These drugs represent an odd class without precedent- in metabolism these will not be removed besides through NIH shift or epoxidation but even then the harm that presents is because of its ease to undergo these transformations (free radical species)
No commonly smoked drugs have fluoride atoms in them and if we consider conventional smoking of a form of plant matter and drug to be essentially vaporization and pyrolysis, simultaneously, then these compounds may be highly redox active in human lung cytochromes. At higher pyrolysis temperatures oxidation drives the force forming many species, look at a fire sometime..
They present a class capable of damaging lung systems but will not show any clinical results for a while, the lungs are very dense and damage must take time to accrue. Overall smoking these blends may be worse but will not show any effects, probably ever, except for populations smoking multiple times daily. Vaping at the correct temp is probably fine, but the intrinsic activity of these when smoked may be a problem but will not show any results.
Tldr
Don't be afraid of fluorine unless you pyrolysize these compounds by smoking them, multiple times daily. Even then effects might not show for months, the lung cytochrome systems are peculiar, clinical presentation probably asthma, bronchitis induced by particles, normal things..
Bottom line I don't know but these may undergo epoxidation in lung cyps by pyrolysis and damage lung tissue overlong time.
Zzedz
