Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,083
Prescribed endothelin antagonists it would be interesting to hear your experiences particularly if you have combined them with opioids Endothelin antagonists are drugs used to control high blood pressure and they work by blocking the effect of the peptide endothelin at various receptor sites. Apart from being located in blood vessels endothelin receptors are expressed in high concentration in neurons throughout the brain, showing that endothelin peptide likely has a role as some sort of neurotransmitter or Neuromodulator. Such neurotransmission is very likely to be excitatory as injection of Endothelin directly into the brain of rats induced severe neurotoxicity and seizures often resulting in death, or severe memory impairment in survivors. Endothelin antagonists have been shown to be Neuroprotective under many circumstances including physical brain injury or exposure to exogenous and endogenous neurotoxins.
Another fascinating fact I have Red is that endothelin antagonists strongly reverse opioid tolerance without acting on the opioid receptor, rather they work by re joining G proteins which have been on coupled from the opioid receptor during tolerance development.
In animal tests endothelin antagonists reduced tolerance in animals fully dependent on morphine back to control levels. I really hope this applies to humans too.
Endothelin antagonists are also thought to have anxiety reducing and antidepressant effects as well as a possible antipsychotic effect that does not rely on dopaminergic signalling blockade.
Have any of you been Prescribed endothelin antagonists it would be interesting to hear your experiences particularly if you have combined them with
Another fascinating fact I have Red is that endothelin antagonists strongly reverse opioid tolerance without acting on the opioid receptor, rather they work by re joining G proteins which have been on coupled from the opioid receptor during tolerance development.
In animal tests endothelin antagonists reduced tolerance in animals fully dependent on morphine back to control levels. I really hope this applies to humans too.
Endothelin antagonists are also thought to have anxiety reducing and antidepressant effects as well as a possible antipsychotic effect that does not rely on dopaminergic signalling blockade.
Have any of you been Prescribed endothelin antagonists it would be interesting to hear your experiences particularly if you have combined them with