I had a similar question, but my situation is a little harder to predict because even though it has been >6 months since using DXM it has only been a couple weeks since I've done MXE (and my tolerance got quite high over a 5 day binge).
As I understand it dissociative cross tolerance is not a complete crossover so even with a moderate MXE tolerance, I'm thinking 300mg should be enough for some decent antidepressant action. Not looking for a hard trip, just first or second plateau.