Nagelfar
Bluelight Crew
- Joined
- Nov 23, 2007
- Messages
- 2,527
It appears, from what I've seen of the literature, that there isn't the narcan equivalent of endorphins found to exist as made by the body (endorcans?).
Any papers with titles like "endogenous opioid antagonism" regard exogenous ligand antagonism of endogenous opioids.
Now I am well aware subjective experiences, cited as to what mechanism is truly taking place with regard to their own neurotransmitters, is the bane of subforums such as ours here. Scientifically unsound to say the least.
However as I am basing my following accordingly, I have little other recourse than the familiarity in these shared experiences: I myself have had information hit me, feelings of shame, more than simple embarrassment; those immediate moments of being told off or shot down, where a chill goes down my spine, I get cold and feel nauseated, in fact get goosebumps. A hot flush comes over me; very similar to many experiences being resuscitated with naloxone (once five times repeatedly in a single overdose scenario), post acute withdrawal, precipitated withdrawal especially. These are exaggerated when I have been in such a state and have felt any of the above.
Am I alone in presuming there is some manner wherein opioid receptors are naturally antagonized (inverse agonists to be more precise), is there any reason as to why not? Is there a specific scaffold of the G-coupled protein site, for mu particularly, which allows for inverse agonism that might then rightly be called an orphan receptor sub-complex of some kind, by that rationale?
I'm honestly perplexed as to why I cannot find more attempts at discovering such compounds in the body, are so many reactions, subjective feelings, explained away by other neuro-transmitters that interest has not been piqued to search for and isolate such a potential natural mechanism?
Any papers with titles like "endogenous opioid antagonism" regard exogenous ligand antagonism of endogenous opioids.
Now I am well aware subjective experiences, cited as to what mechanism is truly taking place with regard to their own neurotransmitters, is the bane of subforums such as ours here. Scientifically unsound to say the least.
However as I am basing my following accordingly, I have little other recourse than the familiarity in these shared experiences: I myself have had information hit me, feelings of shame, more than simple embarrassment; those immediate moments of being told off or shot down, where a chill goes down my spine, I get cold and feel nauseated, in fact get goosebumps. A hot flush comes over me; very similar to many experiences being resuscitated with naloxone (once five times repeatedly in a single overdose scenario), post acute withdrawal, precipitated withdrawal especially. These are exaggerated when I have been in such a state and have felt any of the above.
Am I alone in presuming there is some manner wherein opioid receptors are naturally antagonized (inverse agonists to be more precise), is there any reason as to why not? Is there a specific scaffold of the G-coupled protein site, for mu particularly, which allows for inverse agonism that might then rightly be called an orphan receptor sub-complex of some kind, by that rationale?
I'm honestly perplexed as to why I cannot find more attempts at discovering such compounds in the body, are so many reactions, subjective feelings, explained away by other neuro-transmitters that interest has not been piqued to search for and isolate such a potential natural mechanism?
