Although I've been doing a little research, I didn't get very far.
In the past, low potency benzodiazepines were more commonly prescribed.
What I get, is that in general low potency benzodiazepines are more sedating. The 'high potency' benzodiazepines are sort of a 'second generation' of benzodiazepines ?
What would be the mechanism of this different effect ?
I do have that impression that it has something to do with binding with a certain (selective) affinity for GABAA subunits, something I discussed in another thread. I haven't been able to get much information about that subject.
In the past, low potency benzodiazepines were more commonly prescribed.
What I get, is that in general low potency benzodiazepines are more sedating. The 'high potency' benzodiazepines are sort of a 'second generation' of benzodiazepines ?
What would be the mechanism of this different effect ?
I do have that impression that it has something to do with binding with a certain (selective) affinity for GABAA subunits, something I discussed in another thread. I haven't been able to get much information about that subject.