dopamimetic
Bluelighter
- Joined
- Mar 21, 2013
- Messages
- 2,070
I just can't and can't leave these dissociatives behind. Only their psychotic nature is a hefty contrast to that spark of life that they manage to ignite each and every time again when I have been captivated by depression ...
Maybe it is completely wrong but somehow the thought concept of a certain part of their (now speaking mostly about the 2'-OxO-PCx ones) side effects being due to a dis-synchronization between the CNS and the PNS. How I come to think that has to do with some weirder effects I observed when (ab)using named chemicals over longer amounts of time chronically.. a strong influence to the skin (pale and very dry, antihyperhidrotic), pinpoint pupils, stomach and intestines in general (sure identificators for PNS agents, aren't they?) and the interference of NMDA antags with opioids- there are some other weird PNS links about morphine dependence ...
Then all the dissociatives appear to be anticholinergics too. Even memantine is an antagonist of some nAChR's. Nicotine has a reaally weird effects relationship with dissociatives, it's mentioned even in that good old DXM FAQ by White..
DXM is a very strange one. I would bet abusing it led to long-lasting changes in some cholinergic circuits ... and after buprenorphine finally messed it up (could barely urinate on <1mg of bupe) I did not tolerate even therapeutic dosages of DXM again.
It was like a sequence with several (maybe 7-10) steps, together with the sense of a spring that gets squeezed and at some point switches back with an enormous burden for - umm, whatever. Think this is hard enough for you to follow as I'm not a native English speaker but also unlikely that others will get the same imagination for such things.
And as these symptoms got worse together with psychotic ones, well I thought about the connection but it's easier to get your hands on anticholinergics than on pro-cholinergics. The only one I know of is galantamine, and some weird russian pharms (Tacrine, Ipidacrine). My doctors didn't give a shit on that theorism when I sat there and could barely speak a word while having a clear mind (weird residual effect of some batches or at least one that has been stronger with some. But even then I thought it might have that in common, e.g. synth leftover with similar structure but being x100 on some peripheric choline enzyme)
Is it complete bullshit or not?
Maybe it is completely wrong but somehow the thought concept of a certain part of their (now speaking mostly about the 2'-OxO-PCx ones) side effects being due to a dis-synchronization between the CNS and the PNS. How I come to think that has to do with some weirder effects I observed when (ab)using named chemicals over longer amounts of time chronically.. a strong influence to the skin (pale and very dry, antihyperhidrotic), pinpoint pupils, stomach and intestines in general (sure identificators for PNS agents, aren't they?) and the interference of NMDA antags with opioids- there are some other weird PNS links about morphine dependence ...
Then all the dissociatives appear to be anticholinergics too. Even memantine is an antagonist of some nAChR's. Nicotine has a reaally weird effects relationship with dissociatives, it's mentioned even in that good old DXM FAQ by White..
DXM is a very strange one. I would bet abusing it led to long-lasting changes in some cholinergic circuits ... and after buprenorphine finally messed it up (could barely urinate on <1mg of bupe) I did not tolerate even therapeutic dosages of DXM again.
It was like a sequence with several (maybe 7-10) steps, together with the sense of a spring that gets squeezed and at some point switches back with an enormous burden for - umm, whatever. Think this is hard enough for you to follow as I'm not a native English speaker but also unlikely that others will get the same imagination for such things.
And as these symptoms got worse together with psychotic ones, well I thought about the connection but it's easier to get your hands on anticholinergics than on pro-cholinergics. The only one I know of is galantamine, and some weird russian pharms (Tacrine, Ipidacrine). My doctors didn't give a shit on that theorism when I sat there and could barely speak a word while having a clear mind (weird residual effect of some batches or at least one that has been stronger with some. But even then I thought it might have that in common, e.g. synth leftover with similar structure but being x100 on some peripheric choline enzyme)
Is it complete bullshit or not?