprenorphine is eliminated in the feces, with approximately 10 to 30 percent excreted in urine.11 "

because it says so in medical studies

Buprenorphine: A (Relatively) New Treatment For Opioid Dependence

Opioid dependence is a significant and growing problem in the United States. For nearly a century, federal regulations have made it illegal for psychiatrists and other physicians to pharmacologically manage this condition in an office-based setting using ...

www.ncbi.nlm.nih.gov

 

[CantTrustEM]

Bump.. can anyone confirm what I'm saying please?

 

[I_Hate_This_Place]

Bump.. can anyone confirm what I'm saying please?

No I can't confirm what you're saying... As though I have plenty of experience with IV & bupeprenorphine as well I have never had the urge to combine the 2. However; I can add that though the study you linked is relatively dated I haven't seen any studies that contradict it's findings in regards to the question you're asking.

From what I could find right off (I'm limited by paywalls & such) in the literature; anything I could find either supports the study you linked or does not address it in a meaningful way. Based solely on the literature I would be inclined to agree with what you quoted. If I throw in anecdotal experience I'm even more inclined to agree. As I've known people that would IV bupeprenorphine & like you they had similar issues. I know that's not the confirmation you where looking for but I do hope that this input is at least mildly helpful.